[{"content":"","date":"3 avril 2025","externalUrl":null,"permalink":"/tags/conference/","section":"Tags","summary":"","title":"Conference","type":"tags"},{"content":"Comprendre le cerveau comme un système dynamique : l’INS relie expériences, clinique, neurophysiologie et modélisation pour mieux comprendre le fonctionnement cérébral et ses pathologies.\nDécouvrir les équipes · Voir les publications · Contacter l’Institut\n","date":"3 avril 2025","externalUrl":null,"permalink":"/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Institut de Neurosciences des Systèmes","type":"page"},{"content":"Latest news and updates from the Institut de Neurosciences des Systèmes.\n","date":"3 avril 2025","externalUrl":null,"permalink":"/news/","section":"Latest News","summary":"","title":"Latest News","type":"news"},{"content":"","date":"3 avril 2025","externalUrl":null,"permalink":"/tags/meg/","section":"Tags","summary":"","title":"MEG","type":"tags"},{"content":"This workshop will take place on October 2-3, 2025!\nWe are bringing together leading experts in Optically Pumped Magnetometers (OPMs) to explore their revolutionary applications in non-invasive brain imaging. Topics will range from the latest advances in OPM technology to its potential for enhancing our understanding of the human brain, cognition and clinical applications.\nRegistration is now open! NB: registration is free, but please commit to coming if you register :)\nVenue: Gastaut Amphitheatre of Aix-Marseille University located on the beautiful Pharo site in Marseille, France.\nOrganizing Committee: Victor J. Lopez Madrona, Aurélie Bidet-Caulet, Denis Schwartz, Jean-Michel Badier, Christian-G. Bénar\nLocal Support Team: Audrey Moreau\nPartners and Sponsors: Labels and partner institutes\n","date":"3 avril 2025","externalUrl":null,"permalink":"/news/opms/","section":"Latest News","summary":"","title":"OPMs: The future of magnetoencephalography? - Registration is closed","type":"news"},{"content":"","date":"3 avril 2025","externalUrl":null,"permalink":"/tags/","section":"Tags","summary":"","title":"Tags","type":"tags"},{"content":"Cette collaboration D-CAP–TNG applique l’analyse de variétés neuronales à la perception de la parole et de la musique.\nLire l’article\n","date":"1 janvier 2025","externalUrl":null,"permalink":"/publications/runfola-2025-neural-manifold-flows/","section":"Publications","summary":"L’analyse de variétés neuronales révèle des motifs de complexité lors de l’écoute de la parole et de la musique.","title":"Complexity in speech and music listening via neural manifold flows","type":"publications"},{"content":"","date":"1 janvier 2025","externalUrl":null,"permalink":"/groups/d-cap/","section":"Équipes de recherche","summary":"","title":"D-CAP","type":"groups"},{"content":"L’INS réunit cinq équipes de recherche autour d’une même ambition : comprendre le cerveau comme un système dynamique, de la physiologie cellulaire aux soins. Elles partagent méthodes, plateformes et concepts tout en développant chacune un champ d’expertise propre.\n","date":"1 janvier 2025","externalUrl":null,"permalink":"/groups/","section":"Équipes de recherche","summary":"","title":"Équipes de recherche","type":"groups"},{"content":"","date":"1 janvier 2025","externalUrl":null,"permalink":"/tags/language/","section":"Tags","summary":"","title":"Language","type":"tags"},{"content":"","date":"1 janvier 2025","externalUrl":null,"permalink":"/tags/music/","section":"Tags","summary":"","title":"Music","type":"tags"},{"content":"","date":"1 janvier 2025","externalUrl":null,"permalink":"/tags/neural-manifolds/","section":"Tags","summary":"","title":"Neural-Manifolds","type":"tags"},{"content":"(Theoretical Neurosciences Group)\nThe Theoretical Neuroscience Group (TNG) has a long history. It has been founded in 1999 by Dr. Viktor Jirsa, originally based at the Center for Complex Systems and Brain Sciences at Florida Atlantic University, and then relocated to Aix-Marseille University in 2006. The objective of TNG is to gain a deeper understanding of the mechanisms underlying the emergence of brain function and dysfunction from brain network dynamics. For this purpose, we adopt a \u0026ldquo;multi-scale\u0026rdquo; approach using primarily mathematical and computational techniques. Our approach demands to understand the brain by binding in a single framework different resolution levels, and/or different time scales. This also demands to unify different points of view, from mathematical theory of complex systems toward computer-based numerical simulations (looking at the ensemble activity from the graph of elementary components) and behavioral studies. Our major interests are dedicated to understanding brain states including consciousness, behavioral representation in brain dynamics, and brain network disorders, in particular epilepsy, seen as the prototypical \u0026ldquo;dynamical disorder\u0026rdquo; (as a disorganization of the normal dynamical system). We seek to discover novel ways to modulate brain networks including stimulation, surgery and pharmaceutical interventions.\nTNG TEAM # TEAM LEAD # Viktor JIRSA\nDirector of the Institut de Neurosciences des Systèmes, DR CNRS\nEMAIL: viktor.jirsa@univ-amu.fr PHONE: +33 4 91 32 42 51\nOriginally trained in Theoretical Physics and Philosophy in the 1990s, Dr. Jirsa has made contributions to the understanding of how network structure constrains the emergence of functional dynamics using methods from nonlinear dynamic system theory and computational neuroscience. Dr. Jirsa has been awarded several international and national awards for his research including the Francois Erbsmann Prize in 2001, NASPSPA Early Career Distinguished Scholar Award in 2004, and Grand Prix de Recherche de Provence in 2018. He serves on various Editorial Boards and has published more than 150 scientific articles and book chapters, as well as co-edited several books including the Handbook of Brain Connectivity. Dr. Jirsa is one of the Lead Scientists in the Human Brain Project and The Virtual Brain.\nTEAM MEMBERS # Olivier BLIN | HDR\nSylvie BONIN-GUILLAUME | PU-PH (HDR)\nMarcel CARRERE | MCU\nCatherine CASSE-PERROT | Neuropsychologue\nBorana DOLLOMAJA | Engineer\nElisabeth FRAUGER | PH\nFlorence GAILLARD-BIGOT | Neuropsychiatre\nGaetan GENTILE | MCU\nRomain GUILHAUMOU | PH\nMeysam HASHEMI | Postdoc\nElisabeth JOUVE | Ingénieur APHM\nFarid KHELOUFI | PH\nJoelle MICALLEF | PU-PH (HDR)\nSpase PETKOSKI | Postdoc\nRoland RIZOULIERE | MCU\nPierpaolo SORRENTINO | Postdoc\nJean-Didier Lemarechal | Postdoc\nJan Paul Triebkorn | Doctorant\nLisa Otten | Project Manager\nHuifang WANG | IR2 Inserm\nMarmaduke WOODMAN | IR2 AMU\nXavier ZENDJIDJIAN | PH\nTNG PUBLICATIONS # Wang, H. E., Triebkorn, P., Breyton, M., Dollomaja, B., Lemarechal, J.-D., Petkoski, S., Sorrentino, P., Depannemaecker, D., Hashemi, M., \u0026amp; Jirsa, V. K. (2024). Virtual brain twins: from basic neuroscience to clinical use. National Science Review, 11(5).\nSaggio, M. L., \u0026amp; Jirsa, V. (2024). Bifurcations and bursting in the Epileptor. PLOS Computational Biology, 20(3), e1011903.\nHashemi, M., Ziaeemehr, A., Woodman, M. M., Fousek, J., Petkoski, S., \u0026amp; Jirsa, V. K. (2024). Simulation-based inference on virtual brain models of disorders. Machine Learning: Science and Technology, 5(3), 035019.\nSorrentino, P., Pathak, A., Ziaeemehr, A., Troisi Lopez, E., Cipriano, L., Romano, A., Sparaco, M., Quarantelli, M., Banerjee, A., Sorrentino, G., Jirsa, V., \u0026amp; Hashemi, M. (2024). The virtual multiple sclerosis patient. IScience, 27(7), 110101.\nJirsa, V., Wang, H., Triebkorn, P., Hashemi, M., Jha, J., Gonzalez-Martinez, J., Guye, M., Makhalova, J., \u0026amp; Bartolomei, F. (2023). Personalised virtual brain models in epilepsy. The Lancet Neurology, 22(5), 443–454.\nWang, H. E., Woodman, M., Triebkorn, P., Lemarechal, J.-D., Jha, J., Dollomaja, B., Vattikonda, A. N., Sip, V., Medina Villalon, S., Hashemi, M., Guye, M., Makhalova, J., Bartolomei, F., \u0026amp; Jirsa, V. (2023). Delineating epileptogenic networks using brain imaging data and personalized modeling in drug-resistant epilepsy. Science Translational Medicine, 15(680).\nSorrentino P, Rucco R, Lardone A, Liparoti M, Troisi Lopez E, Cavaliere C, Soricelli A, Jirsa V, Sorrentino G, Amico E. Clinical connectome fingerprints of cognitive decline. Neuroimage. 2021 Sep;238:118253.\nArbabyazd L, Shen K, Wang Z, Hofmann-Apitius M, Ritter P, McIntosh AR, Battaglia D, Jirsa V. Virtual Connectomic Datasets in Alzheimer\u0026rsquo;s Disease and Aging Using Whole-Brain Network Dynamics Modelling. eNeuro. 2021 Jul 6;8(4):ENEURO.0475-20.2021.\nSip V, Scholly J, Guye M, Bartolomei F, Jirsa V. Evidence for spreading seizure as a cause of theta-alpha activity electrographic pattern in stereo-EEG seizure recordings. PLoS Comput Biol. 2021 Feb 26;17(2):e1008731.\nSip V, Hashemi M, Vattikonda AN, Woodman MM, Wang H, Scholly J, Medina Villalon S, Guye M, Bartolomei F, Jirsa VK. Data-driven method to infer the seizure propagation patterns in an epileptic brain from intracranial electroencephalography. PLoS Comput Biol. 2021 Feb 17;17(2):e1008689.\nWang HE, Scholly J, Triebkorn P, Sip V, Medina Villalon S, Woodman MM, Le Troter A, Guye M, Bartolomei F, Jirsa V. VEP atlas: An anatomic and functional human brain atlas dedicated to epilepsy patients. J Neurosci Methods. 2021 Jan 15;348:108983.\nLombardo D, Cassé-Perrot C, Ranjeva JP, Le Troter A, Guye M, Wirsich J, Payoux P, Bartrés-Faz D, Bordet R, Richardson JC, Felician O, Jirsa V, Blin O, Didic M, Battaglia D. Modular slowing of resting-state dynamic functional connectivity as a marker of cognitive dysfunction induced by sleep deprivation. Neuroimage. 2020 Nov 15;222:117155.\nBattaglia D, Boudou T, Hansen ECA, Lombardo D, Chettouf S, Daffertshofer A, McIntosh AR, Zimmermann J, Ritter P, Jirsa V. Dynamic Functional Connectivity between order and randomness and its evolution across the human adult lifespan. Neuroimage. 2020 Nov 15;222:117156.\nSpiegler A, Abadchi JK, Mohajerani M, Jirsa VK. In silico exploration of mouse brain dynamics by focal stimulation reflects the organization of functional networks and sensory processing. Netw Neurosci. 2020 Sep 1;4(3):807-851.\nHashemi M, Vattikonda AN, Sip V, Guye M, Bartolomei F, Woodman MM, Jirsa VK. The Bayesian Virtual Epileptic Patient: A probabilistic framework designed to infer the spatial map of epileptogenicity in a personalized large-scale brain model of epilepsy spread. Neuroimage. 2020 Aug 15;217:116839.\nSaggio ML, Crisp D, Scott JM, Karoly P, Kuhlmann L, Nakatani M, Murai T, Dümpelmann M, Schulze-Bonhage A, Ikeda A, Cook M, Gliske SV, Lin J, Bernard C, Jirsa V, Stacey WC. A taxonomy of seizure dynamotypes. Elife. 2020 Jul 21;9:e55632.\nCourtiol J, Guye M, Bartolomei F, Petkoski S, Jirsa VK. Dynamical Mechanisms of Interictal Resting-State Functional Connectivity in Epilepsy. J Neurosci. 2020 Jul 15;40(29):5572-5588.\n","date":"1 janvier 2025","externalUrl":null,"permalink":"/groups/tng/","section":"Équipes de recherche","summary":"Développer des modèles multi-échelles pour relier la dynamique des réseaux cérébraux à la fonction, aux pathologies et à leurs traitements.","title":"TNG","type":"groups"},{"content":"","date":"1 janvier 2024","externalUrl":null,"permalink":"/tags/alpha-oscillations/","section":"Tags","summary":"","title":"Alpha-Oscillations","type":"tags"},{"content":"","date":"1 janvier 2024","externalUrl":null,"permalink":"/tags/auditory-cortex/","section":"Tags","summary":"","title":"Auditory-Cortex","type":"tags"},{"content":"L’étude distingue des sources alpha évoquées et oscillatoires au sein du cortex auditif humain.\nLire l’article\n","date":"1 janvier 2024","externalUrl":null,"permalink":"/publications/lopez-madrona-2024-alpha-oscillations/","section":"Publications","summary":"Deux sources alpha distinctes dans le cortex auditif humain durant le traitement des sons.","title":"Different sustained and induced alpha oscillations emerge in the human auditory cortex during sound processing","type":"publications"},{"content":"(Dynamical Brain Mapping and Pathophysiology of Focal Human Epilepsies)\nThe main research themes of the DynaMaP team are i) the methodology of brain mapping for epilepsy and cognition (based on EEG, magnetoencephalography and intracerebral EEG) ii) the pathophysiology of human epilepsy. A key feature of the team is to be composed of people with diverse backgrounds (engineers, clinicians, neuroscientists) and to be located within the Timone hospital, which ensures tight collaboration between research and clinics. In the past years, we notably obtained results on the characterization of epileptic networks and on the simultaneous recording of MEG an intracerebral EEG.\nWe are part of large-scale projects (RHU Epinov, ERC Galvani). Moreover, the Dynamap team runs the magnetoencephalography platform, which has the IBISA and \u0026ldquo;AMU platform\u0026rdquo; labels, is member of France Life Imaging network, and of several AMU Institutes (NeuroMarseille, Laënnec, Marseille Imaging).\nA particular effort is made towards translation of our work to clinicians and researchers through the multi-platform Anywave software and its associated plugins (epileptogenicity Index, Delphos, Gardel\u0026hellip;), which architecture specifically aims at allowing fast implementation of algorithms to the end users.\nWe obtained recently an A*midex industrial chair, \u0026ldquo;NewMeg Marseille\u0026rdquo;, in collaboration with the Meg4Health company.\nDYNAMAP TEAM # TEAM LEAD # Christian BÉNAR\nDR, INSERM\nEMAIL: christian.benar@univ-amu.fr PHONE: +33 4 91 38 55 77\nI graduated from Ecole Supérieur d\u0026rsquo;Electricité (Supélec) in 1994. I then spent one year as an engineer at the Hospital Saint-Anne in Toulon (with Franck Vidal), and two years as a programmer at Stellate Systems (Montréal, Dir Jean Gotman). I did my PhD under the supervision of Jean Gotman at the Montreal Neurological Institute (MNI). Back to France in 2004, my postdocs were in Marseille (fMRI Center, with Jean-Luc Anton) and in Sophia Antipolis (Maureen Clerc and Theodore Papadopoulo).\nI was appointed researcher Inserm (CR1) in 2006, and Inserm Director of Research (DR2) in 2018 . Since January 2012, I am the leader of the \u0026ldquo;Dynamical Brain Mapping Group\u0026rdquo; here at INS. Since September 2014, I am scientific head of the Marseille MEG platform. Since 2023, I am a member of the scientific council of the Fédération Française de Recherche sur l\u0026rsquo;épilepsie (FFRE) and elected member of the Neurotechnology Task force of international League against Epilepsy (ILAE).\nMy research interest is signal processing applied to brain signals (EEG, MEG, intracerebral EEG), in order to characterize the spatio-temporal dynamics of networks in cognition and disease.\nTEAM MEMBERS # Fabrice BARTOLOMEI | PU-PH (HDR)\nJean Michel BADIER | IR AMU\nFrancesca Bonini | MCU-PH\nJeanne BENOIT | MD, PhD Student\nEya BOURGUIBA | Project Manager\nFlavius BRATU | MD, PhD Student\nZakia Chidhouri | Engineer\nBruno COLOMBET | AI AMU\nBeatrice DESNOUS | MD, PhD\nMaria Fratello | PhD Student\nRaphaël GUEX | Postdoc\nKhoubeib KANZARI | Engineer\nStanislas LAGARDE | MCU-PH, MD PhD\nIsabelle LAMBERT | MD, PhD\nVictor LOPEZ-MADRONA | Postdoc\nSamuel MEDINA | Engineer\nFrancesca PIZZO | MD, PhD\nDidier SCAVARDA | PU-PH (HDR)\nJulia SCHOLLY | MD, PhD\nCapucine RODET | PhD Student\nLou SEROPIAN | Postdoc\nLucas ARRIGHI | PhD Student\nLydia STOUTAH | PhD Student\nPetra CIPOLLA | Engineer\nCamille MAZZARA | Postdoc\nDYNAMAP PUBLICATIONS # Selected Publications # Jedynak, M., et al. (2023) \u0026quot; Variability of Single Pulse Electrical Stimulation Responses Recorded with Intracranial Electroencephalography in Epileptic Patients\u0026quot; Brain Topography\nLópez‐Madrona, Víctor J., et al. \u0026quot; Magnetoencephalography can reveal deep brain network activities linked to memory processes.\u0026quot; Human Brain Mapping 43.15 (2022): 4733-4749.\nSimula, S., Daoud, M., Bénar, C. G., Benquet, P., Ruffini, G., Wendling, F., \u0026amp; Bartolomei, F. (2022). Transcranial current stimulation in epilepsy: A systematic review of the fundamental and clinical aspects. Frontiers in Neuroscience, 1289.\nBénar, C. G., Velmurugan, J., López-Madrona, V. J., Pizzo, F., \u0026amp; Badier, J. M. (2021). Detection and localization of deep sources in magnetoencephalography: A review. Current Opinion in Biomedical Engineering, 18, 100285.\nPizzo F, Roehri N, Medina Villalon S, Trébuchon A, Chen S, Lagarde S, Carron R, Gavaret M, Giusiano B, McGonigal A, Bartolomei F, Badier JM, Bénar CG. Deep brain activities can be detected with magnetoencephalography. Nat Commun. 2019 Feb 27;10(1):971.\nLagarde S, Roehri N, Lambert I, Trebuchon A, McGonigal A, Carron R, Scavarda D, Milh M, Pizzo F, Colombet B, Giusiano B, Medina Villalon S, Guye M, Bénar CG, Bartolomei F. Interictal stereotactic-EEG functional connectivity in refractory focal epilepsies. Brain. 2018 Oct 1;141(10):2966-2980.\nRoehri N, Pizzo F, Lagarde S, Lambert I, Nica A, McGonigal A, Giusiano B, Bartolomei F, Bénar CG. High-frequency oscillations are not better biomarkers of epileptogenic tissues than spikes. Ann Neurol. 2018 Jan;83(1):84-97.\nMedina Villalon S, Paz R, Roehri N, Lagarde S, Pizzo F, Colombet B, Bartolomei F, Carron R, Bénar CG. EpiTools, A software suite for presurgical brain mapping in epilepsy: Intracerebral EEG. J Neurosci Methods. 2018 Jun 1;303:7-15.\nBartolomei F, Lagarde S, Wendling F, McGonigal A, Jirsa V, Guye M, Bénar C. Defining epileptogenic networks: Contribution of SEEG and signal analysis. Epilepsia. 2017 Jul;58(7):1131-1147.\nDYNAMAP RESEARCH # Simultaneous recordings of MEG, EEG and SEEG # Most previous work on the comparison of MEG, EEG and intracerebral EEG was performed on separate recordings. However, this is far from being optimal. Indeed, only simultaneous recordings of surface and depth activity permit to investigate the exact same activity, independently of spontaneous fluctuations that can occur from a session to another (depending on subject state, medication etc). Moreover, simultaneous recordings allow using interevent fluctuations as a source of information on the link between signals, as was done on simultaneous EEG-fMRI.\nWe have shown for the first time the feasibility of trimodal simultaneous recordings: EEG, MEG and SEEG (Dubarry et al., 2014). Technical developments have been proposed in (Badier et al., 2017) and an application to presurgical mapping in (Gavaret et al., 2016). Recently, thanks to the simultaneous intracerebral recordings, we have shown that it is possible to capture the activity of deep structures on MEG (Pizzo et al 2019, López-Madrona et al. 2022).\nBadier JM, Dubarry AS, Gavaret M, Chen S, Trebuchon AS, Marquis P, Regis J, Bartolomei F, Benar CG \u0026amp; Carron R (2017) \u0026ldquo;Technical solutions for simultaneous MEG and SEEG recordings: towards routine clinical use.\u0026rdquo; Physiol Meas 38(10): N118-N127.\nGavaret M, Dubarry AS, Carron R, Bartolomei F, Benar CG \u0026amp; Trébuchon A (2016) \u0026ldquo;Simultaneous SEEG-MEG-EEG recordings overcome the SEEG limited spatial sampling.\u0026rdquo; Epilepsy Res 128: 67:72.\nPizzo F, Roehri N, Medina Villalon S, Trébuchon A, Chen S, Lagarde S, Carron R, Gavaret M, Giusiano B, McGonigal A, Bartolomei F, Badier JM, Bénar CG. Deep brain activities can be detected with magnetoencephalography. Nat Commun. 2019 Feb 27;10(1):971.\nBrain networks in epilepsy and sleep # An active line of research of the team, in collaborations between clinicians and researchers.\n","date":"1 janvier 2024","externalUrl":null,"permalink":"/groups/dynamap/","section":"Équipes de recherche","summary":"Cartographier les réseaux cérébraux de la cognition et de l’épilepsie, en lien étroit avec la clinique et la plateforme MEG de Marseille.","title":"DynaMap","type":"groups"},{"content":"","date":"1 janvier 2024","externalUrl":null,"permalink":"/tags/precision-medicine/","section":"Tags","summary":"","title":"Precision-Medicine","type":"tags"},{"content":"","date":"1 janvier 2024","externalUrl":null,"permalink":"/tags/review/","section":"Tags","summary":"","title":"Review","type":"tags"},{"content":"","date":"1 janvier 2024","externalUrl":null,"permalink":"/tags/seeg/","section":"Tags","summary":"","title":"SEEG","type":"tags"},{"content":"Cette revue présente les fondements et les perspectives cliniques des jumeaux cérébraux virtuels.\nLire l’article\n","date":"1 janvier 2024","externalUrl":null,"permalink":"/publications/wang-2024-virtual-brain-twins/","section":"Publications","summary":"Une synthèse sur les jumeaux cérébraux virtuels, de la recherche fondamentale aux usages cliniques de précision.","title":"Virtual brain twins: from basic neuroscience to clinical use","type":"publications"},{"content":"","date":"1 janvier 2024","externalUrl":null,"permalink":"/tags/virtual-brain/","section":"Tags","summary":"","title":"Virtual-Brain","type":"tags"},{"content":"","date":"22 novembre 2023","externalUrl":null,"permalink":"/tags/ageing/","section":"Tags","summary":"","title":"Ageing","type":"tags"},{"content":"","date":"22 novembre 2023","externalUrl":null,"permalink":"/tags/ebrains/","section":"Tags","summary":"","title":"EBRAINS","type":"tags"},{"content":"","date":"22 novembre 2023","externalUrl":null,"permalink":"/tags/tng/","section":"Tags","summary":"","title":"TNG","type":"tags"},{"content":"A recent study enabled by the EBRAINS research infrastructure has shed light on the intricate relationship between healthy brain ageing and cognitive decline. Researchers from Aix-Marseille University, Forschungszentrum Jülich and Heinrich-Heine University Düsseldorf employed a virtual ageing brain model and were able to replicate age-related functional changes. The results were published in NeuroImage.\nThe mechanisms of cognitive decline and how it varies among individuals are not yet fully understood, but have been associated with changes in white matter tracts and the reorganisation of functional brain networks.\nAs we age, our brain structure changes and this has functional consequences. However, the consequences of a specific structural change can vary across individuals. Due to this phenomenon, older adults may suffer from different levels of cognitive decline, even when they share similar levels of brain atrophy. To better understand the relationship between brain structure and function during ageing, a vast amount of research started to focus on age-related changes in the interaction of specific brain regions, or cognitive brain networks.\nNow, the team from Germany and France used virtual brain models to investigate the causal link between white matter degeneration and functional changes with the aim of better understanding how structural changes are associated with the interindividual variability of cognitive decline. Virtual brain technology enables the simulations of a person\u0026rsquo;s brain activity using a digital twin, derived from the individual\u0026rsquo;s own brain imaging data.\nThe researchers made use of a large dataset derived from the population-based cohort study \u0026ldquo;1000BRAINS\u0026rdquo; carried out at Forschungszentrum Jülich. The study includes more than 1,000 participants aged 55-85 who have been examined by magnetic resonance imaging (MRI), generating an unprecedented amount of data on brain connectivity, both structural and functional. Systematically analysing this data, the researchers identified specific structural changes associated with ageing.\nBased on the detailed dataset about structural variability, the researchers then generated virtual brain models in order to simulate the functional consequences of structural changes associated with ageing. Their work was enabled by a link between the Multilevel Human Brain Atlas and The Virtual Brain (TVB) simulator, both of which are openly available on EBRAINS.\nIn the Virtual Brain Aging model, they introduced specific structural changes, namely, the degradation between the brain\u0026rsquo;s hemispheres, and then simulated brain activity. Analysing the patterns of brain activity, they observed the same functional changes that they found across the ageing process in the empirical data of the participants of the 1000BRAINS study. Specifically, they were able to reproduce in silico the more global integration of functional brain networks during ageing, a process called \u0026ldquo;functional dedifferentiation\u0026rdquo;.\nIn reaction to the interhemispheric fiber tract decline, the model predicted a shift of the optimal working point of the whole system brain towards higher values, i.e. more network interaction. This shift of the optimal working point related to the cognitive decline of the subjects, thus supporting the hypothesis that this specific structural degeneration was indeed causally linked to cognitive decline – at least on a group level.\nTo understand whether this effect could also be observed on the individual level, the researchers generated an entire cohort of virtual brains, each based on the data from one single subject of the 1000BRAINS study. They found that the individual structural changes led to the hypothesised functional effects in each individual, confirming and extending the group-level predictions to individual level. But they also correctly predicted functional decline to be more pronounced in some than in others, despite the same amount of structural change.\nTaken together, by manipulating brain structure in the computer, the researchers replicated in silico the observed trajectory of white matter decline that they observed empirically, and saw the same trends for the ageing trajectories as well as for the simulated ageing cohort.\nThese results might be the first mechanistic demonstration of the dedifferentiation hypothesis, which suggests that a breakdown of the specific architecture of functional brain networks and their more wide-spread linkage throughout the entire brain during ageing contributes to cognitive decline.\nThis study shows the first results from virtual ageing models based on empirical imaging and cognitive data from a large population-based sample of older adults. The Virtual Aging Brain pipeline is available for usage through EBRAINS.\nThe virtual aging brain: Causal inference supports interhemispheric dedifferentiation in healthy aging Mario Lavanga, Johanna Stumme, Bahar Hazal Yalcinkaya, Jan Fousek, Christiane Jockwitz, Hiba Sheheitli, Nora Bittner, Meysam Hashemi, Spase Petkoski, Svenja Caspers, Viktor Jirsa. NeuroImage, Volume 283, 2023, 120403 https://doi.org/10.1016/j.neuroimage.2023.120403\n","date":"22 novembre 2023","externalUrl":null,"permalink":"/news/virtual-ageing-brain-model/","section":"Latest News","summary":"","title":"Virtual ageing brain model on EBRAINS simulates how our cognition declines during ageing","type":"news"},{"content":"RHU-EPINOV « Improving EPilepsy surgery management and progNOsis using Virtual brain technology»\nClosing Ceremony on November 08th, 2023 at the New Hotel of Marseille\nWinner of the 3rd call for Hospital-University Health Research projects under the French \u0026ldquo;Plan des Investissements d\u0026rsquo;Avenir\u0026rdquo; phase 3 (PIA3) program, the RHU-EPINOV project was launched on January 1, 2018, and funded by the ANR (National Research Agency) with a budget of €5,276,060 over a period of 6 years. The project, coordinated by Professor Fabrice Bartolomei, Head of the Epileptology and Cerebral Rhythmology Department at AP-HM and Head of the Clinical Neurosciences Division, will be completed in its overall financing in December 2023.\nThis innovative project aims to improve the success rate of brain surgery in patients with drug-resistant focal epilepsy. The RHU-EPINOV project facilitated the development of a brain simulation technology based on the modeling of individual patient data, called the Virtual Brain (VEP), developed within the team of Dr. Viktor Jirsa at the Institute of Systems Neuroscience (INSERM/AMU). This technology generates a digital twin of the brain, enabling a better analysis of the epileptogenicity of the brain for a given patient.\nTo validate this approach, the \u0026ldquo;Assistance Publique Hôpitaux de Marseille\u0026rdquo; (AP-HM), partner of the project, initiated a multicenter randomized clinical trial (NCT03643016) involving the participation of 12 epilepsy surgery centers in France, with the inclusion of 356 patients. This prospective and randomized study aims to compare surgical outcomes in terms of seizure frequency between a group having a virtual model and a control group.\nOn November 8, 2023, the official closing ceremony of the project took place at the New Hotel of Marseille, bringing together the consortium partners of the project: Aix-Marseille University (AMU), National Institute of Health and Medical Research (INSERM), Assistance Publique Hôpitaux de Marseille (AP-HM), Dassault Systèmes (3DS), and Hospices Civils de Lyon (HCL). Representatives from SATT Sud-Est (SATT SE) and the startup Virtual Brain Technologies (VBTech) were also present.\nThis event was the occasion to present an overview of the scientific and technological achievements that led to the accomplishment of the objectives of the RHU-EPINOV project, including:\nEstablishment of a world-unique clinical database through the inclusion of 356 patients and the modeling of 166 personalized virtual brain reports for epileptic patients (VEP reports). Development of a stabilized software prototype for clinical use in collaboration with the industrial partner Dassault Systèmes. Advancements in new technologies for high-resolution neuro-computational modeling using non-invasive approaches. Establishment of a startup (VB TECH) for the industrial development of products and licenses related to the epileptic virtual brain. This project led to the development of the first computational model enabling the visualization of brain activity in patients with drug-resistant focal epilepsy. This technology paves the way for the possibility of in silico testing of future therapeutic solutions, such as virtual surgery and non-invasive brain stimulations.\nContact: Prof. Fabrice BARTOLOMEI Coordinator of RHU-EPINOV project Head of the Epileptology and Cerebral Rhythmology Department at AP-HM\n","date":"15 novembre 2023","externalUrl":null,"permalink":"/news/epinov-closing/","section":"Latest News","summary":"","title":"Closing Ceremony of RHU-EPINOV project","type":"news"},{"content":"","date":"15 novembre 2023","externalUrl":null,"permalink":"/tags/dynamap/","section":"Tags","summary":"","title":"Dynamap","type":"tags"},{"content":"","date":"15 novembre 2023","externalUrl":null,"permalink":"/tags/epinov/","section":"Tags","summary":"","title":"Epinov","type":"tags"},{"content":"Paper information: Jirsa, V., Wang, H., Triebkorn, P., Hashemi, M., Jha, J., Gonzalez-Martinez, J., Guye, M., Makhalova, J., \u0026amp; Bartolomei, F. (2023). Personalised virtual brain models in epilepsy. The Lancet Neurology. https://doi.org/10.1016/S1474-4422(23)00008-X\nThere is a comment for our paper: Duncan, J. S., \u0026amp; Taylor, P. N. (2023). Optimising epilepsy surgery. The Lancet Neurology. https://doi.org/10.1016/S1474-4422(23)00082-0\n","date":"12 avril 2023","externalUrl":null,"permalink":"/news/lancet-neurology-review/","section":"Latest News","summary":"","title":"Our review paper in the Lancet Neurology","type":"news"},{"content":"","date":"12 avril 2023","externalUrl":null,"permalink":"/tags/publication/","section":"Tags","summary":"","title":"Publication","type":"tags"},{"content":" Delineating epileptogenic networks using brain imaging data and personalized modeling in drug-resistant epilepsy. # Free access link: https://www.science.org/stoken/author-tokens/ST-984/full\nNote: Currently there is a bug in the referral system where if you click the link twice in the same browser session, the 2nd time the link will display a blank page with only the Science header and footer. If you close the browser session and then reopen the browser, the link will work again. Our web platform is working on fixing this bug.\nPaper information: Wang, H. E., Woodman, M., Triebkorn, P., Lemarechal, J.-D., Jha, J., Dollomaja, B., Vattikonda, A. N., Sip, V., Medina Villalon, S., Hashemi, M., Guye, M., Makhalova, J., Bartolomei, F., \u0026amp; Jirsa, V. (2023). Delineating epileptogenic networks using brain imaging data and personalized modeling in drug-resistant epilepsy. Science Translational Medicine, 15(680). https://doi.org/10.1126/scitranslmed.abp8982\n","date":"26 janvier 2023","externalUrl":null,"permalink":"/news/science-translational-medicine-cover/","section":"Latest News","summary":"","title":"Our cover page paper in Science Translational Medicine","type":"news"},{"content":"","date":"1 janvier 2023","externalUrl":null,"permalink":"/tags/7t-mri/","section":"Tags","summary":"","title":"7T-MRI","type":"tags"},{"content":"","date":"1 janvier 2023","externalUrl":null,"permalink":"/tags/brain-network-medicine/","section":"Tags","summary":"","title":"Brain-Network-Medicine","type":"tags"},{"content":"Cette étude évalue l’usage de modèles cérébraux personnalisés pour délimiter les réseaux épileptogènes chez des personnes atteintes d’épilepsie pharmaco-résistante.\nLire l’article\n","date":"1 janvier 2023","externalUrl":null,"permalink":"/publications/wang-2023-vep/","section":"Publications","summary":"Des jumeaux cérébraux personnalisés pour identifier les réseaux épileptogènes et soutenir la planification chirurgicale.","title":"Delineating epileptogenic networks using brain imaging data and personalized modeling in drug-resistant epilepsy","type":"publications"},{"content":"","date":"1 janvier 2023","externalUrl":null,"permalink":"/tags/epilepsy/","section":"Tags","summary":"","title":"Epilepsy","type":"tags"},{"content":"Cette étude explore la réorganisation sous-corticale dans l’épilepsie focale à l’aide de l’IRM 7T.\nLire l’article\n","date":"1 janvier 2023","externalUrl":null,"permalink":"/publications/makhalova-2023-thalamus/","section":"Publications","summary":"Une étude IRM 7T des altérations structurelles du thalamus et des ganglions de la base dans l’épilepsie focale.","title":"Multi-scale structural alterations of the thalamus and basal ganglia in focal epilepsy using 7T MRI","type":"publications"},{"content":"Cette revue décrit l’émergence d’une médecine des réseaux cérébraux fondée sur des modèles individualisés.\nLire l’article\n","date":"1 janvier 2023","externalUrl":null,"permalink":"/publications/jirsa-2023-personalised-virtual-brain-models/","section":"Publications","summary":"Une revue de référence sur les modèles cérébraux personnalisés appliqués à l’épilepsie.","title":"Personalised virtual brain models in epilepsy","type":"publications"},{"content":"","date":"1 janvier 2023","externalUrl":null,"permalink":"/tags/personalized-medicine/","section":"Tags","summary":"","title":"Personalized-Medicine","type":"tags"},{"content":"","date":"1 janvier 2023","externalUrl":null,"permalink":"/tags/thalamus/","section":"Tags","summary":"","title":"Thalamus","type":"tags"},{"content":"INS news version November 2022.\n","date":"17 novembre 2022","externalUrl":null,"permalink":"/news/ins-news-nov-2022/","section":"Latest News","summary":"","title":"INS news version Nov. 2022","type":"news"},{"content":"SALES CARBONELL Carola, IR TNG I am a passionate Neuroscientist intrigued by the human brain and how it almost magically, produces behavior. Mathematics describes the recipes for neural behavior potions. I obtained a Master\u0026rsquo;s degree in Biomedical Sciences at the University of Antwerp in Belgium and a PhD degree in Neuroscience at the \u0026ldquo;Institut de Neurobiologie de la Méditerranée\u0026rdquo;, University of Aix-Marseille in France. I worked several years as a pre-and post-doctoral experimental and clinical researcher, mainly focus on Autism, Alzheimer\u0026rsquo;s and Parkinson\u0026rsquo;s diseases. Then, I jumped to the other side, the bright side of Neuroscience, and I enrolled in a Master\u0026rsquo;s degree in Mathematical Engineering \u0026amp; Modeling of Neuronal and Cognitive Systems at the \u0026ldquo;Université Côte d\u0026rsquo;Azur\u0026rdquo; in Nice, France. Currently, at the Theoretical Neuroscience Group of the Institute of Systems Neurosciences, I am studying how specific neuronal ensembles operate to cope with the world and maintain us healthy, happy and motivated. Besides Neurosciences, I love Trail running and Classical and Jazz dance. I am also a Clown for children in difficulties, but that\u0026rsquo;s another story\u0026hellip;\nATHANASIADIS Anasthasios, doctorant TNG TNG has given me the opportunity to bring into place my previous knowledge from Physics and Computational Neuroscience with the purpose of understanding and finally contributing to treatments of neurological diseases. My approach is data-driven and lies in describing the topology of the resting state networks. Starting from there we plan to build up by incorporating neuromodulatory processes which have been crucial for the emergence of physical and mental neurological diseases, like Parkinson\u0026rsquo;s disease and Schizophrenia. During the breaks in the lab I enjoy playing chess with my colleagues but in general basketball is my passion. As a Greek person I cannot also hide that I love going to the beach and I am very lucky that Marseille can facilitate this desire. I look forward to summer weather again, even though some people could argue that it still is not bad at all.\n","date":"8 novembre 2022","externalUrl":null,"permalink":"/news/ins-news-oct-2022/","section":"Latest News","summary":"","title":"INS_NEWS version Oct 2022","type":"news"},{"content":"","date":"8 novembre 2022","externalUrl":null,"permalink":"/tags/phd-defense/","section":"Tags","summary":"","title":"Phd Defense","type":"tags"},{"content":"","date":"8 novembre 2022","externalUrl":null,"permalink":"/tags/physionet/","section":"Tags","summary":"","title":"Physionet","type":"tags"},{"content":"Related publication: Simula, S., Daoud, M., Bénar, C. G., Benquet, P., Ruffini, G., Wendling, F., \u0026amp; Bartolomei, F. (2022). Transcranial current stimulation in epilepsy: A systematic review of the fundamental and clinical aspects. Frontiers in Neuroscience, 16, 909421.\n","date":"18 octobre 2022","externalUrl":null,"permalink":"/news/dynamap-simula-daoud/","section":"Latest News","summary":"","title":"New publication from Dynamap by Sara Simula and Maëva Daoud","type":"news"},{"content":"Our last work in the cover of Human Brain Mapping.\nPaper link: https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.25518\n","date":"18 octobre 2022","externalUrl":null,"permalink":"/news/human-brain-mapping-cover/","section":"Latest News","summary":"","title":"Our last work in the cover of Human Brain Mapping","type":"news"},{"content":"","date":"1 janvier 2022","externalUrl":null,"permalink":"/tags/epileptogenesis/","section":"Tags","summary":"","title":"Epileptogenesis","type":"tags"},{"content":"","date":"1 janvier 2022","externalUrl":null,"permalink":"/tags/hippocampus/","section":"Tags","summary":"","title":"Hippocampus","type":"tags"},{"content":"Cette étude longitudinale caractérise l’émergence d’anomalies électrophysiologiques au cours de l’épileptogenèse.\n","date":"1 janvier 2022","externalUrl":null,"permalink":"/publications/bernard-2022-interictal-spikes/","section":"Publications","summary":"Des enregistrements profonds suivent la perte du rythme thêta hippocampique pendant l’épileptogenèse.","title":"Interictal Spike and Loss of Hippocampal Theta Rhythm Recorded by Deep Brain Electrodes during Epileptogenesis","type":"publications"},{"content":"(Physiology \u0026amp; Physiopathology of Brain Networks Team)\nPhysioNet is an interdisciplinary team of researchers pooling expertise from diverse backgrounds (engineering, biology, physics, medicine, mathematics) and aiming to understand the physiology of biological neuronal networks.\nThere are currently three research groups in PhysioNet whose activities overlap and that tackle the understanding of neuronal network physiology at multiple levels, from cellular physiology with patch clamp to neural population recording with extracellular electrophysiology, to whole-brain imaging and modelling.\nTEAM LEAD - Pascale Quilichini # PHONE: +33 4 91 32 42 31\nPHYSIONET TEAM MEMBERS # PIs # Pascale QUILICHINI | CR Inserm Team Leader\nChristophe BERNARD | DR Inserm\nMarco POMPILI | Junior Research Fellow\nLECTURERS RESEARCH ENGINEERS # José BOUCRAUT | MCU CE-PH\nSylvie Thirion | MCU AMU\nAntoine GHESTEM | IE AMU\nAnton IVANOV | IR Inserm\nMathilde NORDLUND | IR AMU\nTRAINEES # Aitakin EZZATI | PhD student (sup. C Bernard, V Jirsa)\nSara SIMULA | Postdoc (sup. M Pompili)\nNariman KIANI | Postdoc (Sup. C Bernard)\nJiaxin LYU | PhD student (Sup. C Bernard, V Jirsa)\nKabeer ABUBAKAR | PhD student (Sup. C Bernard \u0026amp; A Ivanov)\nGabriel MAKDAH | PhD student (Sup. M Pompili, P Quilichini)\nPietro BOZZO | PhD student (Sup. P Quilichini, M Pompili)\nCharles-Edouard QUERLIER | Master Student (Réseaux et télécommunication)\nLaura MARIN | M2 Student (sup. P Quilichini, M Pompili)\nNataly MILAN | PhD student (sup. P Quilichini, C Bernard)\nGuillaume BRUNO | Intern Centrale-Supélec Paris\nLaëtitia COSTA DE BEAUREGARD | Intern Centrale-Supélec Paris\nMatthieu AGUILERA | Postdoc (sup. P Quilichini, C Bernard)\nFORMER MEMBERS # Shunzuke KAJIWARA | PostDoc\nMyriam AZZARELLI | PhD Student\nRichard BOYCE | PostDoc\nMonique ESCLAPEZ | DR Inserm\nOuafae ARAB | AMU IR\nMaëva FERRARIS | PhD Student/PostDoc\nThomas DOUBLET | PostDoc\nArmelle LOKOSSOU | PostDoc\nMatthias DIPPER-WAWRA | PostDoc\nWesley CLAWSON | PhD Student\nYoshi NAKATANI | PhD Student\nAna FERNANDEZ VICENTE | PostDoc\nGalyna MALIEIEVA | PhD Student/PostDoc\nPriya GHUMATKAR | PostDoc\nLoïg KERGOAT | PostDoc\nFrancesca MELLOZI | PhD Student\u0026hellip;\nFORMER INTERNS # Nathan MINOUNI | Centrale-Supélec Paris\nCorrentin LASNE | Centrale-Supélec Paris\nYann ROCHE | Centrale-Supélec Paris\nRaphaël NUNES DA SILVA | Centrale-Supélec Paris\nHugo DEGENEVE | Centrale-Supélec Paris\nValentin GRISEL | Epitech Marseille\nSarah WU | Centrale-Supélec Paris\nPaul-Arno LAMARQUE | Centrale-Supélec Paris\nAndrea Nuti | Scuola Superiore Sant\u0026rsquo; Anna\nNoé Hamou | ESPCI Paris\nBenjamin WAKED | Centrale-Supélec Paris\nEtienne GUEVEL | Centrale-Supélec Paris\nOmar BENJELLOUN | ESPCI Paris\nPHYSIONET RESEARCH # Dynamics of Neuronal Networks and Memory (PI: P. Quilichini) # Cognitive processes depend upon the activity of distributed networks in the brain. We use multiple silicon probes recordings in rodents sampling the network activities and the firing of a large number of neurons in the hippocampus, prefrontal cortex, entorhinal cortex and thalamic nucleus reuniens.\nOur two main goals are:\n(1) Understand the fundamental mechanisms underlying the communication between brain regions controlling memory processes by deciphering how cortico-thalamo-hippocampal networks exchange information to encode and consolidate spatial-related information.\n(2) Understand how these physiological rules are modified in different pathological conditions, such as epilepsy.\nWe use data mining approaches to determine how the dynamics of hundreds of individual neurons and local network oscillations collected in animals performing memory-related tasks can support both memory function and dysfunction.\nMechanisms of cross structural communication (PI: M. Pompili) # We are interested in the dynamics allowing the exchange of information between brain areas, namely how the information encoded in one neural structure is able to modulate the encoding in another area (and the other way around), how these interactions orchestrate perception, learning, and behavior, and how these mechanisms are affected by epilepsy. To do so, our primary experimental approach is to perform high-density recordings of individual neurons simultaneously in multiple brain sites in freely behaving rats and then use data mining and analysis to study neural population dynamics.\nCell and Network Dynamics in physiology and epilepsy (PI: C. Bernard) # Using mathematical and modeling approaches in close collaboration with the TNG team of V. Jirsa, we are studying the basic mechanisms of seizure genesis and propagation across species. We also investigate the mechanisms of vulnerability to epilepsy induced by stress as well as the co-morbidities such as depression, cognitive deficits (memory). We use a multi-disciplinary approach in healthy animals (rats and mice), experimental models of epilepsy (pilocarpine and kainite models) and Alzheimer (APPNL-G-F transgenic mice) in which we couple multisite recordings (in close collaboration with P. Quilichini group) and behavior.\nFigures extracted from:\nFerraris et al (2018) J Neurosci 38(12):3026-3038. \u0026amp; Angulo-Garcia et al (2020) J Neurosci 40:8343-835.\nClawson et al (2023) J Neurosci 43(38: 6573-6587.\nGhestem et al (2023) J. Neural Eng. 20:046003.\nPHYSIONET PUBLICATIONS # Makdah G, Wiener SI, Pompili MN (2025) Detection of Cell Assemblies in High-Density Extracellular Electrophysiological Recordings. In: Carrillo-Reid, L. (eds) \u0026ldquo;Identification, Characterization, and Manipulation of Neuronal Ensembles\u0026rdquo;. Neuromethods vol 215. Springer\nRabuffo G, Lokossou A, Li Z, Ziaee-Mehr A, Hashemi M, Quilichini PP, Ghestem A, Arab O, Esclapez M, Verma P, Raj A, Gozzi A, Sorrentino P, Chuang K, Perles-Barbacaru T, Viola A, Jirsa V, Bernard C (2025) Mapping global brain reconfigurations following local targeted manipulations. PNAS 122(16): e2405706122\nPompili MN, Todorova R, Boucly C, Leroux E, Wiener SI, Zugaro M (2025) Adaptive communication between cell assemblies and \u0026lsquo;reader\u0026rsquo; neurons shapes flexible brain dynamics. PLoS biology 23(12): e3003505\nPompili MN, Eckmier A, Tirole M, Todorova R, Godsil BP, Jay TM (2025) Ventral Hippocampus Modulates Prefrontal Control of Background Contextual Fear After Cued Extinction. European Journal of Neuroscience 62(8): e70287\nMercier O, Quilichini PP, Magalon K, Gil F, Ghestem A, Richard F, Boudier T, Cayre M, Durbec P. (2024) Transient demyelination causes long‐term cognitive impairment, myelin alteration and network synchrony defects. Glia 72 (5), 960-981\nClawson W, Waked B, Madec T, Ghestem A, Quilichini P.P, Battaglia D, Bernard C. (2023). Perturbed Information Processing Complexity in Experimental Epilepsy. J Neurosci 43 (38) 6573-6587.\nBernard, C, Frauscher, B, Gelinas, J, Timofeev, I. (2023) Sleep, oscillations, and epilepsy. Epilepsia 00: 1–10.\nGhestem A, Pompili MN, Dipper-Wawra M, Quilichini PP, Bernard C, Ferraris M (2023) Long-term near-continuous recording with Neuropixels probes in healthy and epileptic rats. Journal of Neural Engeneering 20 046003.\nDoublet T, Ghestem A, Bernard C (2022) Deficit in observational learning in experimental epilepsy. Epilepsia 63 (12), e150-e155.\nPompili MN, Todorova R (2022) Discriminating sleep from freezing with cortical spindle oscillations. Frontiers in Neural Circuits 16: 783768\nRabuffo G, Sorrentino P, Bernard C, Jirsa V (2022) Spontaneous neuronal avalanches as a correlate of access consciousness. Frontiers in Psychology 13, 1008407.\n","date":"1 janvier 2022","externalUrl":null,"permalink":"/groups/physionet/","section":"Équipes de recherche","summary":"Comprendre la physiologie des réseaux neuronaux, de la cellule au cerveau entier, grâce à l’électrophysiologie, l’imagerie et la modélisation.","title":"PhysioNet","type":"groups"},{"content":"","date":"1 janvier 2022","externalUrl":null,"permalink":"/tags/theta/","section":"Tags","summary":"","title":"Theta","type":"tags"},{"content":"","date":"29 septembre 2021","externalUrl":null,"permalink":"/tags/blog/","section":"Tags","summary":"","title":"Blog","type":"tags"},{"content":"The INS Blog features posts from our researchers on their work and the broader field of systems neuroscience.\n","date":"29 septembre 2021","externalUrl":null,"permalink":"/blog/","section":"INS Blog","summary":"","title":"INS Blog","type":"blog"},{"content":"by Pierpaolo Sorrentino, MD, PhD.\nIn the last twenty years or so, the widespread availability of computational power, as well as the diffusion of biomedical devices such as EEG, PET, fMRIs, MEG etc. provided the scientific community with an unprecedented opportunity: to observe the activity of the whole brain as it unfolds. Needless to say, the excitement was huge. It always seemed reasonable to state that the coordination of multiple brain regions underpins behavior. But now, one could finally test this! An entire field formed in the attempt of describing such coordination among areas. However, after years where evidence accumulated very quickly, it also became evident that a clear pattern was lacking. Results would not replicate [1]. In a nerve-wracking race, contradictory evidence accumulated, failing to converge into an overarching framework. Let alone translating these techniques to practical applications! In striking contrast with the successes of structural imaging, functional imaging was left behind, with only a marginal role to play in the Neurological diagnosis. And all this despite major efforts…how did that happen? what went wrong?\nQuite soon, the fact that the statistical analyses were not appropriate for this kind of large dataset became apparent, and this could explain some of the contradictory results. In general, the reliability of the data (i.e. how likely is it that my results would replicate in a different sample? Is making inference reasonable?) became a major concern in the community [2]. Importantly, a great deal of attention was dedicated to the problem of multiple comparisons, whereby spurious results become more likely if one performs multiple statistical tests at once [3]. However, recently, more fundamental aspects that flawed the field became apparent: the \u0026ldquo;validity\u0026rdquo; of the results. That is, provided I found a consistent and reliable statistical pattern in my functional data (as in, the level of activity of two regions appears to be correlated), what would this mean in terms of physiology? Do such patterns really capture some (patho)physiological events taking place within the brain? If so, which ones? Answering these questions is of paramount importance if any external manipulation (i.e. therapeutic intervention) is to be performed. In fact, at the whole-brain level, each signal that we record is generated by a large population of neurons, with an intricate local geometry and a pattern of regional interactions that unfold at the microscopic scale and cannot be observed directly from outside the brain. However, such regional interactions sum up to provide an \u0026ldquo;average\u0026rdquo; local activity, and this is how the signal we are typically dealing with are thought of. Does such \u0026ldquo;average\u0026rdquo; convey the meaningful part of the physiological processes occurring microscopically? Since we lack detailed knowledge of how brain signals are generated, large-scale functional patterns need to predict some behavior in order to be considered valid in neurophysiological terms. Only if the presence of a certain statistical pattern in the signals predicts a behavioral outcome, then such activity might be meaningful.\nThis led to the question, what is the best methodology to extract the activity that is present in the data? In other words, when we look at the data, we are trying to see the traces of what internal mechanisms? What is the right language - the right framework - to listen to what the data are saying?\nAs said, the most straightforward way to analyze activity is to compute correlations. The reasoning behind this reads something like: \u0026ldquo;well, if every time region A gets active, so does region B….and every time region A goes to rest, so does region B…maybe these regions are communicating somehow\u0026rdquo;. As one can see, in this context no statement about the mechanism that might provoke such communication is provided. However, using certain signals (e.g. M/EEG) that are directly generated by neuronal activity, one might choose to go one step further, and study the interactions with the paradigm of synchronization [7]. Synchronization over time needs a certain periodicity in the dynamics to be defined, and it is a mathematical framework that captures if two elements (in this context, brain regions) \u0026ldquo;wait for each other\u0026rdquo;. If one thinks of the activity of brain regions as being oscillating like pendula, and if - over time - such pendula end up \u0026ldquo;swinging\u0026rdquo; together, then one can infer that some interactions are going on. In this context, one is assuming a more physiologically grounded mechanism in order to interpret coherent large-scale activity [8,9]. More recently, however, a further issue rose, since aperiodic, \u0026ldquo;scale-free\u0026rdquo; activity was present in the data [10–12]. If one looked at the data with such new lens, it became apparent that short, aperiodic bursts of activation might carry relevant information about the underlying neuronal microscopic activity, and that such fast transients are not to be discarded, as typically done when assuming periodic activity [13,14]. Interestingly, the spreading of such functional bursts follows the structural tracks linking brain areas that are far apart (connectome) [15], suggesting that the spreading of activity might be indeed mediated by neuronal mechanisms, and convey relevant information [16]. The structural properties of the track affect the velocity of spread of such perturbations, corroborating this interpretation [17].\nAll in all, what is the best way to describe large-scale interactions from data is not yet clear, and multiple approaches might be necessary. However, the circle is now narrowing down. And we are not far from effectively extracting reliable and valid information from the data, in order to address the many theoretical predictions that are waiting to be tested.\nAll in all, we work night and day to provide our community with answers, and finally bring at the side of the Neurologist the remarkable body of knowledge that has been created, in order to build the health-care we dream of, where Neurology is capable of early diagnoses and etiological therapies.\nWe\u0026rsquo;ll try hard, and get there!!\nBibliography [1] Ioannidis, J. P. A. Why Most Published Research Findings Are False. PLoS Med. 2, e124 (2005). [2] Zuo, X.-N., Xu, T. \u0026amp; Milham, M. P. Harnessing reliability for neuroscience research. Nat. Hum. Behav. 3, 768–771 (2019). [3] Chen, X., Lu, B. \u0026amp; Yan, C. Reproducibility of R‐fMRI metrics on the impact of different strategies for multiple comparison correction and sample sizes. Hum. Brain Mapp. 39, 300–318 (2017). [4] Finn, E. S. \u0026amp; Rosenberg, M. D. Beyond fingerprinting: Choosing predictive connectomes over reliable connectomes. NeuroImage 239, 118254 (2021). [5] Sorrentino, P. et al. Clinical connectome fingerprints of cognitive decline. doi:10.1101/2020.10.09.332635. [6] Jirsa, V. Structured Flows on Manifolds as guiding concepts in brain science. in Selbstorganisation – ein Paradigma für die Humanwissenschaften 89–102 (Springer Fachmedien Wiesbaden, 2020). doi:10.1007/978-3-658-29906-4_6. [7] Buzsaki, G. Neuronal Oscillations in Cortical Networks. Science 304, 1926–1929 (2004). [8] Stam, C. J. Modern network science of neurological disorders. Nat. Rev. Neurosci. 15, 683–695 (2014). [9] Fries, P. A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Trends Cogn. Sci. 9, 474–480 (2005). [10] He, B. J. Scale-free brain activity: past, present, and future. Trends Cogn. Sci. 18, 480–487 (2014). [11] Palva, J. M. et al. Neuronal long-range temporal correlations and avalanche dynamics are correlated with behavioral scaling laws. Proc. Natl. Acad. Sci. U. S. A. 110, 3585–3590 (2013). [12] Sorrentino, P. et al. Dynamical interactions of static and moving functional connectivity. In preparation. [13] Friston, K. J. et al. Transients, metastability, and neuronal dynamics. NeuroImage 15, 520–535 (2001). [14] Sorrentino, P. et al. Whole-brain functional connectivity assessed by graph theory and dynamical approaches. In preparation. [15] Ruiz-Garcia, E. et al. Fast spatiotemporal spreading of functional connectivity in the human brain. In preparation. [16] Sorrentino, P. et al. Flexible brain dynamics underpins complex behaviours. In preparation. [17] Jirsa, V. K. et al. Impact of structural connectivity on the propagation of functional bursts. In preparation. [18] Sorrentino, P. \u0026amp; Jirsa, V. K. Clinical markers of dynamical flexibility. In preparation. [19] Deco, G. et al. Perturbation-driven whole-brain dynamics. In preparation.\n","date":"29 septembre 2021","externalUrl":null,"permalink":"/blog/neural-data-language/","section":"INS Blog","summary":"","title":"What language do neural data speak?","type":"blog"},{"content":"On June 24th, Wesley brilliantly defended his PhD.\nCongrats Dr Wes !!!!\n","date":"28 juin 2021","externalUrl":null,"permalink":"/news/phd-clawson/","section":"Latest News","summary":"","title":"A new PhD in PhysioNet :: Dr Clawson !","type":"news"},{"content":"by Mario Lavanga\nCheck it out on his personal blog: https://mlavanga.github.io/blog.html\n","date":"24 février 2021","externalUrl":null,"permalink":"/blog/individual-variability-ageing/","section":"INS Blog","summary":"","title":"Beyond prevention and good practices: how to explain individual variability in ageing","type":"blog"},{"content":"by Hiba Sheheitli\n\u0026ldquo;I would say the beginning is 1666, Isaac Newton is at that point 24 years old, and he has a big year in 1666, more or less invents calculus, figures out the laws of optics, discovers universal gravitation, it\u0026rsquo;s a good year for him, he has other results.. but anyway, as far as our concerns, I mean this is not really true to say that he invented differential equations, but he goes much further with them than anybody else up to that point, and, for the first time in humanity\u0026rsquo;s history, explains the orbits of the planets, that is, Kepler has already calculated from Tycho Brahe\u0026rsquo;s data that the planets move in ellipses along with the other two laws of planetary motion and Newton can explain all of them from universal gravitation plus calculus plus his three laws of motion. So, that is the beginning of dynamics, but then, interestingly, he has solved at that point what we think of as the two-body problem: earth or another planet being pulled by the sun\u0026rsquo;s gravity, that\u0026rsquo;s when he is able to explain elliptical orbits. To do that, he had to neglect all other planets in the solar system or all other objects in the universe, so that\u0026rsquo;s why we call it the two-body problem. But what if there were more bodies? Like if there\u0026rsquo;s the moon or other planets, well, that\u0026rsquo;s the three-body problem or the N-body problem, and Newton can\u0026rsquo;t solve it, and he actually writes to one of his friends that no problem has made his head ache like the problem of the three bodies. So, he does not solve it, neither does anybody else, but people work on it for several hundred years, fast forward to around the late 1800\u0026rsquo;s, it\u0026rsquo;s 1890 by now and still no body has solved the three-body problem, everybody has tried, Euler, all the greats, Gauss… and finally, Poincaré explains what the trouble is, in fact, you can\u0026rsquo;t really solve the three-body problem. So, Poincaré introduces a geometric approach, as opposed to the analytical calculus-based approach… he uses geometry and visualization to supplement calculus and set the stage for modern dynamical systems.\nAs such, the story of the birth of the dynamical systems school of thought is very telling of the powerful role it plays in efforts of understanding complex behavior of nonlinear systems. While Newton knew the exact physical laws governing the motion of planetary bodies, and was able to express those laws as ordinary differential equations, the nonlinear and high-dimensional nature of those equations stood in the way of cracking the behavior of the system; he was unable to obtain specific solutions to describe the motion of the planets given specific parameters and initial conditions. Poincaré\u0026rsquo;s alternative geometric approach was to, instead, ask a different question: what does the space of all possible solutions look like? So, imagine one could represent and visualize the state of the system as a point in an abstract mathematical space, which will be called state space (or phase space), in which the coordinates of that point will be the value of the interacting dependent variables that will vary in time. Then, the behavior of the system can be visualized as the trajectory that such a point will trace in this state space as the system evolves in time. The relevant question then becomes: what does the portrait of all such possible trajectories look like? The aggregation of all possible solutions of the system can then be thought of as a \u0026ldquo;flow\u0026rdquo; that tells us all there is to know about the global dynamics. Think of a bathroom sink, if you wanted to understand the flow of water in it, it is enough to localize the faucets and the drains, no need to follow the individual water molecules, all is repelled away from faucets and attracted into drains.\nSuch is the case in abstract phase space, the global flow of the dynamics will be governed by the existence or absence of repellents and attractors, such as equilibrium points, limit cycles (periodic solutions), strange chaotic attractors, manifolds or other geometric creatures that can live in higher dimensions. The next interesting question would be: how does the number, nature and stability of these latter repellants and attractors depend on system parameters? What bifurcations are possible? Bifurcations being qualitative changes that the flow in phase space can undergo as system parameters are varied, for example, changes in the number or stability of equilibrium points. We can also ask, what is the basin of attraction for each attractor? That is, the set of initial conditions that leads the system to corresponding attracting states. So, it is the big picture of what is happening, the global behavior of our system, that is more of interest and significance than a single instance or trajectory. Dynamical systems theory sets the framework and offers the tools for tackling such questions.\nIn brain science, the first footprints of dynamical systems came with the groundbreaking famous Hodgkin-Huxley model describing the generation and propagation of action potentials in neuronal axons and taking the form of a system of nonlinear differential equations. Serving as the cornerstone for the ever growing biophysical knowledge of neuronal dynamics on the cellular level, it opened the door for a plethora of dynamical systems tools to be deployed for the representation and characterization of the basic features of neuronal dynamics, such as, excitability and threshold behavior, bursting oscillations, synchronization, multistability, hysteresis and spontaneous multiscale spatiotemporal oscillations and organization; dynamical features that are already observed and well understood in numerous other fields and that can be probed and exploited in the study of the less well understood neuronal systems. In this process, a conceptual bridge is built across different fields of study through an underlying universal mathematical milieu that is the machinery of dynamical systems.\nBuilding on such efforts, it is possible to attempt to construct biophysically faithful mathematical models for whole brain dynamics that incorporate individual neuron models. However, with billions of neurons making up a living brain, such models would consist of an extremely high-dimensional system of coupled nonlinear differential equations and would thus pose a somewhat similar difficulty to that faced by Newton in his N-body problem. Admittedly, advancements in high-performance computing, which Newton lacked in his days, enhances the feasibility of simulating such complex nonlinear high dimensional mathematical models, given that we choose specific parameters and initial values. Then, why bother with dynamical systems in brain science?\nJust like the laws of mechanics were necessary but not enough for Newton to conquer the three-body problem, a more global characterization, and a deeper understanding of the fundamental nature of whole brain dynamics, calls here for the equivalent of Poincaré\u0026rsquo;s geometric approach to Newton\u0026rsquo;s N-body problem. An approach that guides the extraction of essential dynamical ingredients starting from the microscale but zooming outwards towards the meso or macro scale, to arrive at representative canonical mathematical models that elucidate core mechanisms behind the rich dynamic repertoire of brain activities and provide more computationally efficient alternative building blocks for whole brain models.\nUltimately, we can write down equations for the highly nonlinear, high-dimensional, complex system that is the brain, and then, a most pressing challenge presents itself: how to explain the enigma of the emergence of order, \u0026ldquo;mind\u0026rdquo; and \u0026ldquo;behavior\u0026rdquo;, out of all that bewildering complexity; that order that manifests as intricate low-dimensional spatiotemporal processes observed in neural signal measurements. Here, dynamical systems theory provides the landscape, jargon and machinery to address this challenge, to construct much needed guiding conceptual frameworks that aim at demystifying the mechanics of the dynamical echoes and shadows of our inner lives.\nTo abstract away from experimental data, of various forms and spatio-temporal scales, into mathematical state space where dynamical systems tools can be wielded to unfold what is not observed but yet governs the observable; herein lies the power of this school of thought. It is an approach that might seem like a feat of artistry but is better viewed as elegant craftmanship that has served science, rigorously, across its various fields and is, undoubtedly, indispensable for its last frontier, the brain.\n","date":"14 février 2021","externalUrl":null,"permalink":"/blog/dynamical-systems-brain-science/","section":"INS Blog","summary":"","title":"Dynamical Systems in Brain Science, why bother?","type":"blog"},{"content":"The Journal of Neuroscience, October 21, 2020 • 40(43):8343–8354\nCell Assemblies in the Cortico-Hippocampal-Reuniens Network during Slow Oscillations # David Angulo-Garcia,* Maëva Ferraris,* Antoine Ghestem, Lauriane Nallet-Khosrofian, Christophe Bernard, and Pascale P. Quilichini\nABSTRACT: The nucleus reuniens (NR) is an important anatomic and functional relay between the medial prefrontal cortex (mPFC) and the hippocampus (HPC). Whether the NR controls neuronal assemblies, a hallmark of information exchange between the HPC and mPFC for memory transfer/consolidation, is not known. Using simultaneous local field potential and unit recordings in NR, HPC, and mPFC in male rats during slow oscillations under anesthesia, we identified a reliable sequential activation of NR neurons at the beginning of UP states, which preceded mPFC ones. NR sequences were spatially organized, from dorsal to ventral NR. Chemical inactivation of the NR disrupted mPFC sequences at the onset of UP states as well as HPC sequences present during sharp-wave ripples. We conclude that the NR contributes to the coordination and stabilization of mPFC and HPC neuronal sequences during slow oscillations, possibly via the early activation of its own sequences.\nFind the PDF at: https://www.jneurosci.org/content/40/43/8343\nDAG, a former TNG Postdoc, is now head of the Grupo de Modelado Computacional, Instituto de Matematicas Aplicadas, Universidad de Cartagena, Cartagena de Indias, 130001, Colombia.\n","date":"20 octobre 2020","externalUrl":null,"permalink":"/news/physionet-cell-assemblies/","section":"Latest News","summary":"","title":"New PhysioNet Publication - Angulo-Garcia, Ferraris et al., JNsci 2020","type":"news"},{"content":" Dynamical Mechanisms of Interictal Resting-State Functional Connectivity in Epilepsy # Julie Courtiol, Maxime Guye, Fabrice Bartolomei, Spase Petkoski and Viktor K. Jirsa\nAbstract # Drug-resistant focal epilepsy is a large-scale brain networks disorder characterized by altered spatiotemporal patterns of functional connectivity (FC), even during interictal resting state (RS). Although RS-FC-based metrics can detect these changes, results from RS functional magnetic resonance imaging (RS-fMRI) studies are unclear and difficult to interpret, and the underlying dynamical mechanisms are still largely unknown. To better capture the RS dynamics, we phenomenologically extended the neural mass model of partial seizures, the Epileptor, by including two neuron subpopulations of epileptogenic and nonepileptogenic type, making it capable of producing physiological oscillations in addition to the epileptiform activity. Using the neuroinformatics platform The Virtual Brain, we reconstructed 14 epileptic and 5 healthy human (of either sex) brain network models (BNMs), based on individual anatomical connectivity and clinically defined epileptogenic heatmaps. Through systematic parameter exploration and fitting to neuroimaging data, we demonstrated that epileptic brains during interictal RS are associated with lower global excitability induced by a shift in the working point of the model, indicating that epileptic brains operate closer to a stable equilibrium point than healthy brains. Moreover, we showed that functional networks are unaffected by interictal spikes, corroborating previous experimental findings; additionally, we observed higher excitability in epileptogenic regions, in agreement with the data. We shed light on new dynamical mechanisms responsible for altered RS-FC in epilepsy, involving the following two key factors: (1) a shift of excitability of the whole brain leading to increased stability; and (2) a locally increased excitability in the epileptogenic regions supporting the mixture of hyperconnectivity and hypoconnectivity in these areas.\nSIGNIFICANCE STATEMENT Advances in functional neuroimaging provide compelling evidence for epilepsy-related brain network alterations, even during the interictal resting state (RS). However, the dynamical mechanisms underlying these changes are still elusive. To identify local and network processes behind the RS-functional connectivity (FC) spatiotemporal patterns, we systematically manipulated the local excitability and the global coupling in the virtual human epileptic patient brain network models (BNMs), complemented by the analysis of the impact of interictal spikes and fitting to the neuroimaging data. Our results suggest that a global shift of the dynamic working point of the brain model, coupled with locally hyperexcitable node dynamics of the epileptogenic networks, provides a mechanistic explanation of the epileptic processes during the interictal RS period. These, in turn, are associated with the changes in FC.\n","date":"22 juillet 2020","externalUrl":null,"permalink":"/news/tng-courtiol/","section":"Latest News","summary":"","title":"New publication from TNG by Courtiol et al. 2020","type":"news"},{"content":" In Vivo Characterization of Neurophysiological Diversity in the Lateral Supramammillary Nucleus during Hippocampal Sharp-wave Ripples of Adult Rats # Ana F. Vicente, Andrea Slézia, Antoine Ghestem, Christophe Bernard and Pascale P. Quilichini\nThe extent of the networks that control the genesis and modulation of hippocampal sharp-wave ripples (SPW-Rs), which are involved in memory consolidation, remains incompletely understood. Here, we performed a detailed in vivo analysis of single cell firing in the lateral supramammillary nucleus (lSuM) during theta and slow oscillations, including SPW-Rs, in anesthetized rats. We classified neurons as SPW-R-active and SPW-R-unchanged according to whether or not they increased their firing during SPW-Rs. We show that lSuM SPW-R-active neurons increase their firing prior to SPW-Rs peak power and prior to hippocampal excitatory cell activation. Moreover, lSuM SPW-R-active neurons show increased firing activity during theta and slow oscillations as compared to unchanged neurons. These results suggest that a sub-population of lSuM neurons can interact with the hippocampus during SPW-Rs, raising the possibility that the lSuM may modulate memory consolidation.\n","date":"20 avril 2020","externalUrl":null,"permalink":"/news/physionet-vicente/","section":"Latest News","summary":"","title":"New publication from Physionet by Vicente et al.","type":"news"},{"content":"","date":"4 mars 2020","externalUrl":null,"permalink":"/tags/dcp/","section":"Tags","summary":"","title":"Dcp","type":"tags"},{"content":" Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy # Jérémy Giroud, Agnès Trébuchon, Daniele Schön, Patrick Marquis, Catherine Liegeois-Chauvel, David Poeppel, Benjamin Morillon\nSpeech processing is now known to be distributed across the two hemispheres, but the origin and function of lateralization continues to be vigorously debated. The asymmetric sampling in time (AST) hypothesis predicts that (1) the auditory system employs a two-timescales processing mode, (2) present in both hemispheres but with a different ratio of fast and slow timescales, (3) that emerges outside of primary cortical regions. Capitalizing on intracranial data from 96 epileptic patients we sensitively validated each of these predictions and provide a precise estimate of the processing timescales. In particular, we reveal that asymmetric sampling in associative areas is subtended by distinct two-timescales processing modes. Overall, our results shed light on the neuro functional architecture of cortical auditory processing.\nYou can find the paper at: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000207\n","date":"4 mars 2020","externalUrl":null,"permalink":"/news/dcp-giroud/","section":"Latest News","summary":"","title":"New DCP Publication by Giroud et. al.","type":"news"},{"content":" Distinct sensitivity to spectrotemporal modulation supports brain asymmetry for speech and melody # Philippe Albouy, Lucas Benjamin, Benjamin Morillon, Robert J. Zatorre\nDoes brain asymmetry for speech and music emerge from acoustical cues or from domain-specific neural networks? We selectively filtered temporal or spectral modulations in sung speech stimuli for which verbal and melodic content was crossed and balanced. Perception of speech decreased only with degradation of temporal information, whereas perception of melodies decreased only with spectral degradation. Functional magnetic resonance imaging data showed that the neural decoding of speech and melodies depends on activity patterns in left and right auditory regions, respectively. This asymmetry is supported by specific sensitivity to spectrotemporal modulation rates within each region. Finally, the effects of degradation on perception were paralleled by their effects on neural classification. Our results suggest a match between acoustical properties of communicative signals and neural specializations adapted to that purpose.\nYou can find the paper at: https://science.sciencemag.org/content/367/6481/1043\n","date":"28 février 2020","externalUrl":null,"permalink":"/news/dcp-albouy/","section":"Latest News","summary":"","title":"New DCP Publication by Albouy et. al.","type":"news"},{"content":" Natural rhythms of periodic temporal attention # Arnaud Zalta, Spase Petkoski and Benjamin Morillon\nIn addition to sustained attention, temporal attention is also governed by a specific sampling rate. In this work, we show with behavior and modeling that humans have a surprisingly limited capacity to flexibly adapt and adjust to the periodic temporal regularities of a scene, either visual or auditory.\nYou can find the paper at: https://www.nature.com/articles/s41467-020-14888-8\n","date":"26 février 2020","externalUrl":null,"permalink":"/news/dcp-tng-zalta/","section":"Latest News","summary":"","title":"New DCP/TNG Publication by Zalta et. al.","type":"news"},{"content":" Neural entrainment to music is sensitive to melodic spectral complexity # Indiana Wollman, Pablo Arias, Jean-Julien Aucouturier, and Benjamin Morillon\nLow-frequency (\u0026lt;10 Hz) cortical neural oscillations are known to entrain to acoustic dynamics - the so-called neural entrainment phenomenon -, but their functional implication in the processing of auditory information remains unclear. In a behavioral and EEG experiment capitalizing on parameterized musical textures, we disentangle the contribution of stimulus dynamics, melodic spectral complexity and emotional judgments on neural entrainment, and highlight their respective spatial and spectral neural signature.\nYou can find the paper at: https://journals.physiology.org/doi/abs/10.1152/jn.00758.2018\n","date":"18 février 2020","externalUrl":null,"permalink":"/news/dcp-wollman/","section":"Latest News","summary":"","title":"New DCP Publication by Wollman et. al.","type":"news"},{"content":"The Predictive Brain Conference will be September 26-27, 2019! This will be the 3rd edition of the INS Conference.\nThe format has been chosen to promote discussion and creativity with special attention to theoretical questions.\nLatest breakthroughs in modeling, cognitive neurosciences, neurophysiology and clinical approaches will provide different insights into a general framework of brain functioning.\nSpecial emphasis will be given to the relation between action and perception, the dynamic nature of neural information and the interactive (brain-environment) nature of predictions.\nVenue: Campus Santé La Timone (Amphithéatre Toga), 27 Bd Jean Moulin, 13005 Marseille, France.\nOrganizing Committee: Daniele Schon, Benjamin Morillon, Mira Didic, Pascale Quilichini, Viktor Jirsa\nLocal Support Team: Véronique Ayala, Conchetta Taverna\n","date":"27 septembre 2019","externalUrl":null,"permalink":"/news/predictive-brain-conference/","section":"Latest News","summary":"","title":"Predictive Brain Conference at INS - Registration is now closed!","type":"news"},{"content":" COMPUTING HUBS IN THE HIPPOCAMPUS AND CORTEX # Wesley Clawson, Ana F. Vicente, Maëva Ferraris, Christophe Bernard, Demian Battaglia and Pascale P. Quilichini\nNeurons in an ensemble perform distinct information processing operations but dynamically switch their roles across states. # Neural computation occurs within large neuron networks in the dynamic context of varying brain states. Whether functions are performed by specific subsets of neurons and whether they occur in specific dynamical regimes remain poorly understood. Using high-density recordings in the hippocampus, medial entorhinal, and medial prefrontal cortex of the rat, we identify computing substates where specific computing hub neurons perform well-defined storage and sharing operations in a brain state-dependent manner. We retrieve distinct computing substates within each global brain state, such as REM and nonREM sleep. Half of recorded neurons act as computing hubs in at least one substate, suggesting that functional roles are not hardwired but reassigned at the second time scale. We identify sequences of substates whose temporal organization is dynamic and stands between order and disorder. We propose that global brain states constrain the language of neuronal computations by regulating the syntactic complexity of substate sequences.\n","date":"27 juin 2019","externalUrl":null,"permalink":"/news/physionet-tng-clawson/","section":"Latest News","summary":"","title":"New Publication from PhysioNet + TNG groups by Clawson et al","type":"news"},{"content":"","date":"24 mars 2019","externalUrl":null,"permalink":"/tags/tvb/","section":"Tags","summary":"","title":"TVB","type":"tags"},{"content":"Get up to speed about the fundamental principles of full brain network modeling using the open-source neuroinformatics platform The Virtual Brain (TVB).\nIn the workshop we will explain the fundamental principles of full brain network modeling using the open source neuroinformatics platform The Virtual Brain (TVB). This simulation environment enables the biologically realistic modeling of network dynamics using connectome-based approaches across different brain scales. Configurable brain network models generate macroscopic neuroimaging signals including functional MRI, intracranial and stereotactic EEG, surface EEG and MEG for single subjects. Researchers from different backgrounds can benefit from an integrative software platform including a supporting framework for data management (generation, organization, storage, integration and sharing) and a simulation core written in Python.\nThe workshop has been strategically scheduled to take place preceding NeuroFrance 2019 that will take place May 22-24, also in Marseille. Optimize your time in Marseille by registering for both events!\nWorkshop Format:\nLectures and hands-on tutorials Participants are encouraged to bring their own data to work on Workshop Program Overview:\nTheoretical background of large scale brain network modeling Architecture of The Virtual Brain Interacting with TVB using GUI and Python CLI (hands-on) Personalization pipeline (TVB-recon) Modeling brain stimulation Clinical applications of The Virtual Brain Modeling epilepsy (hands-on) Data fitting: theoretical background Modeling resting state networks (hands-on) Modeling brain stimulation and mouse brains Mouse simulation (hands-on) Modifying TVB code and implementing new features (hands-on) Optional: bring your own data (optional) Please make sure to register early as we only offer limited seats to ensure there are enough tutors for you. REGISTRATION CLOSES APRIL 29th, 2019.\nIf you need more details about this TVB Node workshop, please contact the local organizer - Lisa Otten\n","date":"24 mars 2019","externalUrl":null,"permalink":"/news/tvb-node-workshop/","section":"Latest News","summary":"","title":"TVB NODE #8 WORKSHOP (MAY 20-21, 2019)","type":"news"},{"content":" ORGANIZATIONAL PRINCIPLES OF MULTIDIMENSIONAL PREDICTIONS IN HUMAN AUDITORY ATTENTION # Anticipating the future rests upon our ability to exploit contextual cues and to formulate valid internal models or predictions. It is currently unknown how multiple predictions combine to bias perceptual information processing, and in particular whether this is determined by physiological constraints, behavioral relevance (task demands), or past knowledge (perceptual expertise). In a series of behavioral auditory experiments involving musical experts and non-musicians, we investigated the respective and combined contribution of temporal and spectral predictions in multiple detection tasks.\nFind the paper here.\n","date":"10 décembre 2018","externalUrl":null,"permalink":"/news/dcp-wollman-morillon/","section":"Latest News","summary":"","title":"New DCP Publication by Wollman \u0026 Morillon","type":"news"},{"content":"A new publication from the DCP group by Rimmele et al.\n","date":"10 décembre 2018","externalUrl":null,"permalink":"/news/dcp-rimmele/","section":"Latest News","summary":"","title":"New Publication from DCP group by Rimmele et al","type":"news"},{"content":" A combined biomarker for epileptogenic tissue # A classical marker of epileptogenic tissues is the interictal epileptiform discharge. Recently, it has been proposed to use high frequency oscillations as a more specific marker. We have shown in our recent publication in Annals of Neurology by Roehri and colleagues that a promising strategy is in fact to combine the two markers in order to improve both sensitivity and specificity.\nFind the paper on PubMed.\n","date":"27 septembre 2018","externalUrl":null,"permalink":"/news/dynamap-roehri/","section":"Latest News","summary":"","title":"New INS Publication by Roehri et. al.","type":"news"},{"content":"New PhysioNet Paper: The nucleus reuniens controls long-range hippocampo-prefrontal gamma synchronization during slow oscillations.\nFerraris M, Ghestem A, Vicente AF, Nallet-Khosrofian L, Bernard C, Quilichini PP.\nThe nucleus reuniens controls long-range hippocampo-prefrontal gamma synchronization during slow oscillations. Journal of Neuroscience 19 February 2018, 3058-17; DOI: https://doi.org/10.1523/JNEUROSCI.3058-17.2018\nABSTRACT # Gamma oscillations are involved in long-range coupling of distant regions which support various cognitive operations. Here we show in adult male rats that synchronized bursts of gamma oscillations bind the hippocampus (HPC) and prefrontal cortex (mPFC) during slow oscillations and slow wave sleep, a brain state that is central for consolidation of memory traces. These gamma bursts entrained the firing of the local HPC and mPFC neuronal populations. Neurons of the nucleus reuniens (NR), which is a structural and functional hub between HPC and mPFC, demonstrated a specific increase in their firing prior to gamma burst onset, suggesting their involvement in HPC-mPFC binding. Chemical inactivation of NR disrupted the temporal pattern of gamma bursts and their synchronization, as well as mPFC neuronal firing. We propose that the NR drives long-range hippocampo-prefrontal coupling via gamma bursts providing temporal windows for information exchange between the HPC and mPFC during slow wave sleep.\nSIGNIFICANCE STATEMENT # Long-range coupling between hippocampus (HPC) and prefrontal cortex (mPFC) is believed to support numerous cognitive functions, including memory consolidation occurring during sleep. Gamma-band synchronization is a fundamental process in many neuronal operations and is instrumental in long-range coupling. Recent evidence highlights the role of nucleus reuniens (NR) in consolidation, however how it influences hippocampo-prefrontal coupling is unknown. In this study, we show that HPC and mPFC are synchronized by gamma bursts during slow oscillations in anesthesia and natural sleep. By manipulating and recording the NR-HPC-mPFC network, we provide evidence that the nucleus reuniens actively promotes this long-range gamma coupling. This coupling provides the hippocampo-prefrontal circuit with a novel mechanism to exchange information during slow wave sleep.\n","date":"27 septembre 2018","externalUrl":null,"permalink":"/news/physionet-ferraris/","section":"Latest News","summary":"","title":"New PhysioNet Paper - Ferraris et al., JNsci 2018","type":"news"},{"content":"","date":"1 janvier 2018","externalUrl":null,"permalink":"/tags/ccep/","section":"Tags","summary":"","title":"CCEP","type":"tags"},{"content":"","date":"1 janvier 2018","externalUrl":null,"permalink":"/tags/connectivity/","section":"Tags","summary":"","title":"Connectivity","type":"tags"},{"content":"","date":"1 janvier 2018","externalUrl":null,"permalink":"/tags/f-tract/","section":"Tags","summary":"","title":"F-TRACT","type":"tags"},{"content":"","date":"1 janvier 2018","externalUrl":null,"permalink":"/tags/gamma/","section":"Tags","summary":"","title":"Gamma","type":"tags"},{"content":"(Brain Stimulation Group)\nOur scientific project is about the study of functional neuroanatomy using neurostimulation and concurrent neurophysiological measurements. By interfering directly with ongoing neural activity through bypassing sensory and other internal input pathways, we mainly aim at 1) identifying and modelling neural substrates of brain function (physiology) and information processing (cognition) and 2) deriving approaches to modulate brain activity in refractory patients with neurological and psychiatric disorders. Research activities are performed in healthy human participants and in patients. Data are processed using state-of-the art signal and image processing techniques (collaboration with DynaMap), and are used to develop large-scale brain models in silico (collaboration with TNG) and to map cognitive and sensori-motor functions (collaboration with D-CAP).\nOur approach is distributed over 2 main axes:\nFunctional brain tractography: During the last decade, we have been developing a research programme (F-TRACT) to infer functional properties of human brain anatomical tracts from the analysis of electrophysiological responses to brief intracerebral and focal electrical stimulations. We work to deliver 1) a whole-brain electrophysiologically informed atlas of the human brain; 2) detailed atlases of functional subsystems (e.g. dorsolateral prefrontal cortex, insula, ventro-medial prefrontal cortex and sensorimotor system); 3) an atlas of large fibre-tracts dynamics; 4) an electrophysiological atlas of brain maturation; 4) stimulation-based software tools to infer epileptogenicity; 5) open-access databases of responses to cortical stimulation.\nCortical excitability: Cortical excitability, defined as the capacity of the brain to respond to transient stimuli, can be measured from direct cortical stimulation but also transcranially, such as using transcranial magnetic stimulation (TMS). In this Axis 2, we thus transpose to non-implanted patients, and to healthy participants, the framework developed in Axis 1 using TMS/EEG to deliver: 1) cortical excitability mapping during cognitive tasks; 2) cortical excitability mapping during the disease\u0026rsquo;s development (e.g. Parkinson de novo) and treatment (e.g. depression); 3) intracranially informed tools to interpret better transcranial measurements and thus to improve therapeutic protocols in patients suffering from refractory neuropsychiatric diseases. In addition, we extend the functional brain tractography approach to study brain and spinal cord synchronisation in acute conditions with direct stimulation of the rootlets to improve surgical procedures for spasticity treatment.\nNEUROSTIM TEAM # TEAM LEAD # Olivier DAVID\nDR, INSERM\nI graduated in applied physics at Ecole Normale Supérieure de Cachan, and got a PhD from Université Paris Sud in signal processing applied to human neurophysiology at CNRS / La Salpêtrière Hospital, under the supervision of Line Garnero and Francisco Varela. I did a post-doc at University College London with Karl Friston where I developed Dynamic Causal Modelling for MEG/EEG. In 2005, I obtained an INSERM researcher position at Grenoble Institute of Neuroscience, France. Since 2011, I have been leading a research group focused on preclinical and clinical neurophysiology in refractory neurological and psychiatric disorders, with a particular interest in the effects of brain stimulation on functional brain networks. I moved full-time to INS in 2021 and created the Brain Stimulation Group in 2024 to pursue similar lines of research.\nSpontaneous applications to work with us are warmly welcome.\nTEAM MEMBERS # Mireille BONNARD | DR CNRS (HDR)\nRomain CARRON | MCU-PH (HDR)\nOlivier DAVID | DR Inserm (HDR)\nMaciej JEDYNAK | Postdoc\nAnthony BOYER | Postdoc\nSofia AVALOS-ALAIS | PhD student\nPia VAYSSIERE | PhD student\nCristiana PINHEIRO | Postdoc\nFrancesco BORRA | Postdoc\nNEUROSTIM RESEARCH # Functional brain Tractography # Essential functional properties associated with otherwise well-defined brain anatomical tracts such as the directionality and latency of propagation across them are largely unknown in human. We proposed they could be inferred from the analysis of brain electrophysiological responses to brief focal electrical stimulations, in combination to structural imaging. By gathering such data in implanted patients suffering from epilepsy explored during SEEG exams and who underwent direct electrical stimulation at low frequency (1 Hz), we have developed the first atlas of functional tractography of the human cerebral cortex. The first version of the atlas was delivered in 2017 on the website of the F-TRACT project initially funded by ERC and then by the Human Brain Project (HBP). Those clinical data were obtained retrospectively and prospectively from a network of epilepsy surgery centres distributed worldwide. After extensive data curation processes, we perform data analyses and brain modelling, with applications in neuroanatomy, computational neuroscience, cognitive neuroscience and epileptology. The main feature of F-TRACT data is to show fast propagation cortical pathways. They are thus particularly interesting to improve computational and biophysical brain models at a large scale. Because we provide neurophysiologically-informed asymmetrical connectivity matrices, we allow a paradigm shift in brain modelling.\nThis research was/is supported by EC FP7 ERC F-TRACT (2014-2019); EC Horizon Europe HBP (2018-2023); DFG-ANR (2018-2020); FNSNF Sinergia Precision Mapping (2023-2027); ANR EPICOG (2023-2027); Inserm Booster Programme (2024-2028).\nCortical Excitability # In 2016, we developed a new method aiming at mapping the dynamical properties of cortical microcircuits non-invasively using the coupling between robotized and neuronavigated TMS and EEG, in which we recorded the responses evoked by the stimulation of 18 cortical targets in healthy subjects. Specific data processing methods were then developed to map the neural responses at each cortical target, which showed inter-regional differences with very good interhemispheric reproducibility. We then proposed the concept of functional cytoarchitectonics, assuming that cortical excitability read-outs may be proxys of the underlying cyto-architecture. We are now trying to assess the face validity of this concept by acquiring indirect cytoarchitectonics measurements from 7T multimodal acquisition allowing to estimate cortical layers in healthy subjects (in collaboration with Pr M. Guye, Marseille), and perform robotized and neuronavigated TMS/EEG in the same subjects. This research is part of the FrontalProbe project funded by NIH\u0026amp;ANR, which is performed with Pr C. Keller, psychiatrist at Stanford University. This project mainly aims at combining TMS/EEG and SEEG information to improve our knowledge of the dorsolateral prefrontal cortex neuroanatomy for optimizing tailored brain stimulation approaches in depression. We also use our robotized rTMS/EEG facility to perform cognitive studies in healthy subjects, in collaboration with local CNRS researchers (C. Pattamadilok, Laboratoire Parole et Langage, Aix en Provence; X. Alario, Laboratoire Psychologie Cognitive, Marseille; A. Montagnini, Institut Neurosciences de la Timone, Marseille).\nThis research was/is supported by ANR Oscilloscopus (2016-2020); IDEX NeuroCog (2017-2021); Labex ILCB (2022-2024); ANR-NIH CRCNS FrontalProbe (2022-2026).\nCortico-spinal integration # Little is known about how sensorimotor information is dynamically integrated by the spinal cord to ensure appropriate motor command between the brain and muscles. Inappropriate cortico-spinal integration can lead to spasticity, a condition in which muscles stiffen or tighten, preventing normal fluid movement. In children, selective dorsal rhizotomy can be proposed to alleviate r\n","date":"1 janvier 2018","externalUrl":null,"permalink":"/groups/neurostim/","section":"Équipes de recherche","summary":"Étudier et moduler les réseaux cérébraux avec la neurostimulation, les mesures neurophysiologiques et des modèles à grande échelle.","title":"NeuroStim","type":"groups"},{"content":"Cet article décrit l’atlas F-TRACT de connectivité cortico-corticale fonctionnelle.\nLire l’article\n","date":"1 janvier 2018","externalUrl":null,"permalink":"/publications/trebaul-2018-functional-tractography/","section":"Publications","summary":"Atlas de tractographie fonctionnelle probabiliste construit à partir de stimulations intracérébrales.","title":"Probabilistic functional tractography of the human cortex revisited","type":"publications"},{"content":"Cette étude met en évidence le rôle du noyau reuniens dans la communication à longue distance pendant les oscillations lentes.\nLire l’article\n","date":"1 janvier 2018","externalUrl":null,"permalink":"/publications/ferraris-2018-nucleus-reuniens/","section":"Publications","summary":"Le noyau reuniens orchestre la synchronisation gamma entre hippocampe et cortex préfrontal.","title":"The nucleus reuniens controls long-range hippocampo-prefrontal gamma synchronization during slow oscillations","type":"publications"},{"content":"Cette revue articule les approches de la SEEG et de l’analyse des signaux pour caractériser les réseaux épileptogènes.\nLire l’article\n","date":"1 janvier 2017","externalUrl":null,"permalink":"/publications/bartolomei-2017-epileptogenic-networks/","section":"Publications","summary":"Une revue sur les réseaux épileptogènes, reliant SEEG, analyse des signaux et connectivité fonctionnelle.","title":"Defining epileptogenic networks: Contribution of SEEG and signal analysis","type":"publications"},{"content":"","date":"1 janvier 2017","externalUrl":null,"permalink":"/tags/epileptor/","section":"Tags","summary":"","title":"Epileptor","type":"tags"},{"content":"","date":"1 janvier 2017","externalUrl":null,"permalink":"/tags/modeling/","section":"Tags","summary":"","title":"Modeling","type":"tags"},{"content":"Cet article pose les bases des modèles de cerveau entier individualisés pour étudier la propagation des crises épileptiques.\nLire l’article\n","date":"1 janvier 2017","externalUrl":null,"permalink":"/publications/jirsa-2017-virtual-epileptic-patient/","section":"Publications","summary":"Article fondateur du Virtual Epileptic Patient et de la modélisation individualisée de la propagation des crises.","title":"The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread","type":"publications"},{"content":"","date":"1 janvier 2015","externalUrl":null,"permalink":"/tags/anywave/","section":"Tags","summary":"","title":"AnyWave","type":"tags"},{"content":"Article de référence du logiciel AnyWave, une plateforme modulaire et multi-plateforme pour les signaux électrophysiologiques.\nLire l’article\n","date":"1 janvier 2015","externalUrl":null,"permalink":"/publications/colombet-2015-anywave/","section":"Publications","summary":"Le logiciel ouvert AnyWave pour visualiser et traiter des signaux EEG, SEEG et MEG.","title":"AnyWave: a cross-platform and modular software for visualizing and processing electrophysiological signals","type":"publications"},{"content":"","date":"1 janvier 2015","externalUrl":null,"permalink":"/tags/electrophysiology/","section":"Tags","summary":"","title":"Electrophysiology","type":"tags"},{"content":"","date":"1 janvier 2015","externalUrl":null,"permalink":"/tags/software/","section":"Tags","summary":"","title":"Software","type":"tags"},{"content":"","date":"1 janvier 2013","externalUrl":null,"permalink":"/tags/simulation/","section":"Tags","summary":"","title":"Simulation","type":"tags"},{"content":"Cet article présente les principes du simulateur The Virtual Brain pour étudier la dynamique des réseaux cérébraux.\n","date":"1 janvier 2013","externalUrl":null,"permalink":"/publications/sanz-leon-2013-the-virtual-brain/","section":"Publications","summary":"Article fondateur du simulateur The Virtual Brain, aujourd’hui intégré à l’écosystème EBRAINS.","title":"The Virtual Brain: a simulator of primate brain network dynamics","type":"publications"},{"content":"\u0026ldquo;The problem of neurology is to understand man himself\u0026rdquo;\n— wilder penfield\nThe Institut de Neurosciences des Systèmes (INS, UMR1106) is a multidisciplinary research institute of Inserm and Aix-Marseille University located on La Timone Campus in Marseille, France. INS members are comprised of academic faculty and clinicians of La Timone Hospital (APHM) institutions, as well as Inserm and CNRS researchers. The research program at INS is focused on understanding the complex dynamics of the brain and altogether, we capitalize on our symbiotic proficiencies by integrating experimental, theoretical and clinical approaches towards understanding brain function and dysfunction.\nINS houses a wide range of state-of-the-art facilities of brain research, which includes the MEG facility, TMS-EEG with a Brain Navigation system, various electrophysiology laboratories, an epileptic patient unit, and The Virtual Brain platform. INS researchers perform research across species ranging from the rodent to the human brain to uncover the mechanisms underlying the functioning of the healthy brain and its disorders, notably epilepsy as the paradigmatic dynamic brain disease.\nAt INS, we combine fundamental theories with innovative approaches in order to conduct high-risk, but promise high-impact findings and results that directly impact . Such innovative projects can only be realized within a unique environment as offered by INS, in which many and distinct competencies ranging from applied mathematics through structural/functional brain imaging to clinical epileptology, are assembled in a single unit.\nIt is here, that the future of neuroscience is now.\nA word from the Director # Dr Viktor Jirsa\nSenior Scientist, Leader Theoretical Neuroscience Group\nModern science is organized around big questions. Well, at least it should be and some of the funding mechanisms recognize this organizational need in order to generate research results with a large impact on society. Large impact typically implies at least one of three components: health, technology and mind-boggling mysteries. The societal impact of the two former is obvious, the latter is more subtle and seems to be linked to the human curiosity about the secrets of our origins, such as the mystery of life, outer space or consciousness. Big questions may thus include how to land on mars; how to cure cancer; or, in our case, how do we think?\nDaring to address each of these questions is scary, necessarily interdisciplinary and needs the tight collaboration and support of scientists, clinicians, engineers, administrators, and policy-makers. Probably the majority of people would agree with these statements. However, when taking a more microscopic view of the current situation, one realizes rapidly that our community works mostly in pluridisciplinary, rather than interdisciplinary environments, and focusses on a variety of questions within the same domain, but not necessarily working on the same deliverable, i.e. the answer to a concrete question. It is easy to approve, but non-trivial to realize such an approach, given the complexity and variety of professional, personal, legal, and institutional constraints.\nWhat you find at the Institut de Neuroscience des Systèmes (INS) in Marseille is our best effort to make this real and create an inspiring and dynamic forum to think about brain and behavior, study how the one influences the other, and find ways to heal the link if broken. In order not to get lost and be able to deliver results, we narrowed this down to concrete achievable goals (which you find on the team pages) and had to make choices. Some choices reflect our personal preferences such as music as a paradigm or the use of time-continuous mathematics rather than discrete maps. Other choices reflect methodological necessities to do better what we want to do, such as building novel technologies in Bayesian inference or nano-electronics of neural implants. And finally, others are determined by the resources available within the environment in Marseille, mostly defined by Aix-Marseille University, Inserm, CNRS and AP-HM, but also our integration into the French and European funding system. We gratefully acknowledge the availability of these resources and thank our funders. Within the context of these choices and constraints, I wish to emphasize two organizational principles we adhered to. The first is Open Science. It is rooted in our desire to answering big questions. Big questions necessitate interdisciplinarity. Interdisciplinary research does not know any borders and is Open Science, demanding free sharing of data, knowledge and tools. The second is respect, tolerance and equality. We are committed to creating an inclusive scientific environment, in which everyone has the same opportunities only limited by their individual talent. We promote diversity as a value that enriches our community and helps it thrive.\nWell, this is how I see it and there may be other presentations possible. Please explore our INS website pages to find them all.\nRespectfully,\nViktor Jirsa\nLearn more about INS, here Viktor Jirsa\u0026rsquo;s Interview in French.\n","externalUrl":null,"permalink":"/about/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"About — INS","type":"page"},{"content":"Le service administratif et logistique a pour mission d\u0026rsquo;anticiper les besoins et mobiliser les moyens adaptés à l\u0026rsquo;activité de l\u0026rsquo;INS, dans les domaines de la gestion des ressources humaines, de la gestion financière, de la logistique, du patrimoine et de la communication.\nÉquipe et organisation # Secrétaire générale\nAudrey Moreau est chargée du pilotage, de la supervision et de la coordination du service administratif et logistique. Membre de l\u0026rsquo;équipe de direction et des différentes instances du laboratoire. Elle participe avec les directeurs adjoints à la conception de la politique et des objectifs de l\u0026rsquo;unité et organise leur mise en œuvre dans son périmètre de responsabilité. Elle fait le lien entre l\u0026rsquo;équipe de direction, les équipes de recherche et l\u0026rsquo;ensemble des services des établissements gestionnaires.\nAchats \u0026amp; Gestion financière # Joëlle Forestier coordonne le pole achat et gestion financière en collaboration avec la secrétaire générale. Elle est chargée de la gestion des ressources humaines et financières (achats/missions) de deux équipes de recherche TNG et Physionet.\nMaria Benkasmi est chargée de la gestion des ressources humaines et financières (achats/missions) de deux équipes de recherche D-CAP et NeuroStim.\nClaire Guichard est chargée de la gestion des ressources humaines et financières (achats/missions) pour une équipe de recherche Dynamap.\nAccueil et logistique # Caroline Modéna est chargée du courrier et de l\u0026rsquo;accueil des visiteurs. Elle gère les réservations de salles et d\u0026rsquo;amphithéâtres, les accès campus et laboratoire, les menus travaux. Elle diffuse à la communauté INS les informations générales.\n","externalUrl":null,"permalink":"/administration/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Administration — INS","type":"page"},{"content":"DCP\n","externalUrl":null,"permalink":"/members/agnes-trebuchon/","section":"Membres","summary":"DCP","title":"Agnès Trébuchon","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/aitakin-ezzati/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Aitakin Ezzati","type":"members"},{"content":"My research work focuses on attentional processing and its development throughout childhood. During my PhD, I will investigate the link between the arousal level, which is under the control of the LC-NE system, and the attentional balance, using behavioural measurements, electroencephalography and physiological recordings such as pupil dilation and skin conductance measures.\nDCP\n","externalUrl":null,"permalink":"/members/anne-mathieu/","section":"Membres","summary":"My research work focuses on attentional processing and its development throughout childhood. During my PhD, I will investigate the link between the arousal level, which is under the control of the LC-NE system, and the attentional balance, using behavioural measurements, electroencephalography and physiological recordings such as pupil dilation and skin conductance measures.","title":"Anne Mathieu","type":"members"},{"content":"NeuroStim\n","externalUrl":null,"permalink":"/members/anthony-boyer/","section":"Membres","summary":"NeuroStim","title":"Anthony Boyer","type":"members"},{"content":"PhysioNet\nPhone: 04 91 32 42 55\n2000 to 2007 Antoine was engineer assistant in molecular biology at the JPARC (INSERM U837) in Lille. He had Proteomic works: biochemical diagnoses of various neurodegenerative diseases, and search for markers. Since 2007 he had joined the UMR 751 as engineer (now the Institut de Neurosciences des Systèmes, UMR1106). His research is center on in-vivo electrophysiological recording technics in freely-moving rodents.\n","externalUrl":null,"permalink":"/members/antoine-ghestem/","section":"Membres","summary":"PhysioNet","title":"Antoine Ghestem","type":"members"},{"content":"Anton Ivanov is a research engineer. He is an expert in neuronal electro-physiology, metabolic imaging and molecular sensing. His specialization is a development of research equipment and experimental protocols for simultaneous recording of metabolic and electrophysiological activities in brain preparation ex vivo. He participates actively to the INS research projects, his scientific results were published in more than 20 scientific articles and book chapters.\n","externalUrl":null,"permalink":"/members/anton-ivanov/","section":"Membres","summary":"Anton Ivanov is a research engineer. He is an expert in neuronal electro-physiology, metabolic imaging and molecular sensing. His specialization is a development of research equipment and experimental protocols for simultaneous recording of metabolic and electrophysiological activities in brain preparation ex vivo. He participates actively to the INS research projects, his scientific results were published in more than 20 scientific articles and book chapters.","title":"Anton Ivanov","type":"members"},{"content":"DCP\nEmail : aurelie.bidet-caulet@inserm.fr\nI performed my PhD work on the perception of complex auditory streams in the Brain Dynamics and Cognition lab, in Lyon (France) under the supervision of Dr. Olivier Bertrand. Then, I joined the lab of Pr. RT Knight at the University of California, Berkeley (USA) to explore the brain mechanisms of auditory selective attention. In 2010, I got appointed as an academic researcher at the French National Institute of Health and Medical Research (INSERM) to work in the Lyon Neuroscience Research Center (France). In 2021, I joined the DCP team at the INS in Marseille. My research work focuses on the brain mechanisms of auditory attention in Human, using pupillometry, scalp EEG, intracortical EEG and MEG. More specifically, I investigate the balance between bottom-up and top-down attention during typical development and ageing, and in different pathologies such as migraine, stroke, ADHD… I am particularly interested in the role of oscillatory cortical activities in the communication within and between the brain networks supporting attention.\n","externalUrl":null,"permalink":"/members/aurelie-bidet-caulet/","section":"Membres","summary":"DCP","title":"Aurélie Bidet-Caulet","type":"members"},{"content":"DCP\n","externalUrl":null,"permalink":"/members/aurelie-grandjean/","section":"Membres","summary":"DCP","title":"Aurelie Grandjean","type":"members"},{"content":"Dynamap\nMail: beatrice.desnous@ap-hm.fr\nI am MD, PhD child neurologist. I joined Dynamap team in 2022 and I am implementing a developmental research axis towards a better understanding of early brain function. The objective is to characterize the organization, spatial and temporal dynamics of brain rhythms and networks during normal and pathological development. My research aims i) the identification and understanding of fundamental mechanisms of early neurodevelopment (motor, language and cognitive) ii) identification of early prognostic biomarkers of normal and pathological neurodevelopment.\n","externalUrl":null,"permalink":"/members/beatrice-desnous/","section":"Membres","summary":"Dynamap","title":"Beatrice Desnous","type":"members"},{"content":"DCP\nTwitter\nI am a cognitive neuroscientist interested in auditory neurophysiology and how information is sequentially encoded in the human brain. After a master’s degree in cognitive neurosciences, I performed a PhD at Ecole Normale Supérieure de Paris where I investigated the role of cortical oscillations as instruments of sensory selection, in the context of speech processing. Subsequently I completed two postdoctoral fellowships, at Columbia and McGill Universities, studying the influence of the motor system in auditory perception and its close interdependency with temporal attention. Currently appointed as an academic researcher at Aix-Marseille University, my domain of expertise encompasses brain imaging, advanced signal processing and psychophysics.\n","externalUrl":null,"permalink":"/members/benjamin-morillon/","section":"Membres","summary":"DCP","title":"Benjamin Morillon","type":"members"},{"content":"In my PhD project i\u0026rsquo;m interested to look at the neural dynamics that support the processing of language structure - syntax. Specifically we\u0026rsquo;re using a minimalistic paradigm, making use of small syntactic differences in very basic syntactic relations (between a head and its complement) and we\u0026rsquo;re contrasting the dynamics of the effect between the modalities of perception and production. For this project i\u0026rsquo;m happy to be supervised by Kristof Strijkers (LPL), Benjamin Morillon (INS) and Liina Pylkkänen (NYU).\npersonal webpage\nDCP\n","externalUrl":null,"permalink":"/members/bissera-ivanova/","section":"Membres","summary":"In my PhD project i’m interested to look at the neural dynamics that support the processing of language structure - syntax. Specifically we’re using a minimalistic paradigm, making use of small syntactic differences in very basic syntactic relations (between a head and its complement) and we’re contrasting the dynamics of the effect between the modalities of perception and production. For this project i’m happy to be supervised by Kristof Strijkers (LPL), Benjamin Morillon (INS) and Liina Pylkkänen (NYU).","title":"Bissera Ivanova","type":"members"},{"content":"I graduated in 2020 from Grenoble INP-Ensimag, an engineering school in applied mathematics and computer science. Previous to that I studied at University Grenoble Alpes in mathematics and informatics. My work at INS involves integrating stimulation in virtual brain models and studying it with the goal to better understand the mechanisms of stimulation as a therapy treatment for epilepsy.\n","externalUrl":null,"permalink":"/members/borana-dollomaja/","section":"Membres","summary":"I graduated in 2020 from Grenoble INP-Ensimag, an engineering school in applied mathematics and computer science. Previous to that I studied at University Grenoble Alpes in mathematics and informatics. My work at INS involves integrating stimulation in virtual brain models and studying it with the goal to better understand the mechanisms of stimulation as a therapy treatment for epilepsy.","title":"Borana Dollomaja","type":"members"},{"content":"Phone: 04 91 38 55 40 or +33 4 91 38 55 40\n","externalUrl":null,"permalink":"/members/bruno-colombet/","section":"Membres","summary":"Phone: 04 91 38 55 40 or +33 4 91 38 55 40","title":"Bruno Colombet","type":"members"},{"content":"DynaMaP\nI am a postdoctoral researcher within the NAUTILUS project, which aims to quantify the immediate effects of non-invasive Temporal Interference (TI) stimulation on brain activity in patients with drug-resistant focal epilepsy using intracranial stereoelectroencephalography (SEEG). As patient recruitment for the prospective study is ongoing, I am currently analyzing resting-state SEEG recordings from patients with drug-resistant temporal epilepsy to investigate functional connectivity dynamics and their relationship with cognitive performance.\n","externalUrl":null,"permalink":"/members/camille-mazzara/","section":"Membres","summary":"DynaMaP","title":"Camille Mazzara","type":"members"},{"content":"Dynamap\nI am a PhD student and clinical psychologist specialized in neuropsychology. My research focuses on the cognitive and emotional mechanisms associated with temporal lobe epilepsy. I study emotion regulation and dissociation and their interaction with cognitive processes, particularly attention, using behavioral approaches combined with electrophysiological and physiological measures (EEG, cardiac activity, and skin conductance).\nMail: capucine.RODET@univ-amu.fr\n","externalUrl":null,"permalink":"/members/capucine-rodet/","section":"Membres","summary":"Dynamap","title":"Capucine Rodet","type":"members"},{"content":"Accueil\ngestion logistique ( accès labo, campus, réservation de salles)\n","externalUrl":null,"permalink":"/members/caroline-modena/","section":"Membres","summary":"Accueil","title":"Caroline Modena","type":"members"},{"content":"","externalUrl":null,"permalink":"/categories/","section":"Categories","summary":"","title":"Categories","type":"categories"},{"content":"TNG\n","externalUrl":null,"permalink":"/members/catherine-casse-perrot/","section":"Membres","summary":"TNG","title":"Catherine Casse-Perrot","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/charles-edouard-querlier/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Charles-Edouard Querlier","type":"members"},{"content":"DCP\nI am a Speech and Language Therapist by training (Università La Sapienza, Roma) and clinical experience, passionate about everything that concerns the semantics and pragmatics of dialogue, its development and impairments or differences in clinical populations. This passion has led me first to pursue a master\u0026rsquo;s in Neuroscience, Language and Communication (UCL, London), and then to dive into research with a PhD (Université de Paris) and a postdoc within the Institute of Language, Communication and Brain (Laboratoire Parole et Langage, Aix-en-Provence).My research projects focussed on the semantics and pragmatics of non-speech vocalisations in interaction, taking an interdisciplinary and multimodal approach to the study of language. Especially, my work has aimed to investigate how the use of non-speech vocalisations in interaction can be informative about infants\u0026rsquo; and children\u0026rsquo;s pragmatic development, and contribute to the early identification of delays or differences in the socio-cognitive sphere.\nI am now working with Daniele Schön (INS), in collaboration with Roxane Bertrand and Leonardo Lancia (Laboratoire Parole et Langage, Aix-en-Provence) on studying pragmatics and conversational dynamics in children with cochlear implants and adults within the autistic spectrum. Especially, we aim to investigate similarities and differences between conversational and music interaction, exploring bidirectional parallelisms, influences, and whether practice on the latter might have transferable effects for individuals struggling with the socio-pragmatic aspects of communication at different levels.\nhttps://scholar.google.com/citations?user=ASyZ81EAAAAJ\u0026hl=en\u0026oi=ao\n","externalUrl":null,"permalink":"/members/chiara-mazzocconi/","section":"Membres","summary":"DCP","title":"Chiara Mazzocconi","type":"members"},{"content":"DynaMap - Team Lead\nResearch Gate | MEG wiki | CV\nI graduated from Ecole Supérieur d\u0026rsquo;Electricité (Supélec) in 1994. I then spent one year as an engineer at the Hospital Saint-Anne in Toulon (with Franck Vidal), and two years as a programmer at Stellate Systems (Montréal). I did my PhD under the supervision of Jean Gotman at the Montreal Neurological Institute (MNI). Back to France in 2004, my postdocs were in Marseille (fMRI Center, with Jean-Luc Anton) and in Sophia Antipolis (Maureen Clerc and Theodore Papadopoulo).\nI was appointed researcher INSERM (\u0026ldquo;chargé de recherche 1ère classe\u0026rdquo; ) in 2006. Since january 2012, I am the leader of the \u0026ldquo;Dynamical Brain Mapping Group” here at INS. Since September 2014, I am scientific head of the Marseille MEG platform.\nMy research interest is signal processing applied to brain signals (fMRI, EEG, MEG), in order to characterize the spatio-temporal dynamics of networks in cognition and disease. Currently, our team is working on simultaneous recordings of surface (EEG, MEG) and depth (SEEG) signals.\n","externalUrl":null,"permalink":"/members/christian-benar/","section":"Membres","summary":"DynaMap - Team Lead","title":"Christian Bénar","type":"members"},{"content":"PhysioNet - Team Lead\nPhone: +33 4 91 32 42 49\nChristophe Bernard\u0026rsquo;s main interest is to understand the mechanisms underlying the construction of an epileptic brain as well as the mechanisms underlying seizure genesis and propagation, focusing on Temporal Lobe Epilepsy (TLE). These research themes are being addressed using a wide array of disciplines, including electron microscopy, morphology, immunohistochemistry, in vitro and in vivo electrophysiology, behavior, mathematics and modeling. When the techniques were not available within the group (e.g. molecular biology), external collaborations have been developed. More recently, we started to design the tools necessary for some of our research programs. For example, we designed a recording device based on organic transistors, which outperforms any other recording device for field potential measurements. We also developed The Virtual Mouse Brain platform. Over the years, using experimental models of TLE, our group has developed a solid international reputation in the field of epilepsy.\nChristophe Bernard was awarded the Michael Prize for epilepsy in 2007 and the Felix Innovation Prize in 2013 for the organic transistor. He isinvited to give between 5 and 15 lectures/keynotes every year. He is Editor in Chief of eNeuro, the open access Neuroscience journal of the Society for Neuroscience (SfN) and past reviewing editor for Science and Journal of Neuroscience.\n","externalUrl":null,"permalink":"/members/christophe-bernard/","section":"Membres","summary":"PhysioNet - Team Lead","title":"Christophe Bernard","type":"members"},{"content":"DCP\n","externalUrl":null,"permalink":"/members/clement-sauvage/","section":"Membres","summary":"DCP","title":"Clément Sauvage","type":"members"},{"content":"Aix-Marseille University Faculty of Medicine, 27, Boulevard Jean Moulin 13005 Marseille, France\nCONTACT US # If you have questions for us about the institute or require assistance from our staff, we invite you to contact us. Please provide as much information as possible in your message so we can best assist you.\nAdministration # Audrey MOREAU, Secrétaire Générale : audrey.moreau@univ-amu.fr, 04 91 32 49 13 Caroline MODENA, Accueil et gestion logistique : caroline.modena@univ-amu.fr, 04 91 32 42 21 Joëlle FORESTIER, Gestionnaire administrative : joelle.forestier@univ-amu.fr, 04 91 32 41 03 Maria BENKASMI, Gestionnaire administrative : maria.benkasmi@univ-amu.fr, 04 91 32 42 51 Claire GUICHARD, Gestionnaire administrative : claire.guichard@univ-amu.fr, 04 91 32 42 39 Getting to INS (Faculty of Medicine and La Timone Hospital) # VIA CITY TRANSPORT - RTM | Timone station is halfway between St Charles train station and La Fouragère, Line 1. You can also reach the Timone site by Bus, 14, 40, 54, 72, 91. Metro/Bus journey planners and times can be found on the RTM website.\nVIA CAR | There is limited car-parking in Timone Hospital. You need to pay to park your car. There is also a very limited car parking at the Faculty of Medicine. A parking garage is available under the Timone Hospital - parking fees do apply. Check Google Map of the area for more information.\nVIA TRAIN | Once you arrive in Marseille St Charles train station, the fastest way is to get the Metro to \u0026ldquo;Timone\u0026rdquo; Station (10-15 minutes). Map it here.\nVIA AIR | Once you land at the Marseille Provence Airport or MP2, you can either take a taxi to INS (€50-60 | 45-70 min) or take a bus to St Charles train (€8,50 | 30 min) and then get the Metro (RTM) to Timone Station.\nVIA FOOT | Enter the main building of the Faculty of Medicine. You will see the library. Then turn right into a hallway which is divided into three sections. In the red section, please take the elevator to the 5th floor. Exit the elevator and go into the hallway, then make a sharp left and you walk directly towards the INS laboratory and offices. You need to ring at the door and the secretary will open. The INS Seminar Room is located on the same floor, on the right hand side un the corridor.\n","externalUrl":null,"permalink":"/contact/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Contact — INS","type":"page"},{"content":"NeuroStim\n","externalUrl":null,"permalink":"/members/cristiana-pinheiro/","section":"Membres","summary":"NeuroStim","title":"Cristiana Pinheiro","type":"members"},{"content":"(Dynamics of Communication and Auditory Processes Group)\nD-CAP\u0026rsquo;s interdisciplinary research is anchored in two primary axes: auditory neuroscience, emphasizing sounds encoding and auditory attention. And speech, language, and music neurosciences, delving into perception, production, and real-life contexts. Our research is bolstered by a range of methodologies including behavioral studies and various imaging techniques.\nOur translational approach applies advanced science to patient care, including music for therapy, aiding dyslexia, hearing impairment, and ADHD. We are also integrating lab innovations into education to tackle educational disparities.\nFinally, we promote environmental awareness and envision the future of science as being open, sustainable, holistic, and theory-driven.\nThe project of the D-CAP is based on two main axes and combines behavior, multimodal imaging (M/EEG, sEEG, pupillometry\u0026hellip;) and modeling. The first axis is on speech, language and music neuroscience, including perception and production as well as ecologically valid scenarios (language interaction). The second axis is on auditory neuroscience, including work on sound categorization and a strong focus on auditory attention.\nD-CAP is active in terms of translational approach, by applying state-of-the-art science to patient care, in particular with the use of music with children with dyslexia and hearing impairment but also in the diagnosis of ADHD in children. We would like to extend this to the general education that in France is massively suffering from social inequalities. This requires a percolation from the Lab to the school via specific actions coordinated with schools.\nD-CAP is injecting a momentum around neuroscience and environmental issues. How should look the science of tomorrow? Definitely open, certainly more sustainable, possibly slower, less driven by industrial interests and hopefully more holistic by a thoughtful use of the dense literature and theories and less focused on computer power.\nD-CAP TEAM # TEAM MEMBERS # Benjamin MORILLON | DR Inserm (HDR) | D-CAP Team Lead\nAurélie BIDET-CAULET | CR Inserm (HDR)\nDaniele SCHÖN | DR CNRS (HDR)\nAgnes TREBUCHON | PU-PH (HDR)\nMira DIDIC | PH (HDR)\nOlivier FELICIAN | PU-PH (HDR)\nDriss BOUDDSAOUD | DR CNRS (HDR)\nStéphane ROMAN | PH\nManuel MERCIER | IR INSERM\nSophie CHEN | IE Inserm\nVéronique SABADELL | Speech therapist\nVictor LOPEZ-MADRONA | Postdoc\nHugo QUENON | Engineer\nAurélie GRANDJEAN | Postdoc\nChiara MAZZOCCONI | Postdoc\nJacques PESNOT LEROUSSEAU | Postdoc\nPierre Hieu GUILLEMINOT | Postdoc\nPaul LALANDE-ROBERT | PhD Student\nAnne MATHIEU | PhD Student\nEmma BERTHAULT | PhD Student\nClément SAUVAGE | PhD Student\nBissera IVANOVA | PhD Student\nMarie PLEGAT | PhD Student\nLaure DEYNA | PhD Student\nHiroyoshi YAMASAKI | PhD Student\nMaude DENIS | PhD Student\nSabrina RODRIGUES | PhD Student\nGiovanni BELLONI | PhD Student\nTessa CANCIO-PASTOR | PhD Student\nMia BERTOVIC | PhD Student\nD-CAP RESEARCH # The D-CAP projects focus on understanding human auditory and communication processes with a multidisciplinary approach, combining behavior, multimodal brain imaging and modeling:\nAuditory Neuroscience # Investigates top-down and bottom-up dynamical processes in auditory perception, focusing on structure, function, and lateralization of the human auditory cortex.\nInvestigates the neural bases of auditory attention during adulthood and development, particularly in children and adolescents.\nAims to understand how the brain transforms acoustic waveforms into semantically rich sound representations.\nFrom Sound to Cognition and Communication # Explores interpersonal coordination across different sensory modalities and time scales in speech and music processing.\nAssesses the benefits of music training on verbal coordination in various linguistic levels.\nExamines the influence of overt movements on auditory temporal attention and speech comprehension and segmentation.\nEnvisages integrating musical activities in innovative speech therapies and educational research.\nCommunication in Neurodegenerative Disorders # Focuses on communication challenges in patients with Alzheimer\u0026rsquo;s Disease (AD) and Frontotemporal Dementia (FTD).\nCollects longitudinal linguistic and behavioral data to analyze internally and externally generated actions in interpersonal communication.\nNeurosciences in the Anthropocene Era # Engages in epistemological discussions, defining neuroscientific questions relevant to the current climate crisis.\nAdvocates for shared values and sustainable practices within the neuroscience community.\nSELECTED PUBLICATIONS # te Rietmolen, N., Mercier, M., Trebuchon, A., Morillon, B., \u0026amp; Schön, D. (2024). Speech and music recruit frequency-specific distributed and overlapping cortical networks. eLife,13:RP94509.\nZalta, A., Large, E. W., Schon, D., \u0026amp; Morillon, B. (2023). Neural dynamics of predictive timing and motor engagement in music listening. bioRxiv, 2023-04.\nMercier, M. R., Dubarry, A. S., Tadel, F., Avanzini, P., Axmacher, N., Cellier, D., \u0026hellip; \u0026amp; Oostenveld, R. (2022). Advances in human intracranial electroencephalography research, guidelines and good practices. Neuroimage, 119438.\nLerousseau, J. P., Hidalgo, C., Roman, S., \u0026amp; Schön, D. (2022). Does auditory deprivation impairs statistical learning in the auditory modality? Cognition, 222, 105009.\nLerousseau, J. P., Trébuchon, A., Morillon, B., \u0026amp; Schön, D. (2021). Frequency selectivity of persistent cortical oscillatory responses to auditory rhythmic stimulation. Journal of Neuroscience, 41(38), 7991-8006.\nHoyer, R. S., Elshafei, H., Hemmerlin, J., Bouet, R., \u0026amp; Bidet‐Caulet, A. (2021). Why are children so distractible? Development of attention and motor control from childhood to adulthood. Child development, 92(4), e716-e737.\nAlbouy, P., Benjamin, L., Morillon, B., \u0026amp; Zatorre, R. J. (2020). Distinct sensitivity to spectrotemporal modulation supports brain asymmetry for speech and melody. Science, 367(6481), 1043-1047.\nTrébuchon, A., Liegeois-Chauvel, C., Gonzalez-Martinez, J. A., \u0026amp; Alario, F. X. (2020). Contributions of electrophysiology for identifying cortical language systems in patients with epilepsy. Epilepsy \u0026amp; Behavior, 112, 107407.\nElShafei, H. A., Fornoni, L., Masson, R., Bertrand, O., \u0026amp; Bidet-Caulet, A. (2020). What\u0026rsquo;s in your gamma? Activation of the ventral fronto-parietal attentional network in response to distracting sounds. Cerebral Cortex, 30(2), 696-707.\n","externalUrl":null,"permalink":"/groups/dcap/","section":"Équipes de recherche","summary":"Une recherche interdisciplinaire sur l’audition, la parole, le langage et la musique, de l’expérience comportementale aux applications cliniques et éducatives.","title":"D-CAP","type":"groups"},{"content":"DCP - Team Lead\nPhone: +33 4 91 32 41 00\nDaniele Schön studied cello at the Conservatory of Padua (Italy) and then perfected his skills first with Teodora Campagnaro, a student of Antonio Janigro and then with Menahem Meir, a student of Alexandre Alexanian and Pablo Casals. He has played in several ensembles, baroque, classical and jazz with a preference for chamber music and string quartet in particular.\nBefore leaving Italy under the Berlusconian regime, he also studied neuropsychology at the University of Padua. He prepared and obtained a doctorate in neuroscience between Marseille, Trieste and Ljubljana. In 2004, he became a CNRS researcher. He is currently working at the Institute of Systems Neurosciences in Marseille, where he is interested in the links between music, language and the brain with an opening to language pathologies. He believes that the symbiosis between science and technico-industrial innovation has now shifted into a pure and simple subservience relation.\n","externalUrl":null,"permalink":"/members/daniele-schon/","section":"Membres","summary":"DCP - Team Lead","title":"Daniele Schön","type":"members"},{"content":"DynaMap\n","externalUrl":null,"permalink":"/members/didier-scavarda/","section":"Membres","summary":"DynaMap","title":"Didier Scavarda","type":"members"},{"content":"DCP\nResearchgate\nDriss Boussaoud received a MS diploma in Biology \u0026amp; Geology in 1980 from Mohamed 5th University (Morocco), and moved to Lyon (France), were he received his PhD in Neurosciences in 1983 from Claude Bernard, Lyon. After a short stay in Morocco as Assistant Professor (1984-85), he joined the National Institutes of Health in Bethesda (MD, USA), as a post-doc (1986-89) and as a visiting fellow (1990-92). In 1992, he was recruited by the CNRS (Lyon, France) where he has developed his research program on the emergence of function in brain networks using an multidisciplinary approach including neurophysiology, brain imaging and neuropsychology both in health and disease. Over his carrier, Dr Boussaoud has made significant contributions to the anatomy and physiology of the brain networks of vision, action planing, attention and gaze signals, as well as the brain dynamics during learning. His current work focuses on social learning addressing questions such as: how social context modulates neuronal properties? and how do we learn from others? He has authored and co-authored over 80 articles and book chapters, cited over 6000 times, and gave more than 100 international conferences. In addition to these scientific contibutions, Dr Boussaoud has occupied various positions in the CNRS, namely: Founder and Director of the Mediterranean Institute for Cognitive Neurosciences (INCM, UMR6193, Marseille); Member of the National Advisory Committee (comité national, 2004-2009); PI and Coordinator of the French-Moroccan Neuroscience Consortium (2008-2015; 29 laboratories); PI and Coordinator of N€UROMED, FP7 International Cooperation, REGPOT-2009-2 (2009-2013, 26 Institutions from 7 mediterranean countries). Since 2008, Dr Boussaoud has played an active role in the development of cooperation and exchanges among Mediterranean neuroscientists. In particular, he is the founder of the Mediterranean Neuroscience Society – MNS http://www.mnsociety.net/, and has acted as its 1st President (2009-2012).\n","externalUrl":null,"permalink":"/members/driss-bouddsaoud/","section":"Membres","summary":"DCP","title":"Driss Bouddsaoud","type":"members"},{"content":"Here at INS, we advocate for an experience that values continued learning. We offer many opportunities for members to engage with various educational offerings which help to equip everyone with the skills, knowledge and know-how to bolster an unparalleled academic experience.\nPARTNERSHIP WITH NEUROSCHOOL # INS is a member of NeuroSchool at Aix-Marseille Université. More specifically, INS hosts AMU Master\u0026rsquo;s and PhD neuroscience students within the labs of the various research groups, determined by a students specific area of interest. By embedding AMU neuroscience students within a rich research setting during their formative educational experience, said students receive exemplary exposure to the fundamentals of scientific research directly from experts in their respective fields.\nINS SEMINARS # INS Seminars give carte blanche to prestigious invited speakers to present a broad overview of their research achievements in a format accessible to a non-specialist audience of systems and cognitive neuroscientists. The series also includes more informal talks aimed at introducing recent advances in specific fields or presenting technical approaches in greater detail, always preceded by a general contextual introduction and a concise overview of the state of the art.\nFor more information, presentation material, or proposing speakers to invite, please contact the INS seminars organizers:\nins-seminaire-contact@univ-amu.fr\nSEE SEMINARS IN EVENTS CALENDAR\n","externalUrl":null,"permalink":"/educational/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Educational — INS","type":"page"},{"content":"TNG\n","externalUrl":null,"permalink":"/members/elisabeth-frauger/","section":"Membres","summary":"TNG","title":"Elisabeth Frauger","type":"members"},{"content":"TNG\n","externalUrl":null,"permalink":"/members/elisabeth-jouve/","section":"Membres","summary":"TNG","title":"Elisabeth Jouve","type":"members"},{"content":"DCP\nConversation can be described as a coordinative verbal behaviour. Importantly, during conversation multi-level linguistic alignments have been observed, implying a convergence toward a common space between interlocutors. These phenomena seem to facilitate and improve communication. Promoting multi-level alignment could thus lead to improved comprehension between interlocutors. The aim of this thesis project will be to study in children, in a conversational context, the effect of rhythmic activity on interactive alignments, focussing on the linguistic levels that are more sensitive to temporal structure (e.g prosodic and phonetic levels). We will also explore, using EEG recordings, the neural dynamics that subtend these alignment phenomena.\n","externalUrl":null,"permalink":"/members/emma-berthault/","section":"Membres","summary":"DCP","title":"Emma Berthault","type":"members"},{"content":"No specific events currently listed on the events page (empty calendar).\n","externalUrl":null,"permalink":"/events/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Events Calendar","type":"page"},{"content":"Dynamap\nMail: eya.BOURGUIBA@univ-amu.fr\nI majored in Industrial Engineering from the University of Applied Sciences and Technology of Tunisia (INSAT). I joined Dynamap team in 2022 as a Project Manager. I am managing the coordination of the Recherche Hospitalo-Universitaire (RHU) EPINOV project and the ERC Synergy GALVANI project. My work consists mainly on managing the administrative, financial and human resources aspects of the projects, the coordination between the different stakeholders and ensuring the scientific reporting to both national and European funding agencies.\n","externalUrl":null,"permalink":"/members/eya-bourguiba/","section":"Membres","summary":"Dynamap","title":"Eya Bourguiba","type":"members"},{"content":"Fabrice Bartolomei, MD, PhD is a neurologist specialized in epilepsy and Professor at the Aix-Marseille University (France) leading the Epileptology and Clinical Neurophysiology department. He is also member of the Research unit INSERM U1106 (DYNAMAP team). He is particularly involved in the presurgical evaluation of patients with drug resistant epilepsy and is a world leader in the analysis of Stereo-EEG recordings. He has published numerous studies in the field of epilepsy (\u0026gt;300, H index \u0026gt;50), particularly on the concept of “Epileptogenic Networks”. He has for a long time promoted the use of EEG/SEEG analysis and the co-inventor of the “Epileptogenicity Index, a method for assessing epileptogenicity of brain regions. He is currently the director of the “Fédération Hospitalo-Universitaire” FHU “Epinext” that gather 11 INSERM research units and 4 clinical departments into a consortium dedicated to the management and research on drug resistant epilepsies. He is the coordinator of a RHU (Recherche Hospitalo-universitaire, Investissements d’avenir/ANR) “EPINOV” (2018-2023) based on the study of individualized large scale modelling in epilepsy surgery and one of the three principal sinvestigators of the ERC grant “Synergy, Galvani” (2020-2026).\nWebpage: https://en.wikipedia.org/wiki/Fabrice_Bartolomei\n","externalUrl":null,"permalink":"/members/fabrice-bartolomei/","section":"Membres","summary":"Fabrice Bartolomei, MD, PhD is a neurologist specialized in epilepsy and Professor at the Aix-Marseille University (France) leading the Epileptology and Clinical Neurophysiology department. He is also member of the Research unit INSERM U1106 (DYNAMAP team). He is particularly involved in the presurgical evaluation of patients with drug resistant epilepsy and is a world leader in the analysis of Stereo-EEG recordings. He has published numerous studies in the field of epilepsy (\u003e300, H index \u003e50), particularly on the concept of “Epileptogenic Networks”. He has for a long time promoted the use of EEG/SEEG analysis and the co-inventor of the “Epileptogenicity Index, a method for assessing epileptogenicity of brain regions. He is currently the director of the “Fédération Hospitalo-Universitaire” FHU “Epinext” that gather 11 INSERM research units and 4 clinical departments into a consortium dedicated to the management and research on drug resistant epilepsies. He is the coordinator of a RHU (Recherche Hospitalo-universitaire, Investissements d’avenir/ANR) “EPINOV” (2018-2023) based on the study of individualized large scale modelling in epilepsy surgery and one of the three principal sinvestigators of the ERC grant “Synergy, Galvani” (2020-2026).","title":"Fabrice Bartolomei","type":"members"},{"content":"TNG\n","externalUrl":null,"permalink":"/members/farid-kheloufi/","section":"Membres","summary":"TNG","title":"Farid Kheloufi","type":"members"},{"content":"Dynamap\nMail: flavius.bratu@yahoo.com\nI am a Neurologist in training. I obtained the title of Medical Doctor from Carol Davila University of Medicine and Pharmacy, Bucharest, in 2019 (dual degree B.Sc and M.Sc). I have spent most of my residency training in the Epilepsy Monitoring Unit of the Emergency University Hospital Bucharest, which is the heart of the Romanian National Programme for Pharmacoresistant Epilepsy. Since 2022 I am training in the Clinical Neurophysiology Department of Timone Hospital and I am research fellow of DynaMap. My scientific topics include: simultaneous scalp EEG-SEEG studies, autoscopic phenomena, permutation entropy and the postictal state. In the past I have been vice-champion of the International Neuroscience Championship (Cape Town, South Africa, 2012) and laureate for the preselection of the national team representing Romania at the International Biology Olympiad (Bern, Switzerland, 2013).\n","externalUrl":null,"permalink":"/members/flavius-bratu/","section":"Membres","summary":"Dynamap","title":"Flavius Bratu","type":"members"},{"content":"TNG\n","externalUrl":null,"permalink":"/members/florence-gaillard-bigot/","section":"Membres","summary":"TNG","title":"Florence Gaillard-Bigot","type":"members"},{"content":"Dynamap\nEmail : francesca.bonini@univ-amu.fr\n","externalUrl":null,"permalink":"/members/francesca-bonini/","section":"Membres","summary":"Dynamap","title":"Francesca Bonini","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/francesca-pizzo/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Francesca Pizzo","type":"members"},{"content":"NeuroStim\n","externalUrl":null,"permalink":"/members/francesco-borra/","section":"Membres","summary":"NeuroStim","title":"Francesco Borra","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/gabriel-makdah/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Gabriel Makdah","type":"members"},{"content":"TNG\n","externalUrl":null,"permalink":"/members/gaetan-gentile/","section":"Membres","summary":"TNG","title":"Gaetan Gentile","type":"members"},{"content":"My PhD research explores how rhythm shapes human auditory cognition. I aim to determine the ideal tempo for cognitive tasks and uncover the neural processes behind these optimal rhythms. By combining behavioral experiments with high-resolution brain electrophysiology, I directly link cognitive performance to brain activity. This integration provides a comprehensive view of how rhythm influences auditory perception.\n","externalUrl":null,"permalink":"/members/giovanni-belloni/","section":"Membres","summary":"My PhD research explores how rhythm shapes human auditory cognition. I aim to determine the ideal tempo for cognitive tasks and uncover the neural processes behind these optimal rhythms. By combining behavioral experiments with high-resolution brain electrophysiology, I directly link cognitive performance to brain activity. This integration provides a comprehensive view of how rhythm influences auditory perception.","title":"Giovanni Belloni","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/guillaume-bruno/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Guillaume Bruno","type":"members"},{"content":" Human Brain Project Summit 2023 # It is our great pleasure to invite you to the Human Brain Project Summit 2023, which will take place in Marseille, France, on March 28-31, 2023, at the Pharo. We\u0026rsquo;re excited to have an in-person event after our 2021 virtual summit.\nThe upcoming Summit will highlight the excellent scientific achievements of the HBP as the Flagship project approaches its conclusion. Click here to find out more.\nINS is not only involved in the organization of the Summit, but also pre-summit local events who will bring the neuroscience closer to the Marseille community. These include:\nHigh profile talks at the Alcazar Library Workshops at the Semaine du Cerveau (13-19 March) An EBRAINS workshop Science talks at local pubs A scientific image art exhibition at Hexagone - Luminy (27 February - 5 March), Bibliotèque Alcazar (7-31 March) and the Brasserie Zoumai (4 April - 6 May) Events # HBP Picture exhibition - Zoumaï\nDate: Tue, Apr 4, 2023 – Sat, May 6, 2023 Location: Brasserie Zoumaï HBP Summit\nDate: Tue, Mar 28, 2023 – Fri, Mar 31, 2023 Location: Palais du Pharo Website: https://summit2023.humanbrainproject.eu/ Talks with Viktor Jirsa and France Nivelle - Alcazar\nDate: Friday, March 17, 2023, 6:00 PM – 7:00 PM Location: Bibliothèque l\u0026rsquo;Alcazar HBP Picture exhibition - Alcazar\nDate: Tue, Mar 7, 2023 – Fri, Mar 31, 2023 Location: Bibliotèque Alcazar HBP Picture exhibition - Hexagone\nDate: Mon, Feb 27, 2023 – Sun, Mar 5, 2023 Location: l\u0026rsquo;Hexagone - Luminy ","externalUrl":null,"permalink":"/summit/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"HBP Summit - Marseille, 28-31 March 2023","type":"page"},{"content":"DCP\nAim of my PhD project is to better understand the process of convergence between two interlocutors during a naturalistic conversation. To this end we will look at how various behavioural parameters at different levels (phonemic, morphemic, syntactic, discourse level) as well as other physiological parameters (e.g. electrodermal) correlate with neural signal (EEG).\n","externalUrl":null,"permalink":"/members/hiroyoshi-yamasaki/","section":"Membres","summary":"DCP","title":"Hiroyoshi Yamasaki","type":"members"},{"content":"D-CAP\nAfter a degree in computer engineering, I joined the D-CAP team to develop tools for data collection and processing\n","externalUrl":null,"permalink":"/members/hugo-quenon/","section":"Membres","summary":"D-CAP","title":"Hugo Quenon","type":"members"},{"content":"Phone: +33 4 91 32 42 31\nI am an Inserm research engineer who works in INS with Dr. Viktor Jirsa. My current research is interested in personalized whole brain modelling (digital twins) in neurology. Led by Viktor, we have built a virtual epileptic patient pipeline for the diagnosis and treatment of epilepsy. Now we are on the journal to digital twins for the dignosis, treatement and prognosis for epilepsy and other brain disorders. I obtained a PhD in Robotics in 2008 and did my first postdoc in the university of Pisa with Pr. Antonio Bicchi. Then I started my journey in neuroscience to study the functional connectivity of brain networks as a postdoc at INS with Dr. Christophe Bernard in Marseille since 2012 and worked 1 year postdoc in ICM Paris with Pr. Vincent Navarro for single neuron studies.\n","externalUrl":null,"permalink":"/members/huifang-wang/","section":"Membres","summary":"Phone: +33 4 91 32 42 31","title":"Huifang Wang","type":"members"},{"content":" INS videos # Viktor Jirsa Interview about INS in French. TNG videos # Viktor Jirsa: The Virtual Brain and EBrains VEP brain modelling for Epilepsy \u0026mdash; The Next Generation PhysioNet Videos # (No specific videos listed)\nDCP Videos # (No specific videos listed)\nDynamap Videos # (No specific videos listed)\n","externalUrl":null,"permalink":"/videos/","section":"INS Videos","summary":"","title":"INS Videos","type":"videos"},{"content":"DynaMap\nMedical activities : MD in 2013, specialization in Neurology. From 2013 to 2015, clinical practice in the Neuropsychological department (Pr Ceccaldi, memory center, Timone Hospital) and from 2015, clinical practice in sleep medicine in the sleep unit of the Epileptology and Brain Rythmology Department (Pr Bartolomei, Timone Hospital, Marseille). Research activities : In 2010: Master 2 Neuroscience (Integrative and cognitive neuroscience) directed by Dr Catherine Liegeois-Chauvel and Pr Olivier Felician about the study of recognition memory in MEG in patients with Mild Cognitive Impairment. PhD from 2014 (currently I am starting the 5th year) directed by Pr Bartolomei and Dr Benar, in association withe Pr Felician and Dr Tramoni-Negre) about the changes of interictal epileptic activities during sleep and the consequences on the long-term memory consolidation.\n","externalUrl":null,"permalink":"/members/isabelle-lambert/","section":"Membres","summary":"DynaMap","title":"Isabelle Lambert","type":"members"},{"content":"DCP\nJacques Pesnot Lerousseau received a 2023 ILCB post-doc fellowship to work with Benjamin Morillon (INS), in collaboration with Valentin Wyart (ENS) and Jean-Rémi King (ENS). His project will address the question of “in-context learning” in human brains and artificial neural networks, aiming to uncover the mechanisms behind rule generalization in the brain and algorithms.\nAs a PhD student at INS, Jacques focused on temporal predictions in children with cochlear implants, under the supervision of Daniele Schön (INS). Later, as a post-doc at the University of Oxford with Christopher Summerfield (Universtity of Oxford, DeepMind), he developed artificial neural network models to understand how the brain structures auditory and visual information to promote generalization. Jacques’ work bridges auditory perception, computational modelling, and the intersection of neuroscience and artificial intelligence.\n","externalUrl":null,"permalink":"/members/jacques-pesnot-lerousseau/","section":"Membres","summary":"DCP","title":"Jacques Pesnot Lerousseau","type":"members"},{"content":"TNG\nPhone: +33 4 91 32 42 31\n","externalUrl":null,"permalink":"/members/jan-paul-triebkorn/","section":"Membres","summary":"TNG","title":"Jan Paul Triebkorn","type":"members"},{"content":"Phone: +33 4 91 32 42 31\n","externalUrl":null,"permalink":"/members/jean-didier-lemarechal/","section":"Membres","summary":"Phone: +33 4 91 32 42 31","title":"Jean-Didier Lemarechal","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/jean-michel-badier/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Jean-Michel Badier","type":"members"},{"content":"Dynamap\nI am a neurologist with a focus on epilepsy and clinical neurophysiology. My research focuses on signal processing and automated approaches to analyze scalp EEG recordings in patients with epilepsy. My current work aims to develop and evaluate computational methods to assist the interpretation of routine EEG and improve presurgical evaluation.\n","externalUrl":null,"permalink":"/members/jeanne-benoit/","section":"Membres","summary":"Dynamap","title":"Jeanne Benoit","type":"members"},{"content":"I am a PhD student jointly supervised by Christophe Bernard and Viktor Jirsa. Always having a passion for understanding complex systems, I decided to major in computational neuroscience during my final year of Master\u0026rsquo;s studies at Paris-Saclay University. Prior to this, I was trained in fundamental physics.\nMy PhD project centers around the study of low-dimensional structures, namely neural manifolds, that emerge from high-dimensional neural signals. It will be mostly based on sleep data in the first place, and I work towards a better understanding of the switch from one brain state to another.\n","externalUrl":null,"permalink":"/members/jiaxin-lyu/","section":"Membres","summary":"I am a PhD student jointly supervised by Christophe Bernard and Viktor Jirsa. Always having a passion for understanding complex systems, I decided to major in computational neuroscience during my final year of Master’s studies at Paris-Saclay University. Prior to this, I was trained in fundamental physics.","title":"Jiaxin Lyu","type":"members"},{"content":" Job Offer: Postdoctoral Researcher in Digital Twin Brain for Prediction of Longitudinal Trajectories in Alzheimer\u0026rsquo;s Disease # Chloé Duprat October 14, 2025 Institut de Neurosciences des Systèmes\n","externalUrl":null,"permalink":"/jobs/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Job Postings","type":"page"},{"content":" Job Offer: Postdoctoral Researcher in Digital Twin Brain for Prediction of Longitudinal Trajectories in Alzheimer\u0026rsquo;s Disease # Chloé Duprat October 14, 2025 Institut de Neurosciences des Systèmes\n","externalUrl":null,"permalink":"/opportunities/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Job Postings","type":"page"},{"content":"TNG\n","externalUrl":null,"permalink":"/members/joelle-micallef/","section":"Membres","summary":"TNG","title":"Joelle Micallef","type":"members"},{"content":"PhysioNet\nPrincipales étapes de carrière\n1978-1983 : Etudes de Médecine, Marseille\nInterne en Médecine : 1983-1989 : Médecine Interne, Rhumatologie, Neurologie\nThèse de Médecine : 1989\nAssistant Hospitalo-universitaire 1992 : Laboratoire d’Immunologie – Consultation Clinique / Service des maladies Neuromusculaires Pr G Serratrice.\nThèse de Sciences en Immunologie : 1992 : Centre d’Immunologie de Marseille-Luminy -supervision : Dr Ph Le Bouteiller.\nStage Post-doctoral (1992-1993) Max Plank Institute, Munich, Allemagne : Laboratoire de NeuroImmunologie du Pr H. Wekerle.\nHabilitation à diriger des Recherches en Immunologie : Septembre 2007\nChef d’équipe CNRS : “Interactions Neuroimmunes et pathologies du système nerveux”. NICN, puis CNR2M, UMR 7286. 2002-2017.\n2018 – 2021 : Institut de Neuroscience de la Timone (INT), UMR CNRS 7289 Equipe MirCOs, puis Canop depuis Janvier 2021.\n2021 – Institut des Neurosciences des Système, INS UMR 1106, Equipe C Bernard, Physionet\nActivités d’encadrement\nEncadrement de thèse de sciences (10 dont 2 en cours)\nEncadrement de Master 2 recherche : (38)\nMembre rapporteur de jury de thèse de Sciences (15) et d’HDR (6)\nCharges pédagogiques\nCharges pédagogiques : 250 h Faculté de Médecine, de Pharmacie, d’odontologie, de Sciences. Responsable de module d’enseignement :\n• DFGSM2 : tissus sanguins et système immunitaire\n• Module de Master 1 Immunologie Secteur Santé\n• Module de Master 1 Neurosciences (Co-habilité Sciences – Santé).\n• Module de Neuroimmunologie du diplôme inter-universitaire : Immunologie et Immunopathologie\nPrincipales responsabilités Universitaires\nMembre élu du CNU, section 47.03 : 2102-2017 – ré-élu en 2018\nMembre élu de la commission recherche AMU depuis 2017 – Membre du conseil Académique AMU.\nPrincipales activités hospitalières\nResponsable de 2 secteurs du laboratoire d’Immunologie AP-HM\n• Analyses immunochimiques des protéines sanguines, urinaires et du LCR\n• Biomarqueurs des pathologies auto-immunes, inflammatoires, neurodégénératives du système nerveux.\n","externalUrl":null,"permalink":"/members/jose-boucraut/","section":"Membres","summary":"PhysioNet","title":"José Boucraut","type":"members"},{"content":"Dynamap\nE-mail: julia.scholly@ap-hm.fr\n","externalUrl":null,"permalink":"/members/julia-scholly/","section":"Membres","summary":"Dynamap","title":"Julia Scholly","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/kabeer-abubakar/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Kabeer Abubakar","type":"members"},{"content":"Dynamap\nAs an engineer, I am in charge of the acquisition, pre-processing and processing of MEG, EEG and intracerebral EEG data. I also participate in the development of specific analysis tools for pre/post stimulation and the characterization of epileptic nodes and the impact of stimulation.\nMail: khoubeib.kanzari@univ-amu.fr\n","externalUrl":null,"permalink":"/members/khoubeib-kanzari/","section":"Membres","summary":"Dynamap","title":"Khoubeib Kanzari","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/laetitia-costa-de-beauregard/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Laëtitia Costa De Beauregard","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/laura-marin/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Laura Marin","type":"members"},{"content":"DCP\nAfter studying literature and completing a master\u0026rsquo;s degree in cognitive sciences at the University of Côte d\u0026rsquo;Azur, I am now pursuing a doctoral thesis under the supervision of Benjamin Morillon. My PhD project aims to understand the involvement of the motor system in speech perception, particularly in the processing of the temporal dynamics of the speech signal.\n","externalUrl":null,"permalink":"/members/laure-deyna/","section":"Membres","summary":"DCP","title":"Laure Deyna","type":"members"},{"content":"© INS 2018 All rights reserved.\nThis site is under the jurisdiction of French law, international copyright and intellectual property protection. Any reproduction, representation or alteration of this site or its contents, wholly or in part, is forbidden. Hypertext links to the Institut de Neurosciences des Systèmes web site may only be established with prior written consent from Institut de Neurosciences des Systèmes.\nInstitut de Neurosciences des Systèmes # Inserm UMR1106 Aix-Marseille Université Faculté de Médecine, 27, Boulevard Jean Moulin 13005 Marseille, France Tel +33(0) 4 91 29 98 14 Fax +33(0) 4 91 78 99 14\nCredits # Publication direction: Viktor Jirsa Website design, build and management: Tanya Brown Web hosting: Aix-Marseille Université\nConfidential or proprietary information # Information collected on this web site is used only to improve Institut de Neurosciences des Systèmes website. You are entitled to access, edit, modify or cancel any information given above. To do so, you can write to:\nInstitut de Neurosciences des Systèmes Inserm UMR1106 Aix-Marseille Université Faculté de Médecine, 27, Boulevard Jean Moulin 13005 Marseille, France\nMore information about legal aspects on CNIL, \u0026ldquo;Commission Nationale de l\u0026rsquo;Informatique et des Libertés\u0026rdquo;, visit their website.\n","externalUrl":null,"permalink":"/legal/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Legal — INS","type":"page"},{"content":"TNG\nPhone: +33 4 91 32 42 56\nAfter I obtained my master in neuroscience, I went directly into scientific project management, while simultaneously following management classes at Kedge Business School. I started working as Viktor Jirsa’s Scientific Project Manager in February 2019. I am dedicated to managing the international and national contracts of the INS and especially the TNG team. I am working in close contact with the researchers from the institute as well as from partnering intuitions, following-up on ongoing projects and collaborations. My greatest implication is my work as the WP1 manager within the Human Brain Project.\n","externalUrl":null,"permalink":"/members/lisa-otten/","section":"Membres","summary":"TNG","title":"Lisa Otten","type":"members"},{"content":"DynaMaP\nAfter graduating from a master\u0026rsquo;s degree in engineering specialized in acoustics and signal processing applied to music, I defended my PhD thesis in auditory neuroscience. My work aimed at a better understanding of cognitive processes involved in listening effort, using pupillometry and sclap electroencephalography (EEG). I then pursuied my research studies during a post-doc in Marseille at CRPN, focusing on the spatio-temporal dynamics of vestibular information processing, using EEG as well. I recently joined the INS within the Dynamap team to study the effect of thermocoagulation on stereo-EEG biomarkers of epileptogenicity and functional connectivity, in patients with refracotry epilepsy.\nContact: lou.SEROPIAN@univ-amu.fr\n","externalUrl":null,"permalink":"/members/lou-seropian/","section":"Membres","summary":"DynaMaP","title":"Lou Seropian","type":"members"},{"content":"DynaMaP\nPhD Student — As a psychiatry resident, my research focuses on the neural basis of emotional experience and its relevance to the treatment of mood disorders. After training in general psychiatry, electroconvulsive therapy, epileptology, and cognitive neurology at Timone and Sainte-Marguerite Hospitals in Marseille, I completed a Master 2 in Neurosciences at Aix-Marseille University alongside a research internship at the INS. My work combines clinical psychiatry with intracranial electrophysiology: I use SEEG-based direct electrical stimulation to map emotional responses in patients with drug-resistant epilepsy, with a particular focus on the anterior insula as a candidate target for neuromodulation in depression.\n","externalUrl":null,"permalink":"/members/lucas-arrighi/","section":"Membres","summary":"DynaMaP","title":"Lucas Arrighi","type":"members"},{"content":"DynaMaP\nAfter completing a Master’s degree in Computational Neuroscience and Neuroengineering at Paris-Saclay University, I joined the Dynamap team as a Cifre PhD student to work on the use of Optically Pumped Magnetometers (OPMs) for the characterization of epileptogenic networks in epileptic patients.\n","externalUrl":null,"permalink":"/members/lydia-stoutah/","section":"Membres","summary":"DynaMaP","title":"Lydia Stoutah","type":"members"},{"content":"I work on the derivation of human brain connectivity from signals recorded with SEEG electrodes implanted in brains of patients suffering from pharmaco-resistant epilepsy. The electrodes not only record, but also stimulate and tracking of the stimulus spread in the brain allows to infer connectivity pathways. This method, unlike diffusion-MRI connectivity mapping, allows to derive directionality of connections and latency of signal propagation. I integrate these information with structural connectivity to obtain a brain atlas of neuronal communication speeds along white matter tracts. In my other projects I use the enriched structural connectivity for resting state modelling, I work on an atlas of white matter maturation and on detection of responses to stimulation affected by epileptic pathologies.\nSince 2017 postdoctoral researcher working in Olivier David\u0026rsquo;s group on the F-TRACT project (https://f-tract.eu/) firstly in Grenoble and then in Marseille, France.\nMy Google Scholar profile\n","externalUrl":null,"permalink":"/members/maciej-jedynak/","section":"Membres","summary":"I work on the derivation of human brain connectivity from signals recorded with SEEG electrodes implanted in brains of patients suffering from pharmaco-resistant epilepsy. The electrodes not only record, but also stimulate and tracking of the stimulus spread in the brain allows to infer connectivity pathways. This method, unlike diffusion-MRI connectivity mapping, allows to derive directionality of connections and latency of signal propagation. I integrate these information with structural connectivity to obtain a brain atlas of neuronal communication speeds along white matter tracts. In my other projects I use the enriched structural connectivity for resting state modelling, I work on an atlas of white matter maturation and on detection of responses to stimulation affected by epileptic pathologies.","title":"Maciej Jedynak","type":"members"},{"content":"DCP\nAfter graduating in neurophysiology, I obtained a master’s degree in cognitive sciences from Paris University.\nNext, I moved to Switzerland to complete a PhD in neuroscience at Ecole Polytechnique Fédérale de Lausanne, under the supervision of Olaf Blanke , in collaboration with Christoph Michel from the Geneva University Hospital. During my PhD, I investigated visual motion perception and the multisensory aspects of embodiment using EEG brain mapping and clinical approaches.\nThanks to a prospective researcher fellowship from the Swiss National Science Foundation, I joined the laboratory of John Foxe and Sophie Molholm in New York. There, I investigated the role of neural oscillations in multisensory processes using intracranial and surface recording in humans. Next, I work with Fred Lado, Ashesh Mehta and Charlie Schroeder’s teams to develop multimodal tools for human intracranial investigations.\nBack in France, a Marie Sklodowska-Curie Individual Fellowship from the European Commission allowed me to join the CerCo laboratory (CNRS, UMR5549) to pursue my investigations on multisensory processing, and especially the interplay with decision making.\nCurrently appointed at the Institute of Systems Neuroscience (Inserm, U1106) at Aix-Marseille University, I joined the DCP team to investigate the link between cognitive process and brain network dynamic using intracranial recording in human.\nIn addition to my research work, I promote the open and slow science frameworks to support research responsibility and ecological sobriety. I am an active member of the AtÉcoPol d’Aix-Marseille, a collective of scientists communicating about environmental issues and acting at redirecting the trajectory of our society from a systemic perspective.\nhttps://orcid.org/0000-0001-6358-4734\n","externalUrl":null,"permalink":"/members/manuel-mercier/","section":"Membres","summary":"DCP","title":"Manuel Mercier","type":"members"},{"content":"TNG\nIn 1989 I have finished my master 2 in theoretical physics (plasmas physics) from the University of Grenoble and I have integrated the famous military school of Saint Cyr-Coëtquidan and spent 8 months as officer instructor. I completed my thesis the in 1994 with the title: ‘experimental study of a multipolar plasma discharge’. From 1994-1995 I went to Holland, where I was a researcher on plasma jets and tomography and in 1995 I was recruited to be a full teacher and started studying surface spectroscopy (HREELS) and designing an Helicon plasma discharge (RF discharges) and Langmuir probes, studies of anodic and cathodic sheath physics, and I discovered the creation on negative ions on a carbon surface facing hydrogen plasma. I also collaborated with a company, Ion Beam Services (IBS) and we built a new plasma implanter. All these works allow to pass the 6 January 2009 : “Habilitation à Diriger des Recherches” HDR , University of Provence « Plasmas, Surfaces and the interaction Plasma- surface. ». During all this period I was also Supervisor for CIES 2002-2011 to perform neuro-linguistic programming and didactic works for professional methods to improve education. My Teaching activities (AMU), are covering fields in electronic, applied physics , relativity , sensors physics, statistical physics, radioactivity, plasmas physics, optics, electrostatics, magneto-static, practical teaching for epilepsy and computational neuroscience (Licence1 to M2 biology and Nano- physics).\nSince 2012 I am member of the team \u0026ldquo;Theoretical Neurosciences Group\u0026rdquo; here at INS, where my work if focused on measuring TMS-EEG at rest for healthy subjects in order to compare with modeling of epileptic patient and resting state patient with The Virtual Brain and I perform multi-signal analysis with software like EEGlab, Anywave, Brainstorm, Fieldtrip, Matlab and python programming.\n","externalUrl":null,"permalink":"/members/marcel-carrere/","section":"Membres","summary":"TNG","title":"Marcel Carrere","type":"members"},{"content":"PhysioNet\nBorn and bred in Rome, I studied Neuroscience in London and Paris where I pursued with a PhD supervised by Thérèse Jay and Sidney Wiener and then with a postdoc with Michaël Zugaro.\nI am ultimately interested in the dynamics allowing the exchange of information between brain areas, namely how the information encoded in one neural structure is able to modulate the encoding in another area (and the other way around), and how these interactions orchestrate perception, learning, and behavior. To do so, my primary experimental approach is to perform high-density recordings of individual neurons simultaneously in multiple brain sites of freely behaving rats and then use data mining and analysis to study neural population dynamics.\n","externalUrl":null,"permalink":"/members/marco-pompili/","section":"Membres","summary":"PhysioNet","title":"Marco Pompili","type":"members"},{"content":"Dynamap\nAfter obtaining a Master Degree in Biomedical Engineering at the University of Rome \u0026ldquo;La Sapienza\u0026rdquo;, where I discovered my interest for biomedical signal processing and neuroscience, I\u0026rsquo;ve joined the Dynamap team as a research engineer to work on the EPINOV project.\n","externalUrl":null,"permalink":"/members/maria-fratello/","section":"Membres","summary":"Dynamap","title":"Maria Fratello","type":"members"},{"content":"DCAP\nThesis title: Temporal dynamics of natural sounds representations in human brain: acoustic, semantic and intermediate representations\nMy thesis project is part of a heavily collaborative project involving Giordano and Schön (Aix-Marseille University) and Formisano (Maastricht University). The aim of this collaborative project is to gain a better understanding of the neural dynamics of the process of transforming the acoustic representation of a sound (the representation of the sound\u0026rsquo;s physical characteristics) into its semantic representation (e.g. the representation of the source of the sound: what/who, how and where; Giordano et al., (2022)). We know that auditory processing consists firstly of acoustic analyses of the sound, in particular frequency analyses at the level of the cochlea followed by spectro-temporal modulations analysis at the level of the primary auditory cortex (A1). However, the emergence of semantic representations of sound is still under debate. They appear to be already present in the superior temporal gyrus (STG) and ventrolateral prefrontal cortex (VLPFC). They then integrate a widespread neural network associated with an amodal semantic representation of sound (Binder, 2011). In order to clarify the spatiotemporal dynamics of these acoustic and semantic representations of sound, several neuroimaging techniques are being used in this collaborative project: magnetoencephalography (MEG) for its good temporal resolution (as part of my thesis project), functional magnetic resonance imaging (fMRI) for its good spatial resolution and intracranial electroencephalography (iEEG) for its good spatio-temporal resolution and the quality of the signal obtained (much higher than that obtained by indirect measurement). My thesis project therefore focuses on the temporal dynamics of acoustic and semantic representations of sounds. The general objective is to establish spatiotemporal maps of the acoustic and semantic representations of sounds in the brain in order to identify the temporal dynamics of the transformation of the acoustic representation of the sound into a semantic representation, the brain regions involved and to study the general process of object discrimination (which semantic representations are used). To this end, we are comparing acoustic and semantic representations derived from computational models with MEG brain data, over time. A representational similarity analysis (RSA) between the sounds is first performed for each type of representation (acoustic, semantic or cerebral), then different linear regressions of the cerebral response distances are performed based on the acoustic or semantic distances from the models.\n","externalUrl":null,"permalink":"/members/marie-plegat/","section":"Membres","summary":"DCAP","title":"Marie Plegat","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/marmaduke-woodman/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Marmaduke Woodman","type":"members"},{"content":"PhysioNet\n","externalUrl":null,"permalink":"/members/mathilde-nordlund/","section":"Membres","summary":"PhysioNet","title":"Mathilde Nordlund","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/matthieu-aguilera/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Matthieu Aguilera","type":"members"},{"content":"DCP\n","externalUrl":null,"permalink":"/members/maude-denis/","section":"Membres","summary":"DCP","title":"Maude Denis","type":"members"},{"content":"Viktor JIRSA | Director of INS Christophe BERNARD | DR Inserm Benjamin MORILLON | DR Inserm (HDR) | D-CAP Team Lead Aurélie BIDET-CAULET | CR Inserm (HDR) Daniele SCHÖN | DR CNRS (HDR) Agnes TREBUCHON | PU-PH (HDR) Fabrice BARTOLOMEI | PU-PH (HDR) Jean Michel BADIER | IR AMU Christian BENAR | DR Inserm Olivier BLIN | HDR Mira DIDIC | PH (HDR) Olivier FELICIAN | PU-PH (HDR) Driss BOUDDSAOUD | DR CNRS (HDR) Sylvie BONIN-GUILLAUME | PU-PH (HDR) Mireille BONNARD | DR CNRS (HDR) Francesca Bonini | MCU-PH Stéphane ROMAN | PH Manuel MERCIER | IR INSERM Sophie CHEN | IE Inserm Jeanne BENOIT | MD, PhD Student Eya BOURGUIBA | Project Manager Véronique SABADELL | Speech therapist Flavius BRATU | MD, PhD Student Marcel CARRERE | MCU Romain CARRON | MCU-PH (HDR) Zakia Chidhouri | Engineer Catherine CASSE-PERROT | Neuropsychologue Bruno COLOMBET | AI AMU Olivier DAVID | DR Inserm (HDR) Damien DEPANNEMAEKER Beatrice DESNOUS | MD, PhD Aitakin EZZATI | PhD student (sup. C Bernard, V Jirsa) Borana DOLLOMAJA | Engineer Maria Fratello | PhD Student Elisabeth FRAUGER | PH Florence GAILLARD-BIGOT | Neuropsychiatre Gaetan GENTILE | MCU Antoine GHESTEM | IE AMU Raphaël GUEX | Postdoc Romain GUILHAUMOU | PH Meysam HASHEMI | Postdoc Anton IVANOV | IR Inserm Maciej JEDYNAK | Postdoc Elisabeth JOUVE | Ingénieur APHM Khoubeib KANZARI | Engineer Farid KHELOUFI | PH Stanislas LAGARDE | MCU-PH, MD PhD Isabelle LAMBERT | MD, PhD Victor LOPEZ-MADRONA | Postdoc Samuel MEDINA | Engineer Joelle MICALLEF | PU-PH (HDR) Lisa Otten | Project Manager Spase PETKOSKI | Postdoc Francesca PIZZO | MD, PhD Hugo QUENON | Engineer Pascale QUILICHINI | CR Inserm Team Leader Roland RIZOULIERE | MCU Didier SCAVARDA | PU-PH (HDR) Julia SCHOLLY | MD, PhD Capucine RODET | PhD Student Lou SEROPIAN | Postdoc Sara SIMULA | Postdoc (sup. M Pompili) Pierpaolo SORRENTINO | Postdoc Huifang WANG | IR2 Inserm Marmaduke WOODMAN | IR2 AMU Xavier ZENDJIDJIAN | PH Jean-Didier Lemarechal | Postdoc Jan Paul Triebkorn | Doctorant Aurélie GRANDJEAN | Postdoc Chiara MAZZOCCONI | Postdoc Jacques PESNOT LEROUSSEAU | Postdoc Pierre Hieu GUILLEMINOT | Postdoc Paul LALANDE-ROBERT | PhD Student Anne MATHIEU | PhD Student Emma BERTHAULT | PhD Student Clément SAUVAGE | PhD Student Marco POMPILI | Junior Research Fellow Bissera IVANOVA | PhD Student José BOUCRAUT | MCU CE-PH Nariman KIANI | Postdoc (Sup. C Bernard) Jiaxin LYU | PhD student (Sup. C Bernard, V Jirsa) Kabeer ABUBAKAR | PhD student (Sup. C Bernard \u0026amp; A Ivanov) Sylvie Thirion | MCU AMU Marie PLEGAT | PhD Student Laure DEYNA | PhD Student Hiroyoshi YAMASAKI | PhD Student Maude DENIS | PhD Student Sabrina RODRIGUES | PhD Student Caroline MODENA | ADT AMU Audrey Moreau IE Inserm Maria Benkasmi AI Inserm Mathilde NORDLUND | IR AMU Anthony BOYER | Postdoc Sofia AVALOS-ALAIS | PhD student Pia VAYSSIERE | PhD student Gabriel MAKDAH | PhD student (Sup. M Pompili, P Quilichini) Pietro BOZZO | PhD student (Sup. P Quilichini, M Pompili) Cristiana PINHEIRO | Postdoc Francesco BORRA | Postdoc Giovanni BELLONI | PhD Student Charles-Edouard QUERLIER | Master Student (Réseaux et télécommunication) Laura MARIN | M2 Student (sup. P Quilichini, M Pompili) Nataly MILAN | PhD student (sup. P Quilichini, C Bernard) Tessa CANCIO-PASTOR | PhD Student Mia BERTOVIC | PhD Student Guillaume BRUNO | Intern Centrale-Supélec Paris Laëtitia COSTA DE BEAUREGARD | Intern Centrale-Supélec Paris Matthieu AGUILERA | Postdoc (sup. P Quilichini, C Bernard) Lucas ARRIGHI | PhD Student Lydia STOUTAH | PhD Student Petra CIPOLLA | Engineer Camille MAZZARA | Postdoc\nALUMNI # Patrick CHAUVEL Catherine Liegeois CHAUVEL Matteo DEMURU | Postdoc Christos PAPAGEORGAKIS Nicolas ROEHRI Maya ALLOUCHE | IR AMU Sora AN | Postdoc Anastasia EGHIAIAN-LOMAN | IR CDD AMU Ana Maria FERNANDEZ-VINCENT | Postdoc PRIYA GHUMATKAR | Postdoc Patrick MARQUIS | IE Inserm Alexia FASOLA | Doctorant Lorenzo Ferri | MD-Intern Francesca MELOZZI Aurélie PONZ | IR CDD AMU Romanos POULKOURAS | Doctorant Jennyfer SCAPULA Irene YUJNOVSKY | Project Manager Willemiek J.E.M. ZWEIPHENNING | MD-PhD student Kenza HOUSSAINI | Postdoctoral Fellow Diego Martin LOMBARDO | Doctorant Thomas DOUBLET | Postdoc Djouya (Mohammad) ARBABYAZD | Doctorant Emma ACERBO | PhD Student David ALEXANDER | Postdoc Veronique AYALA | TN Inserm Mikhael AZILINON Abhirup BANDYOPADHYAY | Postdoc Swati BANERJEE | Postdoc Wesley CLAWSON | Doctorant Daniele DAINI | Doctorant Emmanuel DAUCE | MCU (HDR) Matteo DEMURU | Postdoc Christian GESTREAU | MCU (HDR) Jeremy GIROUD | Doctorant Hussein HAMDI | Doctorant Loig KERGOAT Mario LAVANGA | Postdoc Adam LI Galyna MALIEIEVA | Postdoctoral Fellow Florian MISSEY | PhD Student Mitsuyoshi NAKATANI | PhD Student Christos PAPAGEORGAKIS | Postdoc Nicola PEDRESCHI | Doctorant Claire PELOFI Noémie te Rietmolen | Postdoc MARC REY | MCU-PH (HDR) Christophe RODO | Nicolas ROEHRI | Postdoc Evgeniia RUSINA | Doctorant Sawssan SAFIEDDINE | Doctorant Maria Luisa SAGGIO | Doctorant Aileen McGONIGAL | PH Sonia TIMOURIAN | ADT AMU Vineet TIRUVADI | Anirudh Nihalani VATTIKONDA | Doctorant Bahar Hazal YALCINKAYA | Postdoc Yuri ZYLBERTER | Emeritus DR2 Inserm Matthias DIPPER-WAWRA | PostDoc Jayant Jha | Postdoc Carmela CALABRESE | Postdoc Gian Marco DUMA | Postdoc Céline HIDALGO | PostDoc Daniela MORANGE | MD, Doctorant Arnaud ZALTA | PhD Student Nadège MARIN | Engineer Demian BATTAGLIA | CR CNRS Sophie BENITEZ STULZ | PhD student Jan FOUSEK | Postdoc Lionel KUSCH | Doctorant Giovanni RABUFFO| Postdoc Viktor SIP | Postdoc Conchetta TAVERNA | ADT AMU Adam WILLIAMSON | CR Inserm Ouafae ARAB | IE AMU HIBA SHEHEITLI | Postdoc Armelle LOKOSSOU | Postdoc Rémy CORNUEJOLS | PhD student Monique ESCALPEZ | DR2 Inserm Maeva FERRARIS | PostDoc Piotr BREGESTOVSKI | Emeritus DR Inserm Yann ROCHE-MARTELET | Intern Raphaël NUNES DA SILVA | Intern Hugo DEGENEVE | Intern Christian Ferreyra | Research Engineer Maëva Daoud | PhD Student Elodie Garnier | Research Engineer Velmurugan Jayabal | PostDoc Aude Jegou | Research Engineer Marie Robert | Intern Isaih Mohamed | PhD Student Camille BESNAINOU | Research Engineer Nicolas Hemmer | Research Engineer Daria PONOMAREVA | PhD student Corentin LASNE | Intern Myriam AZZARELLI | PhD Student Richard BOYCE | Postdoc (sup. C Bernard) Nathan MIMOUNI | Intern (sup M Pompili) Shunzuke KAJIWARA | Postdoc (Sup. C Bernard)\n","externalUrl":null,"permalink":"/members/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Membres","type":"page"},{"content":"I have studied physics, soft condensed matter in IASBS, Iran. Then, I received my Ph.D. in computer science from INRIA CR Nancy Grand Est. My doctoral thesis, under the direction of Dr. Axel Hutt, aimed to investigate the mechanisms underlying the observed specific changes in EEG patterns during propofol-induced anesthesia. I have extensive experience working with neural models at single neuron and neural population levels, in both numerically and analytically approaches. I have a keen interest in Bayesian inference and parameter estimation algorithms. Currently, I am a postdoctoral researcher with TNG at INS Marseille, under the direction of Dr. Viktor Jirsa. My aim is to infer the dynamics of personalized large-scale brain network models using Bayesian framework.\n","externalUrl":null,"permalink":"/members/meysam-hashemi/","section":"Membres","summary":"I have studied physics, soft condensed matter in IASBS, Iran. Then, I received my Ph.D. in computer science from INRIA CR Nancy Grand Est. My doctoral thesis, under the direction of Dr. Axel Hutt, aimed to investigate the mechanisms underlying the observed specific changes in EEG patterns during propofol-induced anesthesia. I have extensive experience working with neural models at single neuron and neural population levels, in both numerically and analytically approaches. I have a keen interest in Bayesian inference and parameter estimation algorithms. Currently, I am a postdoctoral researcher with TNG at INS Marseille, under the direction of Dr. Viktor Jirsa. My aim is to infer the dynamics of personalized large-scale brain network models using Bayesian framework.","title":"Meysam Hashemi","type":"members"},{"content":"D-CAP\nI began my academic journey in psychology, studying attention through multiple object tracking, and then completed a Master’s in Cognitive Neuroscience focused on computational modelling of musical surprisal. My PhD in auditory neuroscience explores hedonic responses to natural sounds, aiming to understand both typical experiences of pleasantness and atypical sensitivities, such as misophonia. Using EEG, MEG, psychophysics, physiology, and behavioural methods, I combine computational and experimental approaches to investigate how the brain encodes the emotional impact of sound.\n","externalUrl":null,"permalink":"/members/mia-bertovic/","section":"Membres","summary":"D-CAP","title":"Mia Bertovic","type":"members"},{"content":"DCP\n","externalUrl":null,"permalink":"/members/mira-didic/","section":"Membres","summary":"DCP","title":"Mira Didic","type":"members"},{"content":"Phone: 33 (0)4 91 32 42 54\nMB started her research in behavioral sciences, investigating how human gait (as all the sensori-motor automatisms -respiration, mastication, etc) can be modulated intentionally. This allows adaptation of these vital functions to the subject\u0026rsquo;s will, given the environmental constraints and the dynamical properties of the effector system. She got her PhD in 1991 in the laboratory \u0026ldquo;Cognition and Movement\u0026rdquo; (head: J. Pailhous) and got a permanent researcher position at CNRS in 1994.\nThen, she developed an expertise in non-invasive techniques allowing the exploration of brain activation (fMRI, EEG, TMS) combined with behavioural data, in healthy human. 1998 to 2004, she led the team \u0026ldquo;Cerebral substrates of voluntary movement\u0026rdquo; in the laboratory \u0026ldquo;Movement and Perception (head: J. Pailhous). 2004 to 2011, she was the head of a team \u0026ldquo;Intention and action control\u0026rdquo; at the \u0026ldquo;Institut de Neurosciences Cognitives de la Méditerranée\u0026rdquo; (head: D. Boussaoud).\nSince 2005, she is the scientific leader of an original platform (open to the community) allowing cortical focal stimulation (using MRI-guided Transcranial Magnetic Stimulation – TMS) combined with simultaneous recording of brain activation (using EEG) in humans. This neuronavigated TMS offers the possibility to induce a well-localized central perturbation of brain dynamics in healthy human subjects, and to on-line measure its direct effects on cortical activation. Moreover, TMS can be triggered depending on the immediate dynamic state of the brain, based on online processing the EEG. From the response of the brain to this stimulation, one can discover many properties of brain activation and try to interfere with them in return. For 2012, she joined the \u0026ldquo;Institut de Neurosciences des Systèmes, and she developed several fruitful collaborations with combined neuronavigated TMS and EEG with researchers inside and outside the laboratory on motor control, resting states, language, consciousness of our own body parts.\n","externalUrl":null,"permalink":"/members/mireille-bonnard/","section":"Membres","summary":"Phone: 33 (0)4 91 32 42 54","title":"Mireille Bonnard","type":"members"},{"content":"I started my journey in neurosciences from the University of Calgary. My fascination with research started when I embarked on completing my honors thesis on the topic of Brain-Gut-Microbiota axis. After a year-long pause in Sweden as an exchange student, I began master’s degree in the University of Bonn, Germany. There, I developed a sense of curiosity regarding the pathologies of synaptic transmission, especially in the context of stroke.\nNow, I work on electrophysiology and astrocyte neurobiology in the context of epilepsy. The topic of my PhD thesis concerns K+ clearance and metabolic processes in astrocytes before the onset of seizures.\n","externalUrl":null,"permalink":"/members/nariman-kiani/","section":"Membres","summary":"I started my journey in neurosciences from the University of Calgary. My fascination with research started when I embarked on completing my honors thesis on the topic of Brain-Gut-Microbiota axis. After a year-long pause in Sweden as an exchange student, I began master’s degree in the University of Bonn, Germany. There, I developed a sense of curiosity regarding the pathologies of synaptic transmission, especially in the context of stroke.","title":"Nariman Kiani","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/nataly-milan/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Nataly Milan","type":"members"},{"content":"TNG\nHead of the Clinical Pharmacology \u0026amp; Pharmacovigilance Department\nOlivier BLIN (MD, PhD, MBA), is Professor of Pharmacology at Aix-Marseille University, certified in Neurology, Psychiatry and Medical Biology. He owns a PhD in Human Biology as well as a MBA from Ecole Centrale Paris. He is currently Head of the Clinical Pharmacology \u0026amp; Pharmacovigilance Department, Marseille University Hospital (Ap-Hm), member of UMR AMU-INSERM 1106, and coordinator of the University Hospital Federation DHUNE, COEN center on neurodegenerative disorders and aging (www.dhune.org). At the national level, he is a Member of the Working Group French National Plan for Rare Diseases, Member of the National Steering Committee French National Plan for Neurodegenerative Diseases and of the scientific committee of CNS ITMO Aviesan. He also is Vice President of the scientific council of CSFRS (Ecole Militaire, Paris).\n","externalUrl":null,"permalink":"/members/olivier-blin/","section":"Membres","summary":"TNG","title":"Olivier Blin","type":"members"},{"content":"OD graduated in applied physics at Ecole Normale Supérieure de Cachan, and obtained a PhD from Université Paris Sud in signal processing applied to human neurophysiology at CNRS / La Salpêtrière Hospital. He did a post-doc at University College London where he developed a highly cited method for inferring properties of neuronal populations underlying brain oscillations (Dynamic Causal Modelling for MEG/EEG). In 2005, he obtained a permanent researcher position to coordinate an EEG/fMRI program in humans and rodents at the INSERM Grenoble Institute of Neuroscience, France. He is now Inserm Director of Research and has been leading a research group focused on preclinical and clinical neurophysiology in refractory neurological and psychiatric disorders. The main topic of his current research is to understand the effects of brain stimulation on the organization of functional brain networks. He has published more than 180 articles in international peer-reviewed journals including several highly cited articles in human neurophysiology and epilepsy. He holds 1 patent and developed 3 software solutions distributed worldwide. He has participated in more than 60 competitive research grants, e.g. was PI of 1 ERC-CoG (ended in 2019), 1 ERC-PoC (ended in 2019) and was co-leading some medical applications of the European Flagship Human Brain Project (ended in 2023). He has been involved as scientist in more than 18 clinical trials, and as expert in many evaluation committees, e.g. European Commission, ANR (past president of the panel “Integrative and Cognitive Neuroscience”), NSF for CRCNS call.\n","externalUrl":null,"permalink":"/members/olivier-david/","section":"Membres","summary":"OD graduated in applied physics at Ecole Normale Supérieure de Cachan, and obtained a PhD from Université Paris Sud in signal processing applied to human neurophysiology at CNRS / La Salpêtrière Hospital. He did a post-doc at University College London where he developed a highly cited method for inferring properties of neuronal populations underlying brain oscillations (Dynamic Causal Modelling for MEG/EEG). In 2005, he obtained a permanent researcher position to coordinate an EEG/fMRI program in humans and rodents at the INSERM Grenoble Institute of Neuroscience, France. He is now Inserm Director of Research and has been leading a research group focused on preclinical and clinical neurophysiology in refractory neurological and psychiatric disorders. The main topic of his current research is to understand the effects of brain stimulation on the organization of functional brain networks. He has published more than 180 articles in international peer-reviewed journals including several highly cited articles in human neurophysiology and epilepsy. He holds 1 patent and developed 3 software solutions distributed worldwide. He has participated in more than 60 competitive research grants, e.g. was PI of 1 ERC-CoG (ended in 2019), 1 ERC-PoC (ended in 2019) and was co-leading some medical applications of the European Flagship Human Brain Project (ended in 2023). He has been involved as scientist in more than 18 clinical trials, and as expert in many evaluation committees, e.g. European Commission, ANR (past president of the panel “Integrative and Cognitive Neuroscience”), NSF for CRCNS call.","title":"Olivier David","type":"members"},{"content":"DCP\n","externalUrl":null,"permalink":"/members/olivier-felician/","section":"Membres","summary":"DCP","title":"Olivier Felician","type":"members"},{"content":"Here we showcase the collection of INS collaborations, partners and large-scale projects. Our research alliances spans across various institutes in Marseille, traverse France and spread out internationally and enable us to push boundaries of scientific exploration. We are proud to be part of each of these consortiums and are always open to building new and meaningful connections.\nCOLLABORATIONS # Institute Of Language, Communication And The Brain | ILCB # Brain And Language Research Institute | BLRI # Several INS researchers from both the DCP and the TNG teams are active members of the Institute for Language and Brain Communication (ILCB). The ILCB – extending and continuing the previous Brain and Language Research Institute (BLRI) – is a state funded Convergence Institute, federating multi-disciplinary teams across several multi-disciplinary labs at Aix-Marseille University and Avignon University. To understand the way that language functions and to model it, ILCB brings together experts in linguistics, neuroscience, psychology, medicine and computer science working on cross-cutting questions and maintaining open research platforms. ILCB also supports education by offering doctoral fellowships and by putting in place new forms of training.\nNEUROSCHOOL | AMU # INS is a member of NeuroSchool at Aix-Marseille Université. More specifically, INS hosts AMU Master\u0026rsquo;s and PhD neuroscience students within the labs of the various research groups, determined by a students specific area of interest. By embedding AMU neuroscience students within a rich research setting during their formative educational experience, said students receive exemplary exposure to the fundamentals of scientific research directly from experts in their respective fields. INS researchers are actively involved in NeuroSchool training events, such as the courses in Computational Neuroscience.\nPARTNERSHIPS # HUMAN BRAIN PROJECT # The Human Brain Project (HBP) is a 10-year European Flagship project, aiming at a comprehensive understanding of the human brain. To achieve this, the HBP combines excellent neuroscience research with the development of a joint platform for research and brain-inspired technology development. The HBP is following a unique, multi-disciplinary approach to accelerate brain research, brain medicine and brain-inspired technology. The HBP flagships represent a new partnering model for visionary, long-term European cooperative research and with the leadership of INS\u0026rsquo;s director, Dr Viktor Jirsa, an official partnership with HBP has been realized.\nCLEVELAND CLINIC # INS is an international associated partner of Epi-Surge with Cleveland Clinic in Ohio USA. The goal of the Episurge project is to provide clinicians with novel, complementary tools that will increase surgery success and minimize invasiveness for the treatment of focal drug resistant epilepsy (DRE). Our common solution towards a better management of DRE is a bioinformatic approach using personalized brain models, derived from each patient\u0026rsquo;s own anatomy using The Virtual Brain.\nLearn more\nBAYCREST HOSPITAL # As part of the Brain Network Recovery Group (Brain NRG), lead by Dr. Randy McIntosh at Baycrest and supported by the James S McDonnell Foundation, Dr Viktor Jirsa together co-founded The Virtual Brain (TVB). As a part of this consortium, our ongoing partnership with Baycrest has been pivotal in ensuring the success of this multimillion dollar, multinational project has been realized and continues to advance the understanding of large-scale brain network dynamics.\nCHARITÉ UNIVERSITÄTSMEDIZIN BERLIN # The ongoing partnership with Charité Universitatmedizin Berlin, specifically Dr Petra Ritter (co-founder of TVB), has been incremental in the ongoing success of The Virtual Brain platform. Here, we have worked together to build the first brain modelling platform that captures the personalized features one\u0026rsquo;s own brain structure and function and simulates it in a scientifically valid way.\nINTERNATIONAL NEUROINFORMATICS COORDINATING FACILITY # INS is a member of INCF (International Neuroinformatics Coordinating Facility), an international non-profit organization for open and FAIR neuroscience. The mission of INCF is to develop, evaluate, and endorse standards and best practices that embrace the principles of Open, FAIR, and Citable neuroscience. INCF also provides training on how standards and best practices facilitate reproducibility and enables the publishing of the entirety of research output, including data and code.\nLARGE SCALE PROJECTS # EPINOV # Improving EPilepsy surgery management and progNOsis using Virtual brain technology\nThousands of patients with drug resistant focal epilepsy (DRE) undergo resective brain surgery with the aim of achieving seizure freedom. Despite technical advances, the success rate of epilepsy surgery in terms of seizure freedom has not greatly improved, remaining at around 50%. Epilepsy surgical failure can be due to the non-resection or insufficient modulation of the important nodes and pathways that characterize the epileptogenic network. For any candidate for epilepsy surgery, the critical factor in deciding upon the treatment strategy is the correct estimation of surgery outcome. No reliable procedure currently exists to combine the various prognostic factors for a given patient. This leads to great uncertainty on an individual scale in predicting the effects of surgery. The aim of this project is to guide surgical strategies to improve epilepsy surgical prognosis by a novel approach of large-scale brain modeling based on individual epileptic patient data.\nLearn more\n","externalUrl":null,"permalink":"/our-network/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Our Network — INS","type":"page"},{"content":"Phone: +334 91 32 42 31\nResearch Gate page | Google Scholar page\nI am the \u0026ldquo;Dynamics of Neuronal Networks and Memory” group leader. We currently investigate the interactions between the temporal lobe (hippocampus and parahippocampal cortices), the thalamus (Nucleus Reuniens) and prefrontal cortex in the context of memory consolidation in physiological and pathological conditions. Our goal is to map the inner dynamics, both at the individual neuronal and functional connectivity levels, among these networks in order to decipher the mechanisms supporting the transfer of information for its long-term storage and how these processes are altered in pathology.\n","externalUrl":null,"permalink":"/members/pascale-quilichini/","section":"Membres","summary":"Phone: +334 91 32 42 31","title":"Pascale Quilichini","type":"members"},{"content":"DCP\n","externalUrl":null,"permalink":"/members/paul-lalande-robert/","section":"Membres","summary":"DCP","title":"Paul Lalande-Robert","type":"members"},{"content":"DynaMaP\nI graduated in Biomedical Engineering from Politecnico di Milano and KU Leuven specializing in biomedical data processing. For my master thesis, I focused on the analysis of diffusion MRI data. I am currently working at Dynamap on the new OPM-MEG system.\n","externalUrl":null,"permalink":"/members/petra-cipolla/","section":"Membres","summary":"DynaMaP","title":"Petra Cipolla","type":"members"},{"content":"NeuroStim\n","externalUrl":null,"permalink":"/members/pia-vayssiere/","section":"Membres","summary":"NeuroStim","title":"Pia Vayssiere","type":"members"},{"content":"TNG\nA medical doctor and neurologist by training, I hold a Ph. D. in Engineering. My main area of expertise is the study of novel methods to describe the global changes that neurodegenerative diseases induce in the brain. To tackle this issue, I base my analyses mainly on magnetoencephalography. I have contributed to applying frameworks such as the study of synchronization, dynamical systems and network topology to brain-derived data. I am a co-founder of the MEG facility in Naples, where I curated the setting up of the laboratory as well as the acquisitions of various cohorts of patients. I am currently involved in the attempt to adjust models in order to improve predictions of the large-scale behavior of the brain. All in all, I am still moved by the desire to contribute to unraveling and measuring the properties that make the human brain what it is.\n","externalUrl":null,"permalink":"/members/pierpaolo-sorrentino/","section":"Membres","summary":"TNG","title":"Pierpaolo Sorrentino","type":"members"},{"content":"DCAP\nhttps://scholar.google.com/citations?user=TFq_NtkAAAAJ\u0026hl=fr\nhttps://phg17.github.io/\n","externalUrl":null,"permalink":"/members/pierre-hieu-guilleminot/","section":"Membres","summary":"DCAP","title":"Pierre Hieu Guilleminot","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/pietro-bozzo/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Pietro Bozzo","type":"members"},{"content":"INS is a well equipped, state-of-the-art research facility strategically embedded within France\u0026rsquo;s largest hospital\nHIGH PERFORMANCE CLUSTER # The Virtual Brain (TVB) is an open source neuroinformatics platform, which combines a large-scale brain network model and neuroimaging modality (s/EEG/MEG \u0026amp; fMRI) simulator, optimized for realistic brain connectivity \u0026amp; geometry and neural mass models, with a framework for constructing, visualizing and analyzing brain network models in a collaborative, project oriented user interface, accessible via web browser. General purpose use is supported via SSH or Jupyter, in addition to support for software development with an onsite GitLab instance. This platform is backed by dedicated high-performance computing (HPC) hardware, complemented by clustered nodes for virtual machines running public-facing web services, located in the medical faculty of the La Timone campus. Installed in September 2011, the cluster dedicates 95 TB high-performance storage, 2.5TB RAM, 400 Xeon cores \u0026amp; 8 NVidia GPUs to both local users in modeling collaborations and worldwide users of the TVB platform.\nUsers of the TVB platform can find additional information on the TVB cluster wiki or contacting a member of the staff: Huifang Wang (IR) or Marmaduke Woodman (IR)\nMEG # Magnetoencephalography (MEG) is the recording of the brain\u0026rsquo;s magnetic activity. This activity is the counterparts of the electrical activity that originate from the brain, recorded by EEG. These techniques are the only ones that are directly related to the neural activity and have enough time resolution to track brain activity. One of the great advantages of the MEG over EEG is the very small effect of the geometry of the different media of the head, especially the skull, on the recorded signals.\nOur MEG laboratory uses a 248 magnetometers MEG system (4D Neuroimaging magnes 3600), installed within the Neurophysiology department of La Timone hospital (Head: F Bartolomei). The system was co-financed by: Conseil Régional PACA, Conseil Général 13, Conseil Général 06, Marseille Provence Métropole, INSERM, CNRS, INRIA. The lab is equipped with stimulation apparatus, including video projection and Stax calibrated system for auditory stimulation. It belongs to the Aix-Marseille Université and is accessible to all teams involved in fundamental and clinical brain research. The MEG is collaborating in particular with the Epilepsy clinical group of AP-HM and with the Institute for Language Communication and the Brain.\nThe research team of the MEG lab is specialized in confronting results of source localization to intracerebral EEG and in designing and optimizing signal processing methods for multimodal functional investigation of human cerebral activity (pathological and physiological) (see Dynamap publications). For all publications of the MEG lab, see MEG publications.\nMEG Lab team: Jean-Michel Badier (technical director); Christian Bénar (scientific director); Bruno Colombet (software developer).\nThe MEG laboratory has developed a software called Anywave for the visualisation and analysis of electrophysiological data: MEG, EEG, SEEG (developer: Bruno Colombet), available there. The guiding principles are modularity and cross-platform portability.\nTMS | EEG-TMS # Transcranial magnetic stimulation (TMS) is a powerful tool that can directly, both temporarily and focally, perturb brain dynamics in healthy human subjects engaged in different tasks. In the last decades, this technique has become much more powerful due to its combination with individual MRI, allowing to precisely guide TMS according to individual anatomy. Recently, the combined use of stereotactic TMS with EEG further expanded the scope of TMS towards focal studies of living human brain\u0026rsquo;s reactivity and connectivity. From this reaction to TMS, many things can be discovered concerning the dynamical state of a brain, and abnormalities in brain reactivity and connectivity can be identified. Finally, more recently, we triggered TMS according to the dynamic state of the brain via online continuous processing the alpha cortical rhythm.\nAt INS, we have two Magstim 200 TMS stimulators (Magstim, Whitland, UK), potentially coupled with a bi-stim module, coplanar figure-of-eight coil (external loop diameter of 9 cm), sham coil and double cone coil. The stimulator generates a monophasic magnetic field of up to 1.7 Tesla. The coil is maintained in the desired position by a custom apparatus and can be moved or placed optimally, while keeping its position stable throughout the experiment. The stimulation system is connected to a neuro-navigation device (Navigation Brain System 2.3, Nexstim, Helsinki, Finland) and uses an individual\u0026rsquo;s anatomical T1 MRI to precisely guide the stimulation. The system computes an estimate of the electrical field induced in the cortex by the TMS pulse in real time and displays it on the subject\u0026rsquo;s MRI. The characteristics of the electric field induced by each TMS pulse (localization, orientation and intensity) are recorded by the neuro-navigation device. In addition, we have a TMS-compatible EEG system comprising of BrainAMP Direct-Current amplifiers (BrainProducts, Gilching, Germany) and a 62-electrode cap (Fast \u0026amp; Easy Cap). Data is recorded using BrainVision Recorder software EEG online processing. It is also possible to trigger TMS (or any other stimulus) depending on some properties of the EEG signal using this Brain Vision Recview software.\nFor more information about the TMS lab, please contact Mireille Bonnard.\nEpilepsy Patient Clinic | sEEG # The \u0026ldquo;Service d\u0026rsquo;Epileptologie et Rythmologie Cérébrale, Hôpital de La Timone, Assistance Publique - Hôpitaux de Marseille\u0026rdquo; is dedicated to the diagnosis and treatment of different types of epilepsy, the diagnosis of loss of consciousness episodes and sleep disorders. The department is also involved in the different EEG and evoked potentials approaches for the diagnosis of brain diseases. It hosts the MEG center that provides both research and clinical investigations for patients with drug resistant epilepsy. The department is part of the \u0026ldquo;Centre d\u0026rsquo;Investigation Neurologique Adulte et Pédiatrique pour les Soins en Epileptologie\u0026rdquo; (CINAPSE) dedicated to the management of adult and pediatric cases of epilepsy in Marseille, which includes three centres: Hôpital Henri Gastaut, the Clinical Neurosciences Centre and the AP-HM Neuropédiatrie Service.\nFabrice Bartolomei, MD, PhD is a neurologist specialized in epilepsy and Professor at the Aix-Marseille University leading this department. Prof. Bartolomei is also the medical director coordinating the clinical network CINAPSE. He is particularly involved in the presurgical evaluation of patients with drug resistant epilepsy and is a world leader in the analysis of Stereo-EEG recordings. He has published numerous studies in the field of, particularly on the concept of \u0026ldquo;Epileptogenic Networks\u0026rdquo;. He has promoted the use of EEG/SEEG analysis and is the co-inventor of the \u0026ldquo;Epileptogenicity Index\u0026rdquo;, a method for assessing epileptogenicity of brain regions.\nHe is the coordinator of the \u0026ldquo;Improving EPilepsy surgery management and progNOsis using Virtual brain technology\u0026rdquo; (EPINOV) project funded in the context of the RHU3 call. Contact Dr Fabrice Bartolomei.\n","externalUrl":null,"permalink":"/platforms-clinics/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Platforms \u0026 Clinics — INS","type":"page"},{"content":"","externalUrl":null,"permalink":"/publications/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Publications","type":"page"},{"content":"DynaMap\nI graduated as a biologist, I received one research PhD in Neuroscience and one theoretical PhD in affective science both at the university of Geneva, in the laboratory of Pr. Vuilleumier. My research interests include emotion, awareness, cognitive control, attention, neuronal plasticity and Brain Computer Interface (such as Neurofeedback), in both healthy subjects and clinical neuroscience, with a special interest on Epilepsy. In my young career, I used fMRI, EEG, iEEG and Neurofeedback in my research. Here is research gate page and my google scholar page.\n","externalUrl":null,"permalink":"/members/raphael-guex/","section":"Membres","summary":"DynaMap","title":"Raphael Guex","type":"members"},{"content":"TNG\n","externalUrl":null,"permalink":"/members/roland-rizouliere/","section":"Membres","summary":"TNG","title":"Roland Rizouliere","type":"members"},{"content":"Biographie à compléter.\n","externalUrl":null,"permalink":"/members/romain-carron/","section":"Membres","summary":"Membre de l’Institut de Neurosciences des Systèmes.","title":"Romain Carron","type":"members"},{"content":"TNG\n","externalUrl":null,"permalink":"/members/romain-guilhaumou/","section":"Membres","summary":"TNG","title":"Romain Guilhaumou","type":"members"},{"content":"DCP\n","externalUrl":null,"permalink":"/members/sabrina-rodrigues/","section":"Membres","summary":"DCP","title":"Sabrina Rodrigues","type":"members"},{"content":"Dynamap\nGraduated from Phelma (Grenoble-INP) engineering school in 2014, I joined the DynaMap team to work on the Vibrations project. My work is to develop some signal processing tools for researchers or clinicians to ease their analysis.\n","externalUrl":null,"permalink":"/members/samuel-medina/","section":"Membres","summary":"Dynamap","title":"Samuel Medina","type":"members"},{"content":"Doctor in neuroscience with experience on intracranial human recordings and transcranial electrical stimulation. Currently working as a post-doc in PhysioNet, with a project on circadian and multidien rhythms in epileptic activity of rats (single units and lfp). Open science advocate and part-time photographer.\n","externalUrl":null,"permalink":"/members/sara-simula/","section":"Membres","summary":"Doctor in neuroscience with experience on intracranial human recordings and transcranial electrical stimulation. Currently working as a post-doc in PhysioNet, with a project on circadian and multidien rhythms in epileptic activity of rats (single units and lfp). Open science advocate and part-time photographer.","title":"Sara Simula","type":"members"},{"content":"Site search interface.\n","externalUrl":null,"permalink":"/search/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Search","type":"page"},{"content":"NeuroStim\n","externalUrl":null,"permalink":"/members/sofia-avalos-alais/","section":"Membres","summary":"NeuroStim","title":"Sofia Avalos-Alais","type":"members"},{"content":"One of the defining features of INS is our dedication to conducting true translational research. It is our intention to traverse the \u0026lsquo;bench to bedside\u0026rsquo; model, from start to finish. In order to achieve this, we often encounter instances where we need to actually develop the necessary tools to answer the questions at hand. Our capacity to build the technological steppingstones to ensure our foundational research translates to actual applications, primes us to lead scientific discovery to innovative and impactful new heights.\nTHE VIRTUAL BRAIN # The Virtual Brain (TVB) is an open-source neuroinformatics platform, which combines a large-scale brain network model and neuroimaging modality (s/EEG/MEG \u0026amp; fMRI) simulator, optimized for realistic brain connectivity \u0026amp; geometry and neural mass models, with a framework for constructing, visualizing and analyzing brain network models in a collaborative, project oriented user interface. Although TVB is lightweight enough to download and run on your local machine, TVB is also backed by dedicated high-performance computing hardware, complemented by clustered nodes for virtual machines running public-facing web services, located in the medical faculty of the La Timone campus. Our HPC enables users to exponentially grow their simulations both in quantity and processing speed.\nANYWAVE # AnyWave is a multi-platform software for visualizing and processing EEG/SEEG/MEG/XMG data from any EEG or MEG acquisition systems. AnyWave is modular and can load additional plug-ins to enhance its features and capabilities. The development of AnyWave is supported by INSERM and Aix-Marseille University. The main developer is Bruno Colombet, member of the DynaMap research group at INS.\nMULAN # MULtiple connectivity ANalysis (MULAN) is a MATLAB toolbox to help researchers evaluate connectivity analysis methods in a systematic way. Prior to applying specific methods to a given dataset, MULAN can be used to generate relevant simulated signals, identify valid parameter ranges for the methods, and evaluate their performance and robustness against underlying features. Lastly, new methods can easily be added and tested. Available from Github.\nContact Huifang Wang for further information.\nEPITOOLS # Epitools is a suite of software packages developed by the DynaMap research group to enable researchers to look at neuroimaging data in a new way.\nVEP ATLAS # VEP atlas is an anatomic and functional human brain atlas dedicated to epilepsy patients, developed in INS.\nThe GitHub code is here.\n","externalUrl":null,"permalink":"/software/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Software — INS","type":"page"},{"content":"DCP\n","externalUrl":null,"permalink":"/members/sophie-chen/","section":"Membres","summary":"DCP","title":"Sophie Chen","type":"members"},{"content":"After graduating as MSc in Electrical Engineering at Sts. Cyril and Methodius University (Macedonia) in 2014, I obtained a PhD in Physics as part of the Nonlinear and Biomedical Physics group at Lancaster University (UK), after which I joined INS.\nMy research interests are at the intersection of nonlinear dynamics and computational neuroscience. I am interested in concepts from synchronization and population dynamics in application to brain-network modeling, with particular interest on the impact of time-delays. Using the brain-network modelling paradigm, I study the stability of network dynamics in surgical resection during epilepsy, and the impact of network damage in context of stroke. Additionally I’m involved in time-series analysis with time-frequency, information theory and statistical methods applied to electrophysiological and functional imaging data in relation to the whole-brain dynamics.\n","externalUrl":null,"permalink":"/members/spase-petkoski/","section":"Membres","summary":"After graduating as MSc in Electrical Engineering at Sts. Cyril and Methodius University (Macedonia) in 2014, I obtained a PhD in Physics as part of the Nonlinear and Biomedical Physics group at Lancaster University (UK), after which I joined INS.","title":"Spase Petkoski","type":"members"},{"content":"Research Gate | Scholar | ORCID\nI am a neurologist specialized in epileptology and neurophysiology. I have a clinical and research focus on drug-resistant epilepsies and especially epilepsy surgery. My main topic is the study of epileptic network using intracranial EEG (SEEG).\n","externalUrl":null,"permalink":"/members/stanislas-lagarde/","section":"Membres","summary":"Research Gate | Scholar | ORCID","title":"Stanislas Lagarde","type":"members"},{"content":"DCP\n","externalUrl":null,"permalink":"/members/stephane-roman/","section":"Membres","summary":"DCP","title":"Stéphane Roman","type":"members"},{"content":"TNG\n","externalUrl":null,"permalink":"/members/sylvie-bonin-guillaume/","section":"Membres","summary":"TNG","title":"Sylvie Bonin-Guillaume","type":"members"},{"content":"PhysioNet\n","externalUrl":null,"permalink":"/members/sylvie-thirion/","section":"Membres","summary":"PhysioNet","title":"Sylvie Thirion","type":"members"},{"content":"DCAP\nMail: tessa.CANCIO-PASTOR@univ-amu.fr\n","externalUrl":null,"permalink":"/members/tessa-cancio-pastor/","section":"Membres","summary":"DCAP","title":"Tessa Cancio-Pastor","type":"members"},{"content":"","externalUrl":null,"permalink":"/topics/","section":"Topics","summary":"","title":"Topics","type":"topics"},{"content":" Respect, Equality, Diversity # The \u0026ldquo;Cognitive Biases\u0026rdquo; group at INS aims to expose the different biases associated with gender, disability, ethnicity, and sexual orientation for example. We share information and animate discussions to understand better these - often implicit - mechanisms that distort thinking.\nAims: # Research and implement solutions to promote equality and inclusiveness, and to combat discrimination and harassment within the laboratory. Raise awareness of the importance of these issues and the existence of cognitive biases, particularly implicit ones Provide information on current events (local \u0026amp; national) and AMU training courses on these issues Listening to and guiding potential victims and/or witnesses of discrimination The \u0026ldquo;Cognitive Biases\u0026rdquo; group is currently composed of Aurélie Bidet-Caulet, Sophie Chen, Damien Depannemaecker, and Marmaduke Woodman. Our group is obviously open and you can contact us if you wish to join it.\nThe \u0026ldquo;service respect et égalité\u0026rdquo; of AMU offers to support victims of harassment, and discrimination (in all forms) but also for situations of sexist and sexual violence in a confidential and independent way. More information on their website https://www.univ-amu.fr/fr/public/respect-egalite.\nAt Inserm, a group is in charge of collecting and processing reports of violence, discrimination, harassment and sexist behavior in the workplace. It includes measures to support, protect and guide victims.\n","externalUrl":null,"permalink":"/values/","section":"Institut de Neurosciences des Systèmes","summary":"","title":"Values — INS","type":"page"},{"content":"My PhD is focused on language and speech therapy under the supervision of Pr Agnès TREBUCHON (INS) and F.-Xavier ALARIO (LPC). We explore the effect of prehabilitation (rehabilitation before neurosurgery) in the context of drug-resistant epilepsy. We are developing online rehabilitation tools in collaboration with Christelle ZIELINSKI (The ILCB Center of Experimental Resources). We are trying to understand if and how prehabilitation could improve cognitive resilience of the patients to surgical risk.\nemail : veronique.sabadell@ap-hm.fr\nDCP\n","externalUrl":null,"permalink":"/members/veronique-sabadell/","section":"Membres","summary":"My PhD is focused on language and speech therapy under the supervision of Pr Agnès TREBUCHON (INS) and F.-Xavier ALARIO (LPC). We explore the effect of prehabilitation (rehabilitation before neurosurgery) in the context of drug-resistant epilepsy. We are developing online rehabilitation tools in collaboration with Christelle ZIELINSKI (The ILCB Center of Experimental Resources). We are trying to understand if and how prehabilitation could improve cognitive resilience of the patients to surgical risk.","title":"Véronique Sabadell","type":"members"},{"content":"Dynamap\nDCP\nAs a former engineer, I’m specialized on signal analysis and brain connectivity. During my PhD I studied the synchronization between different theta and gamma rhythms in the hippocampus of the rat at the Neuroscience Institute of Alicante, Spain. Then, I moved to Marseille to analyze simultaneous recordings at different scales (EEG, MEG, SEEG…) in patients with epilepsy. I worked with Dr. Benjamin Morillon on the role of theta and gamma oscillations in the auditory cortex during speech perception.\nNow, my work is focused on the development of the OPM-MEG technology for epilepsy and functional mapping.\n","externalUrl":null,"permalink":"/members/victor-lopez-madrona/","section":"Membres","summary":"Dynamap","title":"Victor Lopez-Madrona","type":"members"},{"content":"TNG - Team Lead\nDirector of INS\nPhone: +33 4 91 32 42 51\nSince the late 90s he has made contributions to the understanding of how network structure constrains the emergence of functional dynamics using methods from nonlinear dynamic system theory and computational neuroscience. Dr. Jirsa has been awarded several international and national awards for his research including the Early Career Distinguished Scholar Award in 2004 and the Francois Erbsmann Prize in 2001. He serves on various Editorial Boards and has published more than 80 scientific articles and book chapters, as well as co-edited several books including the Handbook of Brain Connectivity.\n","externalUrl":null,"permalink":"/members/viktor-jirsa/","section":"Membres","summary":"TNG - Team Lead","title":"Viktor Jirsa","type":"members"},{"content":"TNG\n","externalUrl":null,"permalink":"/members/xavier-zendjidjian/","section":"Membres","summary":"TNG","title":"Xavier Zendjidjian","type":"members"},{"content":"Dynamap\nDiplômée d’un Master 2 en traitement du signal et des images biomédicales à Aix-Marseille Université, je travaille en tant qu’ingénieure en traitement de données EEG/MEG. Mon activité se concentre principalement sur la gestion et la structuration des données au format BIDS (Brain Imaging Data Structure) afin de faciliter leur organisation, leur partage, leur reproductibilité et leur analyse. Je contribue également au prétraitement et à l’analyse des données neurophysiologiques, notamment à l’aide d’approches de machine learning.\n","externalUrl":null,"permalink":"/members/zakia-chidhouri/","section":"Membres","summary":"Dynamap","title":"Zakia Chidhouri","type":"members"}]