Exploring post-rehabilitation plasticity with intra-cerebral recordings on anomic profiles

Auteurs

Trébuchon A, Fasola A, Sabadell V, Dubarry AS, Carron R, Bartolomei F, Alario FX

Les auteurs en lien sont membres de l'INS.

Équipes

D-CAP, NeuroStim, DynaMap

Résumé

Background Patients with drug-resistant epilepsy involving the language network often exhibit anomic profiles in daily life due to difficulties with lexical selection processes. Very little evidence is available regarding the effects of language rehabilitation in this population. Objective(s) We aim to induce brain plasticity combined with improvements in behavioral performance using language therapy in patients with epilepsy. Methods We implemented a therapy focused on phonological and semantic features of infrequent words over three treatment sessions, each targeting a specific semantic category. Intracranial signals were recorded in 10 patients during baseline and post-therapy picture-naming sessions. Response times and the percentages of correct responses during naming tests were collected. Time-frequency analyses were conducted on intracranial signals, and comparisons were made between baseline and post-therapy conditions for each patient. Results Half of the patients demonstrated improved naming skills following the treatment. We observed significantly different recruitment of frontotemporal areas in the left hemisphere (including Broca's area) post-therapy in patients that i

Background Patients with drug-resistant epilepsy involving the language network often exhibit anomic profiles in daily life due to difficulties with lexical selection processes. Very little evidence is available regarding the effects of language rehabilitation in this population. Objective(s) We aim to induce brain plasticity combined with improvements in behavioral performance using language therapy in patients with epilepsy. Methods We implemented a therapy focused on phonological and semantic features of infrequent words over three treatment sessions, each targeting a specific semantic category. Intracranial signals were recorded in 10 patients during baseline and post-therapy picture-naming sessions. Response times and the percentages of correct responses during naming tests were collected. Time-frequency analyses were conducted on intracranial signals, and comparisons were made between baseline and post-therapy conditions for each patient. Results Half of the patients demonstrated improved naming skills following the treatment. We observed significantly different recruitment of frontotemporal areas in the left hemisphere (including Broca’s area) post-therapy in patients that i

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