Mapping Postictal Aphasia through Signal Complexity: A Stereo‐Electroencephalography Study

Auteurs

Bratu IF, Bénar CG, Villalon SM, Ciavatti L, Mazel F, Bartolomei F, Trébuchon A

Les auteurs en lien sont membres de l'INS.

Équipes

DynaMap, D-CAP

Résumé

Objective The postictal period provides an opportunity to investigate the pathophysiology underlying aphasia and recovery following epileptic seizures. This study examines postictal aphasia in stereo‐electroencephalography (SEEG)‐explored patients to identify brain regions associated with task‐specific language deficits using signal complexity analysis. Methods We evaluated video‐SEEG‐recorded focal seizures with and without postictal aphasia in patients with SEEG‐confirmed hemispheric language dominance. SEEG traces were analyzed using permutation entropy (PE), with the postictal period quantified by a PE‐based metric, the Postictal Alteration Time (PAT). Brain region PAT was correlated with language function recovery (eg, repetition). Electro‐clinical recuperation was also assessed within the dorsal‐ventral language stream framework. Additionally, a bedside testing battery was developed to evaluate postictal aphasia severity and task‐specific deficits. Results A total of 322 seizures from 98 patients were analyzed. Seizures with postictal aphasia had longer PAT than those without. Task‐specific language recovery correlated with regional PAT (eg, naming – middle temporal gyrus). M

Objective The postictal period provides an opportunity to investigate the pathophysiology underlying aphasia and recovery following epileptic seizures. This study examines postictal aphasia in stereo‐electroencephalography (SEEG)‐explored patients to identify brain regions associated with task‐specific language deficits using signal complexity analysis. Methods We evaluated video‐SEEG‐recorded focal seizures with and without postictal aphasia in patients with SEEG‐confirmed hemispheric language dominance. SEEG traces were analyzed using permutation entropy (PE), with the postictal period quantified by a PE‐based metric, the Postictal Alteration Time (PAT). Brain region PAT was correlated with language function recovery (eg, repetition). Electro‐clinical recuperation was also assessed within the dorsal‐ventral language stream framework. Additionally, a bedside testing battery was developed to evaluate postictal aphasia severity and task‐specific deficits. Results A total of 322 seizures from 98 patients were analyzed. Seizures with postictal aphasia had longer PAT than those without. Task‐specific language recovery correlated with regional PAT (eg, naming – middle temporal gyrus). M

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