Potential of ⁴ He OPM‐MEG for detecting interictal epileptic activity: A comparison with SQUID‐MEG

Auteurs

Schwartz D, Badier JM, Gutteling TP, Daligault S, Labyt E, Bonini F, Jung J

Les auteurs en lien sont membres de l'INS.

Équipes

DynaMap

Résumé

Abstract Objectives Conventional magnetoencephalography (MEG) based on superconducting quantum interference devices sensors (SQUIDs) is the only widely used MEG system in both clinical and research settings. However, it has limitations that hinder its widespread deployment. Optically pumped magnetometers (OPMs) offer several advantages over SQUIDs, particularly for epilepsy studies: lightweight and flexible, OPMs can be integrated into adaptable motion‐tolerant headsets, enabling recordings during seizures or natural head movements, and potentially enhancing the detection of interictal epileptiform discharges (IEDs). In the present study, we assess the capabilities of a 5‐sensor MEG system with helium OPMs ( 4 He‐OPMs) in detecting IEDs. Methods First, we compare the performance of SQUID‐MEG and 4 He‐OPM‐MEG in a group of 7 patients. Second, we perform combined intra‐cerebral (SEEG) 4 He‐OPM‐MEG and SQUID‐MEG recordings in a single patient to demonstrate the ability of both systems to detect IEDs originating from deep brain structures. Results The key finding is that both the SQUID‐MEG and the 4 He‐OPM‐MEG prototype, with a very limited number of sensors, successfully captured inte

Abstract Objectives Conventional magnetoencephalography (MEG) based on superconducting quantum interference devices sensors (SQUIDs) is the only widely used MEG system in both clinical and research settings. However, it has limitations that hinder its widespread deployment. Optically pumped magnetometers (OPMs) offer several advantages over SQUIDs, particularly for epilepsy studies: lightweight and flexible, OPMs can be integrated into adaptable motion‐tolerant headsets, enabling recordings during seizures or natural head movements, and potentially enhancing the detection of interictal epileptiform discharges (IEDs). In the present study, we assess the capabilities of a 5‐sensor MEG system with helium OPMs ( 4 He‐OPMs) in detecting IEDs. Methods First, we compare the performance of SQUID‐MEG and 4 He‐OPM‐MEG in a group of 7 patients. Second, we perform combined intra‐cerebral (SEEG) 4 He‐OPM‐MEG and SQUID‐MEG recordings in a single patient to demonstrate the ability of both systems to detect IEDs originating from deep brain structures. Results The key finding is that both the SQUID‐MEG and the 4 He‐OPM‐MEG prototype, with a very limited number of sensors, successfully captured inte

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