The burden of the postictal state in epilepsy: A prospective, single‐center observational cohort study

Auteurs

Les auteurs en lien sont membres de l'INS.

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Résumé

Abstract Objective The postictal state is a major yet underrecognized component of the epilepsy burden. We aimed to develop a structured patient‐reported instrument to quantify postictal recovery, characterize its multidimensional burden, and identify demographic, clinical, psychiatric, and treatment‐related factors associated with postictal severity and duration. Methods We conducted a prospective, single‐center observational cohort study (Timone Hospital, Marseille, February 2025–March 2026). Consecutive patients aged ≥15 years admitted for scalp or stereo‐EEG video‐monitoring were included. Patients completed the Postictal Recovery Scale (PRS), an 11‐domain questionnaire assessing fatigue, mood, sensory, motor, language, orientation, time perception, and postictal amnesia. Items were rated from 0 (severe impairment) to 3 (no symptoms), yielding a total score of 0–33. Internal consistency was assessed using Cronbach's alpha. Associations between PRS scores, subjective postictal duration and covariates were analyzed using group comparisons, correlations, and regression models. Results Of 107 enrolled patients, 96 were included. PRS showed good internal consistency (Cronbach's α =

Abstract Objective The postictal state is a major yet underrecognized component of the epilepsy burden. We aimed to develop a structured patient‐reported instrument to quantify postictal recovery, characterize its multidimensional burden, and identify demographic, clinical, psychiatric, and treatment‐related factors associated with postictal severity and duration. Methods We conducted a prospective, single‐center observational cohort study (Timone Hospital, Marseille, February 2025–March 2026). Consecutive patients aged ≥15 years admitted for scalp or stereo‐EEG video‐monitoring were included. Patients completed the Postictal Recovery Scale (PRS), an 11‐domain questionnaire assessing fatigue, mood, sensory, motor, language, orientation, time perception, and postictal amnesia. Items were rated from 0 (severe impairment) to 3 (no symptoms), yielding a total score of 0–33. Internal consistency was assessed using Cronbach’s alpha. Associations between PRS scores, subjective postictal duration and covariates were analyzed using group comparisons, correlations, and regression models. Results Of 107 enrolled patients, 96 were included. PRS showed good internal consistency (Cronbach’s α =

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