Enhancing atypical Alzheimer's disease phenotyping through the oculomotor window in posterior cortical atrophy

Auteurs

Koric L, Mourre H, Trompette C, Brillant L, Favre M, Trinquet L, Ceccaldi M, Felician O

Les auteurs en lien sont membres de l'INS.

Équipes

D-CAP

Résumé

Background Although Alzheimer's disease (AD) is biologically well characterized, early and precise phenotypic diagnosis remains challenging, especially for atypical variants. Posterior cortical atrophy (PCA) is a rare form of AD with progressive neurovisual impairment related to degeneration in visual processing areas. Objective To investigate how alterations in eye movement metrics, measured through video-oculography (VOG), reflect dysfunction across distinct brain networks in various AD phenotypes, with particular emphasis on PCA. Methods This study compared oculomotor parameters derived from VOG saccade analysis in early AD patients exhibiting two clinical phenotypes, PCA-AD (n = 21) and amnestic mild cognitive impairment (aMCI-AD, n = 11), along with 27 age-matched controls. Parameters analyzed included saccade latency, gain, velocity, intrusions and antisaccade error rates. All patients exhibited cerebrospinal fluid biomarkers consistent with AD pathology. Results As expected, neuropsychological testing revealed more severe neurovisual and executive deficits in PCA-AD versus aMCI-AD, and greater memory storage impairment in aMCI. Oculomotor data showed that PCA-AD patients exh

Background Although Alzheimer’s disease (AD) is biologically well characterized, early and precise phenotypic diagnosis remains challenging, especially for atypical variants. Posterior cortical atrophy (PCA) is a rare form of AD with progressive neurovisual impairment related to degeneration in visual processing areas. Objective To investigate how alterations in eye movement metrics, measured through video-oculography (VOG), reflect dysfunction across distinct brain networks in various AD phenotypes, with particular emphasis on PCA. Methods This study compared oculomotor parameters derived from VOG saccade analysis in early AD patients exhibiting two clinical phenotypes, PCA-AD (n = 21) and amnestic mild cognitive impairment (aMCI-AD, n = 11), along with 27 age-matched controls. Parameters analyzed included saccade latency, gain, velocity, intrusions and antisaccade error rates. All patients exhibited cerebrospinal fluid biomarkers consistent with AD pathology. Results As expected, neuropsychological testing revealed more severe neurovisual and executive deficits in PCA-AD versus aMCI-AD, and greater memory storage impairment in aMCI. Oculomotor data showed that PCA-AD patients exh

Lire l’article