High-resolution electrophysiological mapping of effective connectivity of lateral prefrontal cortex

Auteurs

Avalos-Alais S, Jedynak M, Boyer A, Chanteloup-Forêt B, Pinheiro C, Cline CC, Parmigiani S, Alemán-Gómez Y, Hagmann P, Keller CJ, David O, the F-TRACT Consortium, Adam C, Navarro V, Biraben A, Nica A, Menard D, Brazdil M, Kuba R, Kočvarová J, Pail M, Doležalová I, Dubeau F, Gotman J, Ryvlin P, Isnard J, Catenoix H, Montavont A, Rheims S, Bartolomei F, Trébuchon A, McGonigal A, Zhou W, Wang H, Liu S, Wei Z, Dan Z, Qiang G, Xiangshu H, Hua L, Gang H, Wensheng W, Xi M, Yigang F, Nabbout R, Bourgeois M, Kamińska A, Blauwblomme T, Garcés M, Valentin A, Singh R, Metsähonkala L, Gaily E, Lauronen L, Peltola M, Chassoux F, Landré E, Derambure P, Szurhaj W, Chochois M, Hirsch E, Valenti MP, Scholly J, Valton L, Denuelle M, Curot J, Rocamora R, Principe A, Ley M, Mindruta I, Barborica A, Francione S, Mai R, Nobili L, Sartori I, Tassi L, Maillard L, Vignal JP, Jonas J, Tyvaert L, Chipaux M, Taussig D, Kahane P, Minotti L, Job AS, Michel V, de Montaudoin M, Aupy J, Bouilleret V, Petrescu AM, Masnou P, Dussaule C, Quirins M, Taussig D, Barba C, Guerrini R, Lenge M, Nacci E

Les auteurs en lien sont membres de l'INS.

Équipes

NeuroStim, DynaMap, D-CAP, TNG

Résumé

Abstract The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric disorders. While transcranial brain stimulation treatments often target the LPFC, our current understanding of connectivity profiles guiding these interventions based on electrophysiology remains limited. Here, we present a high-resolution probabilistic map of bidirectional effective connectivity between the LPFC and widespread cortical and subcortical regions. This map is derived from intracranial evoked potential analysis of 48 797 intracranial direct electrical stimulation runs across 759 implantations in 724 patients with refractory epilepsy (368 male, 354 female, two unspecified; mean age ± standard deviation: 24 ± 13.5 years). We mapped probabilistic connectivity between brain parcels with adaptive resolution—higher resolution in the LPFC in the hemisphere of interest and lower elsewhere—maintaining statistical power while achieving 95% average confidence interval of ∼0.03 for connectivity probability estimates. In addition, the signifi

Abstract The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric disorders. While transcranial brain stimulation treatments often target the LPFC, our current understanding of connectivity profiles guiding these interventions based on electrophysiology remains limited. Here, we present a high-resolution probabilistic map of bidirectional effective connectivity between the LPFC and widespread cortical and subcortical regions. This map is derived from intracranial evoked potential analysis of 48 797 intracranial direct electrical stimulation runs across 759 implantations in 724 patients with refractory epilepsy (368 male, 354 female, two unspecified; mean age ± standard deviation: 24 ± 13.5 years). We mapped probabilistic connectivity between brain parcels with adaptive resolution—higher resolution in the LPFC in the hemisphere of interest and lower elsewhere—maintaining statistical power while achieving 95% average confidence interval of ∼0.03 for connectivity probability estimates. In addition, the signifi

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