Scalp‐negative medial temporal interictal epileptic discharges alter large‐scale brain networks: A simultaneous high‐density <scp>electroencephalographic</scp> and intracranial <scp>electroencephalographic</scp> study

Auteurs

Roehri N, De Stefano P, Spinelli L, Marquis R, Lagarde S, Momjian S, Seeck M, Vulliemoz S

Les auteurs en lien sont membres de l'INS.

Équipes

DynaMap

Résumé

Abstract Objective Interictal epileptiform discharges (IEDs) observed on scalp electroencephalography (EEG) serve as a diagnostic hallmark of epilepsy. However, only a small fraction of IEDs recorded by intracranial EEG (iEEG) are detectable on the scalp; the vast majority remain invisible on scalp recordings. Nevertheless, epilepsy is associated with important brain network alterations and cognitive symptoms between seizures. Our study aims to investigate the impact of these scalp‐negative IEDs on the whole‐brain network, particularly those produced in medial temporal regions, given their consistent involvement across patients, their potential implications in cognitive deficit, and their relevance in both epilepsy and Alzheimer disease. To achieve this, we leveraged simultaneous iEEG and high‐density EEG (hdEEG) recordings. Methods We analyzed IEDs occurring solely in the medial temporal regions, not visible on the scalp, in nine patients with drug‐resistant epilepsy during simultaneous iEEG‐hdEEG recordings. These scalp‐negative IEDs were compared to epochs without any epileptic activity recorded in either modality. Spectral and network characteristics were investigated at the re

Abstract Objective Interictal epileptiform discharges (IEDs) observed on scalp electroencephalography (EEG) serve as a diagnostic hallmark of epilepsy. However, only a small fraction of IEDs recorded by intracranial EEG (iEEG) are detectable on the scalp; the vast majority remain invisible on scalp recordings. Nevertheless, epilepsy is associated with important brain network alterations and cognitive symptoms between seizures. Our study aims to investigate the impact of these scalp‐negative IEDs on the whole‐brain network, particularly those produced in medial temporal regions, given their consistent involvement across patients, their potential implications in cognitive deficit, and their relevance in both epilepsy and Alzheimer disease. To achieve this, we leveraged simultaneous iEEG and high‐density EEG (hdEEG) recordings. Methods We analyzed IEDs occurring solely in the medial temporal regions, not visible on the scalp, in nine patients with drug‐resistant epilepsy during simultaneous iEEG‐hdEEG recordings. These scalp‐negative IEDs were compared to epochs without any epileptic activity recorded in either modality. Spectral and network characteristics were investigated at the re

Lire l’article