Hippocampal Seizure‐Related Burden is Associated with Accelerated Long‐Term Forgetting in Focal Epilepsy

Auteurs

Bratu IF, Lambert I, Felician O, Villalon SM, Trébuchon A, Bartolomei F

Les auteurs en lien sont membres de l'INS.

Équipes

D-CAP, DynaMap

Résumé

Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified. This study introduces cumulative hippocampal seizure‐related burden metrics and examines their association with long‐term memory consolidation. Methods A total of 20 consecutive patients undergoing stereo‐electroencephalography in Marseille (2016–2018) were prospectively included. Continuous stereo‐electroencephalogram recordings between 2 memory assessments (30 minutes and 1 week postencoding) were analyzed. Hippocampal ictal involvement and durations were assessed using epileptogenicity markers and visual stereo‐electroencephalogram analysis. The postictal period was quantified using permutation entropy. Cumulative hippocampal seizure‐related burden metrics (ictal, postictal, and combined) were computed across hippocampus‐involving ictal events. Verbal and visual memory were assessed using standardized recall and recognition tasks. One‐week performance was defined as the percentage score obtained at the 1‐week assessm

Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified. This study introduces cumulative hippocampal seizure‐related burden metrics and examines their association with long‐term memory consolidation. Methods A total of 20 consecutive patients undergoing stereo‐electroencephalography in Marseille (2016–2018) were prospectively included. Continuous stereo‐electroencephalogram recordings between 2 memory assessments (30 minutes and 1 week postencoding) were analyzed. Hippocampal ictal involvement and durations were assessed using epileptogenicity markers and visual stereo‐electroencephalogram analysis. The postictal period was quantified using permutation entropy. Cumulative hippocampal seizure‐related burden metrics (ictal, postictal, and combined) were computed across hippocampus‐involving ictal events. Verbal and visual memory were assessed using standardized recall and recognition tasks. One‐week performance was defined as the percentage score obtained at the 1‐week assessm

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