DynaMap

Cartographie dynamique du cerveau et épilepsies focales

Épilepsie MEG EEG / SEEG Cartographie cérébrale

Responsable : Christian Bénar — DR Inserm

(Dynamical Brain Mapping and Pathophysiology of Focal Human Epilepsies)

The main research themes of the DynaMaP team are i) the methodology of brain mapping for epilepsy and cognition (based on EEG, magnetoencephalography and intracerebral EEG) ii) the pathophysiology of human epilepsy. A key feature of the team is to be composed of people with diverse backgrounds (engineers, clinicians, neuroscientists) and to be located within the Timone hospital, which ensures tight collaboration between research and clinics. In the past years, we notably obtained results on the characterization of epileptic networks and on the simultaneous recording of MEG an intracerebral EEG.

We are part of large-scale projects (RHU Epinov, ERC Galvani). Moreover, the Dynamap team runs the magnetoencephalography platform, which has the IBISA and “AMU platform” labels, is member of France Life Imaging network, and of several AMU Institutes (NeuroMarseille, Laënnec, Marseille Imaging).

A particular effort is made towards translation of our work to clinicians and researchers through the multi-platform Anywave software and its associated plugins (epileptogenicity Index, Delphos, Gardel…), which architecture specifically aims at allowing fast implementation of algorithms to the end users.

We obtained recently an A*midex industrial chair, “NewMeg Marseille”, in collaboration with the Meg4Health company.

DYNAMAP RESEARCH
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Simultaneous recordings of MEG, EEG and SEEG
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Most previous work on the comparison of MEG, EEG and intracerebral EEG was performed on separate recordings. However, this is far from being optimal. Indeed, only simultaneous recordings of surface and depth activity permit to investigate the exact same activity, independently of spontaneous fluctuations that can occur from a session to another (depending on subject state, medication etc). Moreover, simultaneous recordings allow using interevent fluctuations as a source of information on the link between signals, as was done on simultaneous EEG-fMRI.

We have shown for the first time the feasibility of trimodal simultaneous recordings: EEG, MEG and SEEG (Dubarry et al., 2014). Technical developments have been proposed in (Badier et al., 2017) and an application to presurgical mapping in (Gavaret et al., 2016). Recently, thanks to the simultaneous intracerebral recordings, we have shown that it is possible to capture the activity of deep structures on MEG (Pizzo et al 2019, López-Madrona et al. 2022).

Badier JM, Dubarry AS, Gavaret M, Chen S, Trebuchon AS, Marquis P, Regis J, Bartolomei F, Benar CG & Carron R (2017) “Technical solutions for simultaneous MEG and SEEG recordings: towards routine clinical use.” Physiol Meas 38(10): N118-N127.

Gavaret M, Dubarry AS, Carron R, Bartolomei F, Benar CG & Trébuchon A (2016) “Simultaneous SEEG-MEG-EEG recordings overcome the SEEG limited spatial sampling.” Epilepsy Res 128: 67:72.

Pizzo F, Roehri N, Medina Villalon S, Trébuchon A, Chen S, Lagarde S, Carron R, Gavaret M, Giusiano B, McGonigal A, Bartolomei F, Badier JM, Bénar CG. Deep brain activities can be detected with magnetoencephalography. Nat Commun. 2019 Feb 27;10(1):971.