Modulation of neural complexity and consciousness in temporal lobe seizures: Effects of high‐frequency pulvinar stimulation

Auteurs

Bratu IF, El Youssef N, Lagarde S, Bartolomei F

Les auteurs en lien sont membres de l'INS.

Équipes

DynaMap

Résumé

Abstract Background Loss of consciousness/awareness during temporal lobe seizures significantly affects quality of life and is closely linked to pathological thalamocortical synchronization and loss of cortical signal complexity. The medial pulvinar nucleus (PUM) contributes to seizure propagation and awareness impairment, making it a potential target for neuromodulation. Acute high‐frequency PUM stimulation has previously been shown to reduce seizure severity and improve awareness, potentially by disrupting excessive synchrony. Aims In this study, we investigated the effects of PUM stimulation on signal complexity and its relationship to ictal awareness using permutation entropy (PE) in SEEG recordings. Materials and methods Eight patients with focal drug‐resistant temporal epilepsy underwent hippocampus‐induced seizures with and without additional high‐frequency PUM stimulation. SEEG complexity changes were quantified using PE and ictal awareness was assessed using the Consciousness Seizure Scale (CSS). Results Our results showed that PUM stimulation attenuated entropy reductions during seizures, suggesting a preservation of neural complexity. Moreover, reduced entropy alteration

Abstract Background Loss of consciousness/awareness during temporal lobe seizures significantly affects quality of life and is closely linked to pathological thalamocortical synchronization and loss of cortical signal complexity. The medial pulvinar nucleus (PUM) contributes to seizure propagation and awareness impairment, making it a potential target for neuromodulation. Acute high‐frequency PUM stimulation has previously been shown to reduce seizure severity and improve awareness, potentially by disrupting excessive synchrony. Aims In this study, we investigated the effects of PUM stimulation on signal complexity and its relationship to ictal awareness using permutation entropy (PE) in SEEG recordings. Materials and methods Eight patients with focal drug‐resistant temporal epilepsy underwent hippocampus‐induced seizures with and without additional high‐frequency PUM stimulation. SEEG complexity changes were quantified using PE and ictal awareness was assessed using the Consciousness Seizure Scale (CSS). Results Our results showed that PUM stimulation attenuated entropy reductions during seizures, suggesting a preservation of neural complexity. Moreover, reduced entropy alteration

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