Magnetoencephalography biomarkers for assessing myelin content and neuronal function in acute optic neuritis

Auteurs

Beigneux Y, Gitton C, Anwar AR, Lemarechal JD, Hamzaoui M, Paques M, Vignal C, Audo I, Bodini B, Stankoff B, Leocani L, Lubetzki C, George N, Louapre C

Les auteurs en lien sont membres de l'INS.

Équipes

TNG

Résumé

Abstract The visual pathway is an important model system for remyelination and neuroprotection trials in multiple sclerosis, due to its accessibility and the availability of validated methods including visual evoked potential and optical coherence tomography. However, visual evoked potentials are sometimes undetectable and demonstrate limited reliability after acute optic neuritis. This study aims to investigate novel magnetoencephalography markers for assessing myelin content and neuronal dysfunction in the early phase of optic neuritis and describes their inter-run reproducibility (‘over a single visit’) and association with short-term visual outcomes. Patients with unilateral acute optic neuritis were recruited and underwent ophthalmological assessments, brain MRI and magnetoencephalography. Magnetoencephalography data were acquired during visual stimulation with an alternating checkerboard pattern. We used source localization to reconstruct brain activity in the primary visual cortex (V1) and analysed it in the temporal and frequency domains. In the temporal domain, we focused on M100 latency—the magnetic counterpart of P100 latency. In the frequency domain, we assessed the spe

Abstract The visual pathway is an important model system for remyelination and neuroprotection trials in multiple sclerosis, due to its accessibility and the availability of validated methods including visual evoked potential and optical coherence tomography. However, visual evoked potentials are sometimes undetectable and demonstrate limited reliability after acute optic neuritis. This study aims to investigate novel magnetoencephalography markers for assessing myelin content and neuronal dysfunction in the early phase of optic neuritis and describes their inter-run reproducibility (‘over a single visit’) and association with short-term visual outcomes. Patients with unilateral acute optic neuritis were recruited and underwent ophthalmological assessments, brain MRI and magnetoencephalography. Magnetoencephalography data were acquired during visual stimulation with an alternating checkerboard pattern. We used source localization to reconstruct brain activity in the primary visual cortex (V1) and analysed it in the temporal and frequency domains. In the temporal domain, we focused on M100 latency—the magnetic counterpart of P100 latency. In the frequency domain, we assessed the spe

Lire l’article