Frequency‐specific alterations in brain connectivity induced by pulvinar stimulation

Auteurs

Acerbo E, Jegou A, Lagarde S, Pizzo F, Makhalova J, Trébuchon A, Bénar CG, Bartolomei F, Carron R

Les auteurs en lien sont membres de l'INS.

Équipes

DynaMap, D-CAP, NeuroStim

Résumé

Abstract Objective Deep brain stimulation (DBS) is emerging as a promising therapy for patients with drug‐resistant epilepsy, particularly those who are either unsuitable for or unresponsive to resective surgery. The potential benefit of DBS in these patients may stem from its ability to reduce excessive brain functional connectivity (FC). Given that patients undergoing presurgical evaluation in our institution are implanted with stereoelectroencephalographic (SEEG) electrodes in the thalamus, specifically in the pulvinar medialis (PuM), our aim was to investigate the impact of different stimulation frequencies on brain FC. We sought to determine whether specific frequencies were more effective in modulating FC. Methods SEEG was used to investigate the effects of PuM stimulation across a broad frequency range (1–200 Hz) in a cohort of 14 patients with drug‐resistant focal epilepsy. FC was assessed using the nonlinear correlation coefficient ( h 2 ) and node strength calculations. Results Our findings revealed a reduction in FC at stimulation frequencies of 10 Hz and >90 Hz, contrasting with an increase in FC in the 20–80‐Hz range. This modulation of FC extended beyond the epilep

Abstract Objective Deep brain stimulation (DBS) is emerging as a promising therapy for patients with drug‐resistant epilepsy, particularly those who are either unsuitable for or unresponsive to resective surgery. The potential benefit of DBS in these patients may stem from its ability to reduce excessive brain functional connectivity (FC). Given that patients undergoing presurgical evaluation in our institution are implanted with stereoelectroencephalographic (SEEG) electrodes in the thalamus, specifically in the pulvinar medialis (PuM), our aim was to investigate the impact of different stimulation frequencies on brain FC. We sought to determine whether specific frequencies were more effective in modulating FC. Methods SEEG was used to investigate the effects of PuM stimulation across a broad frequency range (1–200 Hz) in a cohort of 14 patients with drug‐resistant focal epilepsy. FC was assessed using the nonlinear correlation coefficient ( h 2 ) and node strength calculations. Results Our findings revealed a reduction in FC at stimulation frequencies of 10 Hz and >90 Hz, contrasting with an increase in FC in the 20–80‐Hz range. This modulation of FC extended beyond the epilep

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