A review of epileptic markers: from ion channels, astrocytes, synaptic imbalance to whole brain network dynamics

Auteurs

Banerjee S, Jirsa V

Les auteurs en lien sont membres de l'INS.

Équipes

TNG

Résumé

Epilepsy, a neurological disorder characterized by recurrent seizures, presents a complex interplay of cellular and molecular mechanisms. The symptoms manifest themselves at various scales, from ion channels to brain regions to behavior in humans. Various screening, treatment, and preventive measures use this knowledge to tackle the disorder effectively. This article aims to summarize the current state of the art in epileptic markers from ion channels, astrocytes, and synaptic imbalance to whole brain Network Dynamics. Recent research has shed light on the critical involvement of astrocytes, the multifunctional glial cells, in the pathogenesis and modulation of epileptic seizures in humans. Astrocytes, once considered as mere supportive cells, are now recognized as active participants in the regulation of neuronal excitability, synaptic transmission, and brain homeostasis. Ion channel imbalance is one of the widely studied areas in the context of epilepsy and is partially addressed in the abstract. Recent advances in computational neuroscience have led to the development of whole brain network models, providing valuable tools for studying the complex dynamics of epileptic seizures.

Epilepsy, a neurological disorder characterized by recurrent seizures, presents a complex interplay of cellular and molecular mechanisms. The symptoms manifest themselves at various scales, from ion channels to brain regions to behavior in humans. Various screening, treatment, and preventive measures use this knowledge to tackle the disorder effectively. This article aims to summarize the current state of the art in epileptic markers from ion channels, astrocytes, and synaptic imbalance to whole brain Network Dynamics. Recent research has shed light on the critical involvement of astrocytes, the multifunctional glial cells, in the pathogenesis and modulation of epileptic seizures in humans. Astrocytes, once considered as mere supportive cells, are now recognized as active participants in the regulation of neuronal excitability, synaptic transmission, and brain homeostasis. Ion channel imbalance is one of the widely studied areas in the context of epilepsy and is partially addressed in the abstract. Recent advances in computational neuroscience have led to the development of whole brain network models, providing valuable tools for studying the complex dynamics of epileptic seizures.

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